Results 51 to 60 of about 5,794,088 (264)

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

Polysaccharides in Ocular Drug Delivery [PDF]

, 2019
Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies.
Arto Urtti, Skorik, Yury A., Yury A. Skorik, Poshina, Daria, Urtti, Arto, Dubashynskaya, Natallia, Raik, Sergei, Sergei Raik, Daria Poshina, Natallia Dubashynskaya, Yury A. Skorik   +10 more
core   +1 more source

Optimization of an LC–MS/MS analytical method for strychnine in livestock and fishery products

Applied Biological Chemistry
Strychnine, an alkaloid recognized for its antagonist effects on glycine and acetylcholine receptors, is highly toxic and banned in several countries. It is also set to restricted in Republic of Korea from 2024, creating a need for a quantitative test ...
Jin Ha Sim, Hyesu Lee, Ji Young Kim, So–Ra Park, Gui–Hyun Jang, Miok Eom   +5 more
doaj   +1 more source

Drug safety evaluation of intravitreal triamcinolone acetonide

, 2011
Introduction: Triamcinolone acetonide (TA) is a steroidal drug that has been widely administered intravitreally for retinal and choroidal conditions. Safety of steroidal products for intraocular use is essential because of their risk of ocular adverse ...
A. D. Giulio, SARAO, Valentina, Paolo Lanzetta, LANZETTA, Paolo, Valentina Sarao, VERITTI, Daniele, Daniele Veritti, Andrea Di Giulio   +7 more
core   +1 more source

Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system. [PDF]

, 2013
BACKGROUND: Drug-related adverse events remain an important cause of morbidity and mortality and impose huge burden on healthcare costs. Routinely collected electronic healthcare data give a good snapshot of how drugs are being used in 'real-world ...
van der Lei Johan, Sturkenboom, Miriam, EU-ADR consortium, Lars Pedersen (65617), Lorenza Scotti, Paul Avillach (173608), Furlong L, Sturkenboom, M., Helgee Ernst Ahlberg, Avillach, P, Gini R, Scott Boyer (173647), Avillach, P. (Paul), Pedersen, L. (Lars), Miriam Sturkenboom (408749), Mazzaglia, G, Mestres J, Mestres, Jordi, Bauer Mehren, A, Scotti, L, Picelli, G. (Gino), Ernst Ahlberg Helgee (173638), José Luis Oliveira (451346), Prieto-Merino D, Scotti, Lorenza, Coloma PM, Furlong, L.I. (Laura), Mazzaglia Giampiero, Gino Picelli (451351), Matthews, J, Herings, Ron, Giampiero Mazzaglia, Johan van der Lei, Matthews J, Matthews, J.N. (Justin Neil), Mestres i López, Jordi, Kors, J, Sanz, F, David Prieto-Merino (294768), van Mulligen, Erik, Prieto-Merino David, Molokhia M, Picelli G, Mazzaglia, Giampiero, Schuemie, Martijn J, Miriam Sturkenboom, Gini Rosa, Schuemie, Martijn J., Scotti L, van Mulligen, E, van Mulligen E, Prieto-Merino, David, Gianluca Trifirò, Sanz Ferran, Molokhia Mariam, Molokhia, Mariam, Gini, R, Martijn J. Schuemie (257191), Sturkenboom, M.C.J.M. (Miriam), Sanz F, Helgee, E.A. (Ernst Ahlberg), Helgee, EA, Martijn J Schuemie, Rosa Gini (451348), Molokhia, M. (Mariam), Schuemie MJ, Prieto-Merino, D. (David), Coloma Preciosa M., Molokhia, M, Johan van der Lei (451352), Justin Matthews, Mestres Jordi, Jordi Mestres (168498), Scotti Lorenza, Anna Bauer-Mehren, van der Lei, Johan, Schuemie, Martijn, Mazzaglia, G. (Giampiero), Paul Avillach, Erik van Mulligen, Oliveira JL, Sturkenboom, MCJM, Lorenza Scotti (365932), Jordi Mestres, Furlong Laura, Erik van Mulligen (451345), Helgee EA, Herings, R.M.C. (Ron), Trifirò, Gianluca, Laura Furlong, Boyer, S, Picelli, Gino, Coloma, Preciosa M., Avillach Paul, Schuemie Martijn J., Mazzaglia G, Lars Pedersen, Ferran Sanz (89706), Bauer-Mehren Anna, David Prieto-Merino, van der Lei, J, Boyer, Scott, Furlong, Laura I., 1971-, Preciosa M. Coloma (451342), Matthews Justin, Prieto Merino, D, Coloma, P.M. (Preciosa), Ferran Sanz, Sturkenboom M, Kors, Jan; id_orcid, Oliveira, J, Picelli, G, Mulligen, E.M. (Erik) van, Jan Kors, Kors Jan, Lei, J. (Johan) van der, Trifirò G, Herings, R, Prieto-Merino, D, Justin Matthews (451347), Kors, Jan, Lei, Johan, Trifirò, G. (Gianluca), ?, ?, Gini, R. (Rosa), Rosa Gini, van der Lei J, Coloma, Preciosa M, Bauer-Mehren, A. (Anna), Jan Kors (390655), Picelli Gino, Scott Boyer, Avillach, Paul, Coloma, Preciosa, Gini, Rosa, Mariam Molokhia, Martijn J. Schuemie, Oliveira, JL, Ernst Ahlberg Helgee, Helgee, Ernst Ahlberg, Gino Picelli, Sturkenboom Miriam, Oliveira, José Luis, Bauer-Mehren, A, Bauer-Mehren A, Ron Herings (451349), Pedersen, L, Boyer S, Mestres, J, Pedersen, Lars, van Mulligen Erik, Oliveira José Luis, Coloma, P, Mestres, J. (Jordi), Pedersen Lars, Boyer, S. (Scott), Matthews, Justin, Herings Ron, Kors J, Mariam Molokhia (54874), Schuemie, M.J. (Martijn), Sanz, Ferran, Kors, J.A. (Jan), Anna Bauer-Mehren (173597), Pedersen L, Boyer Scott, Trifirò, G, Preciosa M Coloma, Scotti, L. (Lorenza), José Luis Oliveira, Helgee, E, Ron Herings, Gianluca Trifirò (451343), Sanz, F. (Ferran), Furlong, L, Oliveira, J.L. (José Luis), Preciosa M. Coloma, Schuemie, M, Laura Furlong (451344), Avillach P, Furlong, Laura, Bauer-Mehren, Anna, Giampiero Mazzaglia (451350), Trifirò Gianluca, Herings R, TRIFIRO', Gianluca, EU ADR consortium, van Mulligen, Erik; id_orcid, Bauer Mehren A, Prieto Merino D   +189 more
core   +1 more source

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

Scientific Reports, 2021
Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays for SLCs are based on the uptake of radiolabeled or fluorescent substrates.
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman   +4 more
doaj   +1 more source

Rewarding and Reinforcing Effects of 25H-NBOMe in Rodents

Brain Sciences, 2022
The drug 25H-NBOMe is a new psychoactive substance (NPS). The use of these substances is likely to pose a threat to public health because they elicit effects similar to those of known psychoactive substances with similar chemical structures.
Cheolmin Jo, Hyejin Joo, Dong-Hyun Youn, Jin Mook Kim, Young-Ki Hong, Na Young Lim, Kwan Soo Kim, Su-Jeong Park, Sun Ok Choi   +8 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source