Results 41 to 50 of about 8,234,457 (404)

The Reporting of a Disproportionality Analysis for Drug Safety Signal Detection Using Individual Case Safety Reports in PharmacoVigilance (READUS-PV): Development and Statement

Drug Safety
Disproportionality analyses using reports of suspected adverse drug reactions are the most commonly used quantitative methods for detecting safety signals in pharmacovigilance. However, their methods and results are generally poorly reported in published
M. Fusaroli, Francesco Salvo, Bernard Bégaud, T. Alshammari, Andrew Bate, V. Battini, Andreas Brueckner, G. Candore, Carla Carnovale, Salvatore Crisafulli, P. Cutroneo, Charles Dolladille, M. Drici, J. Faillie, Adam Goldman, M. Hauben, M. T. Herdeiro, Olivia Mahaux, Katrin Manlik, François Montastruc, Yoshihiro Noguchi, G. N. Norén, Roberta Noseda, Igho J Onakpoya, Antoine Pariente, E. Poluzzi, Myriam Salem, D. Sartori, N. T. Trinh, Marco Tuccori, Florence van Hunsel, E. V. van Puijenbroek, Emanuel Raschi, C. Khouri   +33 more
semanticscholar   +1 more source

Association Between Data Sources and US Food and Drug Administration Drug Safety Communications.

JAMA Internal Medicine, 2019
Association Between Data Sources and US Food and Drug Administration Drug Safety Communications Drug safety communications (DSCs) are the primary tool for the US Food and Drug Administration (FDA) to communicate important new postmarketing safety ...
Noam Tau, T. Shochat, A. Gafter-Gvili, A. Tibau, E. Amir, D. Shepshelovich   +5 more
semanticscholar   +1 more source

Determination of Anthelmintic and Antiprotozoal Drug Residues in Fish Using Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2021
The objective of this study is to develop a comprehensive and simple method for the simultaneous determination of anthelmintic and antiprotozoal drug residues in fish. For sample preparation, we used the “quick, easy, cheap, effective, rugged, and safe” (
Eunjung Kim, Sihyun Park, Hyunjin Park, Jangduck Choi, Hae Jung Yoon, Jeong-Han Kim   +5 more
doaj   +1 more source

An exploration strategy improves the diversity of de novo ligands using deep reinforcement learning: a case for the adenosine A2A receptor

Journal of Cheminformatics, 2019
Over the last 5 years deep learning has progressed tremendously in both image recognition and natural language processing. Now it is increasingly applied to other data rich fields. In drug discovery, recurrent neural networks (RNNs) have been shown to be
Xuhan Liu, Kai Ye, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen   +4 more
doaj   +1 more source

Varenicline and Nicotine Replacement Use Associated With US Food and Drug Administration Drug Safety Communications

JAMA Network Open, 2019
Key Points Question Did use of varenicline change after early US Food and Drug Administration drug safety communications regarding neuropsychiatric adverse events?
Ravi J. Desai, M. Good, A. San-Juan-Rodriguez, Andrew Henriksen, F. Cunningham, I. Hernandez, C. Good   +6 more
semanticscholar   +1 more source

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

Clinical and Translational Science, 2021
Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two‐dimensional (2D) in vitro cell culture systems cannot accurately depict and simulate the rich
Hongbing Wang, Paul C. Brown, E. Chow, L. Ewart, S. Ferguson, S. Fitzpatrick, Benjamin S. Freedman, G. Guo, W. Hedrich, S. Heyward, J. Hickman, N. Isoherranen, Albert P. Li, Qi Liu, S. Mumenthaler, J. Polli, W. Proctor, A. Ribeiro, Jian-Ying Wang, R. Wange, Shiew-Mei Huang   +20 more
semanticscholar   +1 more source

Safety of antiobesity drugs [PDF]

Therapeutic Advances in Drug Safety, 2013
Obesity is a major health problem worldwide. Although diet and physical activity are crucial in the management of obesity, the long-term success rate is low. Therefore antiobesity drugs are of great interest, especially when lifestyle modification has failed.
Cheung, TT, SAMARANAYAKE, NR, Cheung, BMY   +2 more
openaire   +4 more sources

The Influence of Safety, Efficacy, and Medical Condition Severity on Natural v. Synthetic Drug Preference

, 2016
Research indicates that there is a preference for natural v. synthetic products, but the influence of this preference on drug choice in the medical domain is largely unknown.
Lappas, Courtney M., Meier, Brian P.
core   +1 more source

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

Scientific Reports, 2021
Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays for SLCs are based on the uptake of radiolabeled or fluorescent substrates.
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman   +4 more
doaj   +1 more source

Rewarding and Reinforcing Effects of 25H-NBOMe in Rodents

Brain Sciences, 2022
The drug 25H-NBOMe is a new psychoactive substance (NPS). The use of these substances is likely to pose a threat to public health because they elicit effects similar to those of known psychoactive substances with similar chemical structures.
Cheolmin Jo, Hyejin Joo, Dong-Hyun Youn, Jin Mook Kim, Young-Ki Hong, Na Young Lim, Kwan Soo Kim, Su-Jeong Park, Sun Ok Choi   +8 more
doaj   +1 more source