Results 21 to 30 of about 2,275,826 (357)

Nanoparticle-Based Delivery Strategies for Combating Drug Resistance in Cancer Therapeutics [PDF]

Cancers (Basel)
Park S, Lu G, Zheng Y, Davison E, Li Y.
europepmc   +3 more sources

The Value of Neutrophil Gelatinase-Associated Lipocalin Receptor as a Novel Partner of CD38 in Chronic Lymphocytic Leukemia: From an Adverse Prognostic Factor to a Potential Pharmacological Target?

Biomedicines, 2023
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes that escape death, and correlates with the expression of negative prognostic markers such as the CD38 antigen.
Brigitte Bauvois, Elise Chapiro, Claire Quiney, Karim Maloum, Santos A. Susin, Florence Nguyen-Khac   +5 more
doaj   +1 more source

Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa [PDF]

, 2014
Substantial amounts of data have been generated from patient management and academic exercises designed to better understand the human immunodeficiency virus (HIV) epidemic and design interventions to control it.
Bester, Armand, Chetty, Terusha, Danaviah, Siva, De Oliveira, Tulio, Goedhals, Dominique, Iwuji, Collins, Lessells, Richard, Manasa, Justen, McGrath, Nuala, Moodley, Pravi, Naidu, Kevindra, Rossouw, Theresa, Seebregts, Christopher J, Singh, Lavanya, Skingsley, Andrew, Stott, Katharine, Van Vuuren, Cloete, Van Zyl, Gert   +17 more
core   +3 more sources

Rv1453 is associated with clofazimine resistance in Mycobacterium tuberculosis

Microbiology Spectrum, 2023
Clofazimine (CFZ) has been repurposed for treating tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB). However, the mechanisms of resistance to clofazimine are poorly understood.
Lei Zhang, Ye Zhang, Yuanyuan Li, Fengmin Huo, Xi Chen, Hui Zhu, Shaochen Guo, Lei Fu, Bin Wang, Yu Lu   +9 more
doaj   +1 more source

Multiplex CRISPRi System Enables the Study of Stage-Specific Biofilm Genetic Requirements in Enterococcus faecalis

mBio, 2020
Enterococcus faecalis is an opportunistic pathogen, which can cause multidrug-resistant life-threatening infections. Gaining a complete understanding of enterococcal pathogenesis is a crucial step in identifying a strategy to effectively treat ...
Irina Afonina, June Ong, Jerome Chua, Timothy Lu, Kimberly A. Kline   +4 more
doaj   +1 more source

Drug resistance and combating drug resistance in cancer

Cancer Drug Resistance, 2019
Cancer is the second leading cause of death in the US. Current major treatments for cancer management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy, endocrine therapy and immunotherapy. Despite the endeavors and achievements made in treating cancers during the past decades, resistance to classical chemotherapeutic agents ...
Wang, Xuan, Zhang, Haiyun, Chen, Xiaozhuo   +2 more
openaire   +3 more sources

Drug resistant tuberculosis [PDF]

BMJ, 1995
EDITOR,—Concern is growing over the spread of drug resistant Mycobacterium tuberculosis. New evidence suggests that this spread may be increasing in certain sections of the British population. The recent advances in molecular techniques have equipped us with the means to make substantial inroads into the possible impact of drug resistant tuberculosis.1
openaire   +4 more sources

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]

, 2017
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E, Bole, Dhruv, Dhruv, Harshil D, Eaton, John K, Galeas, Jacqueline, Hangauer, Matthew J, Matov, Alexandre, McCormick, Frank, McManus, Michael T, Ryan, Matthew J, Schreiber, Stuart L, Viswanathan, Vasanthi S   +11 more
core   +1 more source

The HIV-1 subtype C epidemic in South America is linked to the United Kingdom.

PLoS ONE, 2010
BackgroundThe global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of South
Tulio de Oliveira, Deenan Pillay, Robert J Gifford, UK Collaborative Group on HIV Drug Resistance   +3 more
doaj   +1 more source

Development of a Real-Time Recombinase-Aided Amplification Method to Rapidly Detect Methicillin-Resistant Staphylococcus aureus

Microorganisms, 2022
Methicillin-resistant staphylococcus aureus (MRSA) is a major pathogen responsible for human hospital and community-onset diseases and severe invasive livestock infections. Rapid detection of MRSA is essential to control the spread of MRSA.
Xiaoyan Ding, Hejia Wang, Mingquan Cui, Min Cheng, Qi Zhao, Yuhui Bai, Chunping Zhang, Cunshuai Zhang, Shixin Xu, Ting Li   +9 more
doaj   +1 more source