Results 21 to 30 of about 927,468 (265)

Reports of myocarditis and pericarditis following mRNA COVID-19 vaccination: a systematic review of spontaneously reported data from the UK, Europe and the USA and of the scientific literature

BMJ Open, 2022
Objectives To combine spontaneously reported data from multiple countries to estimate reporting rate, and better understand risk factors for myocarditis and pericarditis following COVID-19 messenger RNA (mRNA) vaccines.Design Systematic review of ...
Saad Shakir, Samantha Lane, Alison Yeomans   +2 more
doaj   +1 more source

3DDPDs: describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors

Journal of Cheminformatics, 2023
Proteochemometric (PCM) modelling is a powerful computational drug discovery tool used in bioactivity prediction of potential drug candidates relying on both chemical and protein information.
Marina Gorostiola González, Remco L. van den Broek, Thomas G. M. Braun, Magdalini Chatzopoulou, Willem Jespers, Adriaan P. IJzerman, Laura H. Heitman, Gerard J. P. van Westen   +7 more
doaj   +1 more source

Drug safety and the media [PDF]

British Journal of Clinical Pharmacology, 2005
This article reviews the problems that may arise as a result of media coverage of drug safety issues. In order to promote more balanced coverage and avoid unnecessary scares, professionals working in the area of drug safety should rethink their strategies for dealing with the media.
Patrick C, Waller, Stephen J W, Evans, Keith, Beard   +2 more
openaire   +2 more sources

SAFETY OF HERBAL DRUGS

Journal of Research in Pharmacy, 2023
The quality and efficacy of treatment in the healthcare industry have dramatically changed over the last century as a consequence of advancements in medical science, mass manufacturing of chemically synthesized pharmaceuticals, and technologies. However, due to the fact that natural treatments are more accessible but also less expensive than prescribed
openaire   +3 more sources

Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

Molecular Medicine, 2020
The Editors-in-Chief would like to alert readers that this article [1] is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Liverpool with respect to the quantitative mass ...
Daniel James Antoine, Dominic P. Williams, Anja Kipar, Hugh Laverty, B. Kevin Park   +4 more
doaj   +1 more source

DrugEx v3: scaffold-constrained drug design with graph transformer-based reinforcement learning

Journal of Cheminformatics, 2023
Rational drug design often starts from specific scaffolds to which side chains/substituents are added or modified due to the large drug-like chemical space available to search for novel drug-like molecules.
Xuhan Liu, Kai Ye, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen   +4 more
doaj   +1 more source

Determination of Anthelmintic and Antiprotozoal Drug Residues in Fish Using Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2021
The objective of this study is to develop a comprehensive and simple method for the simultaneous determination of anthelmintic and antiprotozoal drug residues in fish. For sample preparation, we used the “quick, easy, cheap, effective, rugged, and safe” (
Eunjung Kim, Sihyun Park, Hyunjin Park, Jangduck Choi, Hae Jung Yoon, Jeong-Han Kim   +5 more
doaj   +1 more source

Drug safety and regulation [PDF]

BMJ, 2005
New powers and resources are needed I n the past few months, medical journals have published numerous editorials and news items relating to drug safety and regulation.1–3 The withdrawal of rofecoxib (Vioxx) has been the single biggest issue,4 but the cardiovascular safety of other cyclo-oxygenase-2 (COX 2) inhibitors5 and possible suicidal tendencies
Waller, Patrick C, Evans, Stephen JW, Beard, Keith   +2 more
openaire   +3 more sources

Monitoring of veterinary drug residues in livestock products with antimicrobial resistance

Applied Biological Chemistry
Antimicrobial resistance (AMR) in animal-derived products remains a global concern, while reports on veterinary drug (VD) residues in such products are relatively rare.
Dahae Park, Yu Ra Kim, Ji Young Kim, Jang-Duck Choi, Guiim Moon, Dong Woo Shin   +5 more
doaj   +1 more source

An exploration strategy improves the diversity of de novo ligands using deep reinforcement learning: a case for the adenosine A2A receptor

Journal of Cheminformatics, 2019
Over the last 5 years deep learning has progressed tremendously in both image recognition and natural language processing. Now it is increasingly applied to other data rich fields. In drug discovery, recurrent neural networks (RNNs) have been shown to be
Xuhan Liu, Kai Ye, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen   +4 more
doaj   +1 more source