Results 41 to 50 of about 1,025,188 (216)

Quantitative proteomic view associated with resistance to clinically important antibiotics in Gram-positive bacteria: A systematic review

open access: yesFrontiers in Microbiology, 2015
The increase of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) poses a worldwide and serious health threat.
Chang-Ro eLee   +4 more
doaj   +1 more source

Drugs Resistance Analysis from Scarce Health Records via Multi-task Graph Representation [PDF]

open access: yesarXiv, 2023
Clinicians prescribe antibiotics by looking at the patient's health record with an experienced eye. However, the therapy might be rendered futile if the patient has drug resistance. Determining drug resistance requires time-consuming laboratory-level testing while applying clinicians' heuristics in an automated way is difficult due to the categorical ...
arxiv  

Circulating Epstein-Barr virus DNA and cell-free DNA in pediatric lymphomas

open access: yesThe Turkish Journal of Pediatrics, 2020
Background and Objectives. Quantification of serum Epstein-Barr virus (EBV) DNA and/or cell-free total DNA (cf-DNA) may become valuable sources for prognosis evaluation and monitoring treatment response in lymphomas.
Bilgehan Yalçın   +4 more
doaj   +1 more source

Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway

open access: yesBiomedicines, 2021
Besides their antiviral and immunomodulatory functions, type I (α/β) and II (γ) interferons (IFNs) exhibit either beneficial or detrimental effects on tumor progression.
Brigitte Bauvois   +5 more
doaj   +1 more source

The Impact of Competition Between Cancer Cells and Healthy Cells on Optimal Drug Delivery [PDF]

open access: yes, 2018
Cell competition is recognized to be instrumental to the dynamics and structure of the tumor-host interface in invasive cancers. In mild competition scenarios, the healthy tissue and cancer cells can coexist. When the competition is aggressive, competitive cells, the so called super-competitors, expand by killing other cells.
arxiv   +1 more source

Glycosphingolipids and drug resistance

open access: yesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Drug resistance, an all too frequent characteristic of cancer, represents a serious barrier to successful treatment. Although many resistance mechanisms have been described, those that involve membrane-resident proteins belonging to the ABC (ATP binding cassette) transporter superfamily are of particular interest.
Myles C. Cabot   +1 more
openaire   +3 more sources

Phylodynamic analysis reveals CRF01_AE dissemination between Japan and neighboring Asian countries and the role of intravenous drug use in transmission. [PDF]

open access: yesPLoS ONE, 2014
BACKGROUND: One major circulating HIV-1 subtype in Southeast Asian countries is CRF01_AE, but little is known about its epidemiology in Japan. We conducted a molecular phylodynamic study of patients newly diagnosed with CRF01_AE from 2003 to 2010 ...
Teiichiro Shiino   +5 more
doaj   +1 more source

Phenotypic Characterization and Heterogeneity among Modern Clinical Isolates of Acinetobacter baumannii

open access: yesMicrobiology Spectrum, 2023
Acinetobacter baumannii is an opportunistic pathogenic bacterium prioritized by WHO and CDC because of its increasing antibiotic resistance. Heterogeneity among strains represents the hallmark of A. baumannii bacteria.
Adam Valcek   +10 more
doaj   +1 more source

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples

open access: yesAdvances in Virology, 2011
The MLV-related retrovirus, XMRV, was recently identified and reported to be associated with both prostate cancer and chronic fatigue syndrome. At the National Cancer Institute-Frederick, MD (NCI-Frederick), we developed highly sensitive methods to ...
M. F. Kearney   +17 more
doaj   +1 more source

ALNSynergy: a graph convolutional network with multi-representation alignment for drug synergy prediction [PDF]

open access: yesarXiv, 2023
Drug combination refers to the use of two or more drugs to treat a specific disease at the same time. It is currently the mainstream way to treat complex diseases. Compared with single drugs, drug combinations have better efficacy and can better inhibit toxicity and drug resistance.
arxiv  

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