Results 21 to 30 of about 7,313,278 (356)
Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer
Frontiers in Pharmacology, 2021 Although chemotherapy, targeted therapy and endocrine therapy decrease rate of disease recurrence in most breast cancer patients, many patients exhibit acquired resistance.
Chao Dong +4 more
semanticscholar +1 more source
Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance
Frontiers in Immunology, 2021 The tumor microenvironment (TME) is a complex and ever-changing “rogue organ” composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells and extracellular matrix (ECM).
Khalil Khalaf +5 more
semanticscholar +1 more source
PLoS Medicine, 2017 Resistance to first-line treatments for Plasmodium falciparum malaria and the insecticides used for Anopheles vector control are threatening malaria elimination efforts. Suboptimal responses to drugs and insecticides are both spreading geographically and
malERA Refresh Consultative Panel on Insecticide and Drug Resistance
doaj +1 more source
Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma
Pharmaceuticals, 2021 Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest tumors worldwide. The diagnosis is often possible only in the latter stages of the disease, with patients already presenting an advanced or metastatic tumor. It is also one of the
Rita Rebelo +4 more
doaj +1 more source
EMT‐associated microRNAs and their roles in cancer stemness and drug resistance
Cancer Communications, 2021 Epithelial‐to‐mesenchymal transition (EMT) is implicated in a wide array of malignant behaviors of cancers, including proliferation, invasion, and metastasis.
G. Pan +4 more
semanticscholar +1 more source
Drug Resistance in Leishmaniasis [PDF]
Journal of Global Infectious Diseases, 2010 The treatment options of leishmaniasis are limited and far from satisfactory. For more than 60 years, treatment of leishmaniasis has centered around pentavalent antimonials (Sb(v)). Widespread misuse has led to the emergence of Sb(v) resistance in the hyperendemic areas of North Bihar. Other antileishmanials could also face the same fate, especially in
Shyam Sundar, Jaya Chakravarty
openaire +4 more sources
eLife, 2020 This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo assembled genomes. Integrative analysis yielded four key results.
Samuel J Modlin +9 more
doaj +1 more source
Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance
Frontiers in Molecular Biosciences, 2020 Nanotechnology has been extensively studied and exploited for cancer treatment as nanoparticles can play a significant role as a drug delivery system.
Yihan Yao +9 more
semanticscholar +1 more source
Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance
Cancers, 2021 Simple Summary Despite recent therapeutic advances against cancer, many patients do not respond well or respond poorly, to treatment and develop resistance to more than one anti-cancer drug, a term called multi-drug resistance (MDR).
C. Neophytou +3 more
semanticscholar +1 more source
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer
Cells, 2021 Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia contributes to drug resistance in cancer through various molecular mechanisms.
Macus Hao-Ran Bao, C. C. Wong
semanticscholar +1 more source