Results 11 to 20 of about 8,989,140 (356)
Liver–Heart on chip models for drug safety
APL Bioengineering, 2021 Current pre-clinical models to evaluate drug safety during the drug development process (DDP) mainly rely on traditional two-dimensional cell cultures, considered too simplistic and often ineffective, or animal experimentations, which are costly, time ...
E. Ferrari, M. Rasponi
semanticscholar +1 more source
Drug Safety Data Curation and Modeling in ChEMBL: Boxed Warnings and Withdrawn Drugs
Chemical Research in Toxicology, 2021 The safety of marketed drugs is an ongoing concern, with some of the more frequently prescribed medicines resulting in serious or life-threatening adverse effects in some patients. Safety-related information for approved drugs has been curated to include
Fiona M. I. Hunter +5 more
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2022 Sodium‐glucose cotransporter‐2 (SGLT‐2) inhibitors are antidiabetic drugs with associated safety concerns regarding the risk of genital and urinary tract infections.
Hyeri Yang +6 more
doaj +1 more source
Foods, 2023 Chlorothalonil is an organochlorine fungicide that blocks the respiratory process of cells and persists in agricultural products because it is used extensively to prevent fungal diseases. An analytical method of chlorothalonil using the modified QuEChERS
Da-Young Yun +4 more
doaj +1 more source
Mitochondrial DNA. Part B. Resources, 2021 Curcuma longa, C. wenyujin and C. phaeocaulis are important herbal medicine which of rhizomatous herbaceous perennial plant of the family Zingiberaceae.
Min-Kyeoung Kim +5 more
doaj +1 more source
Skin Sensitization Evaluation of Carbon-Based Graphene Nanoplatelets
Toxics, 2021 Graphene nanoplatelets (GNPs) are one of the major types of carbon based nanomaterials that have different industrial and biomedical applications. There is a risk of exposure to GNP material in individuals involved in their large-scale production and in ...
Sung-Hyun Kim +9 more
doaj +1 more source
Genes and Environment, 2022 Background Several rodent models with chemically induced colon cancer have been developed. Among these models, dextran sulfate sodium (DSS), a colitis inducer, combined with azoxymethane as a colon mutagenic carcinogen, is commonly used.
Atsushi Hakura +4 more
doaj +1 more source
The Research of Toxicity and Sensitization Potential of PEGylated Silver and Gold Nanomaterials
Toxics, 2021 Polyethylene glycol (PEG) is a polymer used for surface modification of important substances in the modern pharmaceutical industry and biopharmaceutical fields.
Dong-Han Lee +7 more
doaj +1 more source
UnCorrupt SMILES: a novel approach to de novo design
Journal of Cheminformatics, 2023 Generative deep learning models have emerged as a powerful approach for de novo drug design as they aid researchers in finding new molecules with desired properties.
Linde Schoenmaker +3 more
doaj +1 more source