Results 41 to 50 of about 4,880,179 (312)

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Medication safety in children [PDF]

, 2015
Background: The issue of medication safety has received considerable attention in the last few years. Especially drug related problems (DRP) are a major safety issue.
Glanzmann, C, Glanzmann, Corina
core   +1 more source

Quantitative transcriptome and proteome maps of classical nonclinical species

Scientific Data
The distribution of expression of target genes can provide insights that advance understanding of target availability to aid therapeutic development purposes.
Elias Oziolor, Liang Xue, Dennis Pelletier, Darien Capunitan, Emi Kimoto, Joel D. Federspiel, Mark Sheehan, Seda Arat, Leah Newman, Gahyun Lee, Jessie Qian, Steven Kumpf, Thomas A. Lanz, Matthew Martin, Nagappan Mathialagan   +14 more
doaj   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source

Optimization of an LC–MS/MS analytical method for strychnine in livestock and fishery products

Applied Biological Chemistry
Strychnine, an alkaloid recognized for its antagonist effects on glycine and acetylcholine receptors, is highly toxic and banned in several countries. It is also set to restricted in Republic of Korea from 2024, creating a need for a quantitative test ...
Jin Ha Sim, Hyesu Lee, Ji Young Kim, So–Ra Park, Gui–Hyun Jang, Miok Eom   +5 more
doaj   +1 more source

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

Scientific Reports, 2021
Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays for SLCs are based on the uptake of radiolabeled or fluorescent substrates.
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman   +4 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system. [PDF]

, 2013
BACKGROUND: Drug-related adverse events remain an important cause of morbidity and mortality and impose huge burden on healthcare costs. Routinely collected electronic healthcare data give a good snapshot of how drugs are being used in 'real-world ...
van der Lei Johan, Sturkenboom, Miriam, EU-ADR consortium, Lars Pedersen (65617), Lorenza Scotti, Paul Avillach (173608), Furlong L, Sturkenboom, M., Helgee Ernst Ahlberg, Avillach, P, Gini R, Scott Boyer (173647), Avillach, P. (Paul), Pedersen, L. (Lars), Miriam Sturkenboom (408749), Mazzaglia, G, Mestres J, Mestres, Jordi, Bauer Mehren, A, Scotti, L, Picelli, G. (Gino), Ernst Ahlberg Helgee (173638), José Luis Oliveira (451346), Prieto-Merino D, Scotti, Lorenza, Coloma PM, Furlong, L.I. (Laura), Mazzaglia Giampiero, Gino Picelli (451351), Matthews, J, Herings, Ron, Giampiero Mazzaglia, Johan van der Lei, Matthews J, Matthews, J.N. (Justin Neil), Mestres i López, Jordi, Kors, J, Sanz, F, David Prieto-Merino (294768), van Mulligen, Erik, Prieto-Merino David, Molokhia M, Picelli G, Mazzaglia, Giampiero, Schuemie, Martijn J, Miriam Sturkenboom, Gini Rosa, Schuemie, Martijn J., Scotti L, van Mulligen, E, van Mulligen E, Prieto-Merino, David, Gianluca Trifirò, Sanz Ferran, Molokhia Mariam, Molokhia, Mariam, Gini, R, Martijn J. Schuemie (257191), Sturkenboom, M.C.J.M. (Miriam), Sanz F, Helgee, E.A. (Ernst Ahlberg), Helgee, EA, Martijn J Schuemie, Rosa Gini (451348), Molokhia, M. (Mariam), Schuemie MJ, Prieto-Merino, D. (David), Coloma Preciosa M., Molokhia, M, Johan van der Lei (451352), Justin Matthews, Mestres Jordi, Jordi Mestres (168498), Scotti Lorenza, Anna Bauer-Mehren, van der Lei, Johan, Schuemie, Martijn, Mazzaglia, G. (Giampiero), Paul Avillach, Erik van Mulligen, Oliveira JL, Sturkenboom, MCJM, Lorenza Scotti (365932), Jordi Mestres, Furlong Laura, Erik van Mulligen (451345), Helgee EA, Herings, R.M.C. (Ron), Trifirò, Gianluca, Laura Furlong, Boyer, S, Picelli, Gino, Coloma, Preciosa M., Avillach Paul, Schuemie Martijn J., Mazzaglia G, Lars Pedersen, Ferran Sanz (89706), Bauer-Mehren Anna, David Prieto-Merino, van der Lei, J, Boyer, Scott, Furlong, Laura I., 1971-, Preciosa M. Coloma (451342), Matthews Justin, Prieto Merino, D, Coloma, P.M. (Preciosa), Ferran Sanz, Sturkenboom M, Kors, Jan; id_orcid, Oliveira, J, Picelli, G, Mulligen, E.M. (Erik) van, Jan Kors, Kors Jan, Lei, J. (Johan) van der, Trifirò G, Herings, R, Prieto-Merino, D, Justin Matthews (451347), Kors, Jan, Lei, Johan, Trifirò, G. (Gianluca), ?, ?, Gini, R. (Rosa), Rosa Gini, van der Lei J, Coloma, Preciosa M, Bauer-Mehren, A. (Anna), Jan Kors (390655), Picelli Gino, Scott Boyer, Avillach, Paul, Coloma, Preciosa, Gini, Rosa, Mariam Molokhia, Martijn J. Schuemie, Oliveira, JL, Ernst Ahlberg Helgee, Helgee, Ernst Ahlberg, Gino Picelli, Sturkenboom Miriam, Oliveira, José Luis, Bauer-Mehren, A, Bauer-Mehren A, Ron Herings (451349), Pedersen, L, Boyer S, Mestres, J, Pedersen, Lars, van Mulligen Erik, Oliveira José Luis, Coloma, P, Mestres, J. (Jordi), Pedersen Lars, Boyer, S. (Scott), Matthews, Justin, Herings Ron, Kors J, Mariam Molokhia (54874), Schuemie, M.J. (Martijn), Sanz, Ferran, Kors, J.A. (Jan), Anna Bauer-Mehren (173597), Pedersen L, Boyer Scott, Trifirò, G, Preciosa M Coloma, Scotti, L. (Lorenza), José Luis Oliveira, Helgee, E, Ron Herings, Gianluca Trifirò (451343), Sanz, F. (Ferran), Furlong, L, Oliveira, J.L. (José Luis), Preciosa M. Coloma, Schuemie, M, Laura Furlong (451344), Avillach P, Furlong, Laura, Bauer-Mehren, Anna, Giampiero Mazzaglia (451350), Trifirò Gianluca, Herings R   +184 more
core   +2 more sources

Papyrus: a large-scale curated dataset aimed at bioactivity predictions

Journal of Cheminformatics, 2023
With the ongoing rapid growth of publicly available ligand–protein bioactivity data, there is a trove of valuable data that can be used to train a plethora of machine-learning algorithms.
O. J. M. Béquignon, B. J. Bongers, W. Jespers, A. P. IJzerman, B. van der Water, G. J. P. van Westen   +5 more
doaj   +1 more source

Rewarding and Reinforcing Effects of 25H-NBOMe in Rodents

Brain Sciences, 2022
The drug 25H-NBOMe is a new psychoactive substance (NPS). The use of these substances is likely to pose a threat to public health because they elicit effects similar to those of known psychoactive substances with similar chemical structures.
Cheolmin Jo, Hyejin Joo, Dong-Hyun Youn, Jin Mook Kim, Young-Ki Hong, Na Young Lim, Kwan Soo Kim, Su-Jeong Park, Sun Ok Choi   +8 more
doaj   +1 more source