Results 11 to 20 of about 4,880,179 (312)

o-Aminoazotoluene, 7,12-dimethylbenz[a]anthracene, and N-ethyl-N-nitrosourea, which are mutagenic but not carcinogenic in the colon, rapidly induce colonic tumors in mice with dextran sulfate sodium-induced colitis

open access: yesGenes and Environment, 2022
Background Several rodent models with chemically induced colon cancer have been developed. Among these models, dextran sulfate sodium (DSS), a colitis inducer, combined with azoxymethane as a colon mutagenic carcinogen, is commonly used.
Atsushi Hakura   +4 more
doaj   +1 more source

The Research of Toxicity and Sensitization Potential of PEGylated Silver and Gold Nanomaterials

open access: yesToxics, 2021
Polyethylene glycol (PEG) is a polymer used for surface modification of important substances in the modern pharmaceutical industry and biopharmaceutical fields.
Dong-Han Lee   +7 more
doaj   +1 more source

Deciphering the scopolamine challenge rat model by preclinical functional MRI

open access: yesScientific Reports, 2021
During preclinical drug testing, the systemic administration of scopolamine (SCO), a cholinergic antagonist, is widely used. However, it suffers important limitations, like non-specific behavioural effects partly due to its peripheral side-effects ...
Gergely Somogyi   +5 more
doaj   +1 more source

A systematic, concept-based method of developing the exposure measure for drug safety and effectiveness studies.

open access: yes, 2022
PURPOSE In drug safety and effectiveness studies based on secondary data, the choice of an appropriate exposure measure for a given outcome can be challenging.
Brasher, Penelope M A   +5 more
core   +1 more source

UnCorrupt SMILES: a novel approach to de novo design

open access: yesJournal of Cheminformatics, 2023
Generative deep learning models have emerged as a powerful approach for de novo drug design as they aid researchers in finding new molecules with desired properties.
Linde Schoenmaker   +3 more
doaj   +1 more source

Hospital drug safety - role of the pharmacists [PDF]

open access: yes, 2005
Medication errors and adverse drug reactions are frequent in hospitalized patients. The principle aim of my dissertation was to review the existing data about frequency and risk factors of these findings and to propose measures for their reduction ...
Krähenbühl-Melcher, Anita Maria
core   +1 more source

Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]

open access: yes, 2013
Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa AA   +3 more
core   +1 more source

Prevalence and Characteristics of Antimicrobial-Resistant Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus from Retail Meat in Korea

open access: yesFood Science of Animal Resources, 2020
This study was to investigate the prevalence and characteristics of antimicrobial-resistant Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) from 4,264 retail meat samples including beef, pork, and chicken in Korea between 2013 and 2018 ...
Yong Hoon Kim   +4 more
doaj   +1 more source

Skin Sensitization Potential and Cellular ROS-Induced Cytotoxicity of Silica Nanoparticles

open access: yesNanomaterials, 2021
Nowadays, various industries using nanomaterials are growing rapidly, and in particular, as the commercialization and use of nanomaterials increase in the cosmetic field, the possibility of exposure of nanomaterials to the skin of product producers and ...
Sung-Hyun Kim   +7 more
doaj   +1 more source

SAFETY OF HERBAL DRUGS

open access: yesJournal of Research in Pharmacy, 2023
The quality and efficacy of treatment in the healthcare industry have dramatically changed over the last century as a consequence of advancements in medical science, mass manufacturing of chemically synthesized pharmaceuticals, and technologies. However, due to the fact that natural treatments are more accessible but also less expensive than prescribed
openaire   +3 more sources

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