Results 281 to 290 of about 7,313,278 (356)
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li+10 more
wiley +1 more source
Tumor Microenvironment: A Complex Landscape of Cancer Development and Drug Resistance. [PDF]
Fatima S.
europepmc +1 more source
The Regulation of Trace Metal Elements in Cancer Ferroptosis
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang+5 more
wiley +1 more source
Lysosomes and LAMPs as Autophagy Drivers of Drug Resistance in Colorectal Cancer. [PDF]
Ivanova T+3 more
europepmc +1 more source
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran+5 more
wiley +1 more source
Editorial: Opportunistic pathogens: pathogenesis and multi-drug resistance mechanisms. [PDF]
Chen S, Liao L, Wang M.
europepmc +1 more source
Incorporating nanosized silver into titanium for antimicrobial materials exploits the metastable miscibility gap between silver and titanium. Silver nanoparticles are synthesized via pulsed laser ablation in liquid. Silver addition refines the microstructure, increases hardness by 30%, and reduces Staphylococcus capitis microbial adhesion by 70%, with ...
Hamed Shokri+4 more
wiley +1 more source
Correction to 'Pathogen-encoded Rum DNA polymerase drives rapid bacterial drug resistance'. [PDF]
europepmc +1 more source
Bibliometric analysis of hotspots in <i>Staphylococcus aureus</i> drug resistance research. [PDF]
Shi J.
europepmc +1 more source