Results 11 to 20 of about 1,255,487 (165)
Drug resistant tuberculosis [PDF]
BMJ, 1995 EDITOR,—Concern is growing over the spread of drug resistant Mycobacterium tuberculosis. New evidence suggests that this spread may be increasing in certain sections of the British population. The recent advances in molecular techniques have equipped us with the means to make substantial inroads into the possible impact of drug resistant tuberculosis.1
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Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma
Pharmaceuticals, 2021 Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest tumors worldwide. The diagnosis is often possible only in the latter stages of the disease, with patients already presenting an advanced or metastatic tumor. It is also one of the
Rita Rebelo +4 more
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Survival outcomes of autologous breast reconstruction after mastectomy: A matched case-control study
Frontiers in Oncology, 2023 BackgroundDue to the lack of strong evidence-based medical evidence, the relationship between autologous breast reconstruction (ABR) after mastectomy and long-term prognosis is unclear.
Shang Wu +11 more
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mBio, 2020 Enterococcus faecalis is an opportunistic pathogen, which can cause multidrug-resistant life-threatening infections. Gaining a complete understanding of enterococcal pathogenesis is a crucial step in identifying a strategy to effectively treat ...
Irina Afonina +4 more
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Biomedicines, 2023 Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes that escape death, and correlates with the expression of negative prognostic markers such as the CD38 antigen.
Brigitte Bauvois +5 more
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Rv1453 is associated with clofazimine resistance in Mycobacterium tuberculosis
Microbiology Spectrum, 2023 Clofazimine (CFZ) has been repurposed for treating tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB). However, the mechanisms of resistance to clofazimine are poorly understood.
Lei Zhang +9 more
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Resisting Bacterial Drug Resistance [PDF]
Chemistry & Biology, 2003 In this issue of Chemistry & Biology, Wright and colleagues report an elegant method for inhibiting enzymes critical for rendering bacteria drug resistant. By using cationic peptides as inhibitors, the authors have exploited two antibacterial mechanisms, making it doubly difficult for microbial retaliation.
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BMJ, 2007 HIV has an impressive ability to replicate, mutate, and diversify, so developing drugs or vaccines that can fully contain the virus is a challenge. The only consistently successful way to prevent replication of HIV is to administer a potent combination regimen that contains at least two and preferably three antiretroviral drugs.
Hiroyu, Hatano, Steven G, Deeks
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Microorganisms, 2022 Methicillin-resistant staphylococcus aureus (MRSA) is a major pathogen responsible for human hospital and community-onset diseases and severe invasive livestock infections. Rapid detection of MRSA is essential to control the spread of MRSA.
Xiaoyan Ding +9 more
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The HIV-1 subtype C epidemic in South America is linked to the United Kingdom.
PLoS ONE, 2010 BackgroundThe global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of South
Tulio de Oliveira +3 more
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