Results 31 to 40 of about 5,794,088 (264)

Risk of aortic aneurysm and aortic dissection with the use of fluoroquinolones in Korea: a nested case–control study

BMC Cardiovascular Disorders, 2022
Background Recent studies have raised concern about the association of fluoroquinolones with an increased risk of aortic aneurysm and aortic dissection. We aimed to evaluate such risk in a Korean population.
Nayeong Son, Eunmi Choi, Soo Youn Chung, Soon Young Han, Bonggi Kim   +4 more
doaj   +1 more source

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

ALTEX: Alternatives to Animal Experimentation, 2022
Drug-induced neurotoxicity is a leading cause of safety-related attrition for therapeutics in clinical trials, often driven by poor predictivity of preclinical in vitro and in vivo models of neurotoxicity.
Qin Wang, Jennifer D. Cohen, Tomoya Yukawa, Heather Estrella, Chris Leonard, Jairo Nunes, Colin Choi, Nibha Mishra, Lauren Lewis, Kevin S. Baker, Kazuhiro Kuga, Yvonne P. Dragan, Matthew P. Wagoner   +12 more
doaj   +1 more source

Federated analyses of multiple data sources in drug safety studies

, 2022
Purpose Studies of rare side effects of new drugs with limited exposure may require pooling of multiple data sources. Federated Analyses (FA) allow real-time, interactive, centralized statistical processing of individual-level data from different data ...
Ljung, Rickard, Svennblad, Bodil, Igl, Wilmar, Peter Wilén, Bénédicte Delcoigne, Gedeborg, Rolf, Wilén, Peter, Feltelius, Nils, Karl Michaëlsson, Rickard Ljung, Nils Feltelius, Delcoigne, Benedicte, Wilmar Igl, Bodil Svennblad, Rolf Gedeborg, Michaëlsson, Karl, Delcoigne, B,, Igl, Wilmar,, Gedeborg, R, Michaelsson, K, Ljung, Rickard,, Delcoigne, Benedicte,, Feltelius, Nils,, Feltelius, N, Wilen, P, Gedeborg, Rolf,, Igl, W, Ljung, R,, Svennblad, B, Wilén, Peter,, Michaëlsson, Karl,, Svennblad, Bodil,   +31 more
core   +1 more source

3DDPDs: describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors

Journal of Cheminformatics, 2023
Proteochemometric (PCM) modelling is a powerful computational drug discovery tool used in bioactivity prediction of potential drug candidates relying on both chemical and protein information.
Marina Gorostiola González, Remco L. van den Broek, Thomas G. M. Braun, Magdalini Chatzopoulou, Willem Jespers, Adriaan P. IJzerman, Laura H. Heitman, Gerard J. P. van Westen   +7 more
doaj   +1 more source

Hospital drug safety - role of the pharmacists [PDF]

, 2005
Medication errors and adverse drug reactions are frequent in hospitalized patients. The principle aim of my dissertation was to review the existing data about frequency and risk factors of these findings and to propose measures for their reduction ...
Krähenbühl-Melcher, Anita Maria
core   +1 more source

Systematic review of spontaneous reports of myocarditis and pericarditis in transplant recipients and immunocompromised patients following COVID-19 mRNA vaccination

BMJ Open, 2022
Objectives To determine whether spontaneous reporting rates of myocarditis and pericarditis differed in immunocompromised patients compared with the whole population overall, and in terms of demographics, vaccine dose and time-to-onset.Design Systematic ...
Saad Shakir, Samantha Lane, Alison Yeomans   +2 more
doaj   +1 more source

Cognitive Safety is Largely Ignored in Clinical Drug Trials: A Study of Registered Study Protocols

Background and Objective: The number of reports on suspected drug-induced memory impairment submitted to the US Food and Drug Administration increased 30-fold from 2000 to 2022. Drugs are the most common cause of reversible dementia.
Reimers, Arne, Ljung, Hanna, Reimers, Arne,, Ljung, Hanna,, Lund University.   +4 more
core   +2 more sources

Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

Molecular Medicine, 2020
The Editors-in-Chief would like to alert readers that this article [1] is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Liverpool with respect to the quantitative mass ...
Daniel James Antoine, Dominic P. Williams, Anja Kipar, Hugh Laverty, B. Kevin Park   +4 more
doaj   +1 more source

Reports of myocarditis and pericarditis following mRNA COVID-19 vaccination: a systematic review of spontaneously reported data from the UK, Europe and the USA and of the scientific literature

BMJ Open, 2022
Objectives To combine spontaneously reported data from multiple countries to estimate reporting rate, and better understand risk factors for myocarditis and pericarditis following COVID-19 messenger RNA (mRNA) vaccines.Design Systematic review of ...
Saad Shakir, Samantha Lane, Alison Yeomans   +2 more
doaj   +1 more source

DrugEx v3: scaffold-constrained drug design with graph transformer-based reinforcement learning

Journal of Cheminformatics, 2023
Rational drug design often starts from specific scaffolds to which side chains/substituents are added or modified due to the large drug-like chemical space available to search for novel drug-like molecules.
Xuhan Liu, Kai Ye, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen   +4 more
doaj   +1 more source