Results 41 to 50 of about 8,375,389 (400)

The Value of Neutrophil Gelatinase-Associated Lipocalin Receptor as a Novel Partner of CD38 in Chronic Lymphocytic Leukemia: From an Adverse Prognostic Factor to a Potential Pharmacological Target?

Biomedicines, 2023
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes that escape death, and correlates with the expression of negative prognostic markers such as the CD38 antigen.
Brigitte Bauvois, Elise Chapiro, Claire Quiney, Karim Maloum, Santos A. Susin, Florence Nguyen-Khac   +5 more
doaj   +1 more source

Rv1453 is associated with clofazimine resistance in Mycobacterium tuberculosis

Microbiology Spectrum, 2023
Clofazimine (CFZ) has been repurposed for treating tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB). However, the mechanisms of resistance to clofazimine are poorly understood.
Lei Zhang, Ye Zhang, Yuanyuan Li, Fengmin Huo, Xi Chen, Hui Zhu, Shaochen Guo, Lei Fu, Bin Wang, Yu Lu   +9 more
doaj   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
A Balmain, AJ Boivin, B Hendrich, BC Richardson, C Anacleto, C Grunau, CA Eads, E Bair, E Papouli, EE Cameron, F Lyko, G Egger, G Gifford, G Strathdee, G Strathdee, HG Chang, J Hall, J M Teodoridis, J Tra, JA Plumb, JF Costello, JG Herman, JM Teodoridis, JM Teodoridis, JP Issa, K Yamashita, L Zhang, LA Loeb, M Daskalakis, M Esteller, M Esteller, M Esteller, M Lachner, M Toyota, ME Valk-Lingbeek, MF Paz, MF Paz, MM Gottesman, MS Soengas, NP Bhattacharyya, PJ Johnson, PM Warnecke, R Agarwal, R Brown, R Brown, R M Glasspool, S Fulda, SH Wei, SH Wei, SL Gerson, SM Taylor, SW Lowe, T Taniguchi, T Ushijima, TH Huang, W Fischle, Y Pommier, Z Xiong   +57 more
core   +2 more sources

HATs On for Drug Resistance [PDF]

Cell Host & Microbe, 2011
Mutations in the human cytomegalovirus UL27 gene confer resistance to an inhibitor of the viral protein kinase UL97. Reitsma and colleagues (2011) demonstrate that UL27 destabilizes the Tip60 histone acetyltransferase, setting forth intriguing new mechanisms for antiviral drug resistance and for viral regulation of the cell cycle.
Jeremy P. Kamil, Donald M. Coen
openaire   +3 more sources

Noncoding RNAs in gastric cancer: implications for drug resistance

Molecular Cancer, 2020
Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths worldwide. Advanced gastric cancer patients can notably benefit from chemotherapy including adriamycin, platinum drugs, 5-fluorouracil, vincristine ...
Ling Wei, Jujie Sun, Nasha Zhang, Yan Zheng, Xing-wu Wang, L. Lv, Jiandong Liu, Yeyang Xu, Yue Shen, Ming Yang   +9 more
semanticscholar   +1 more source

Multiplex CRISPRi System Enables the Study of Stage-Specific Biofilm Genetic Requirements in Enterococcus faecalis

mBio, 2020
Enterococcus faecalis is an opportunistic pathogen, which can cause multidrug-resistant life-threatening infections. Gaining a complete understanding of enterococcal pathogenesis is a crucial step in identifying a strategy to effectively treat ...
Irina Afonina, June Ong, Jerome Chua, Timothy Lu, Kimberly A. Kline   +4 more
doaj   +1 more source

Drug resistance and Cancer stem cells

Cell Communication and Signaling, 2021
Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and more aggressive clones that contribute to poor prognosis.
Yuan Li, Zhen-ning Wang, J. Ajani, Shumei Song   +3 more
semanticscholar   +1 more source

Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa [PDF]

, 2014
Substantial amounts of data have been generated from patient management and academic exercises designed to better understand the human immunodeficiency virus (HIV) epidemic and design interventions to control it.
Bester, Armand, Chetty, Terusha, Danaviah, Siva, De Oliveira, Tulio, Goedhals, Dominique, Iwuji, Collins, Lessells, Richard, Manasa, Justen, McGrath, Nuala, Moodley, Pravi, Naidu, Kevindra, Rossouw, Theresa, Seebregts, Christopher J, Singh, Lavanya, Skingsley, Andrew, Stott, Katharine, Van Vuuren, Cloete, Van Zyl, Gert   +17 more
core   +3 more sources

Development of a Real-Time Recombinase-Aided Amplification Method to Rapidly Detect Methicillin-Resistant Staphylococcus aureus

Microorganisms, 2022
Methicillin-resistant staphylococcus aureus (MRSA) is a major pathogen responsible for human hospital and community-onset diseases and severe invasive livestock infections. Rapid detection of MRSA is essential to control the spread of MRSA.
Xiaoyan Ding, Hejia Wang, Mingquan Cui, Min Cheng, Qi Zhao, Yuhui Bai, Chunping Zhang, Cunshuai Zhang, Shixin Xu, Ting Li   +9 more
doaj   +1 more source

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]

, 2017
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E, Bole, Dhruv, Dhruv, Harshil D, Eaton, John K, Galeas, Jacqueline, Hangauer, Matthew J, Matov, Alexandre, McCormick, Frank, McManus, Michael T, Ryan, Matthew J, Schreiber, Stuart L, Viswanathan, Vasanthi S   +11 more
core   +1 more source