Results 11 to 20 of about 927,468 (265)

o-Aminoazotoluene, 7,12-dimethylbenz[a]anthracene, and N-ethyl-N-nitrosourea, which are mutagenic but not carcinogenic in the colon, rapidly induce colonic tumors in mice with dextran sulfate sodium-induced colitis

open access: yesGenes and Environment, 2022
Background Several rodent models with chemically induced colon cancer have been developed. Among these models, dextran sulfate sodium (DSS), a colitis inducer, combined with azoxymethane as a colon mutagenic carcinogen, is commonly used.
Atsushi Hakura   +4 more
doaj   +1 more source

The Research of Toxicity and Sensitization Potential of PEGylated Silver and Gold Nanomaterials

open access: yesToxics, 2021
Polyethylene glycol (PEG) is a polymer used for surface modification of important substances in the modern pharmaceutical industry and biopharmaceutical fields.
Dong-Han Lee   +7 more
doaj   +1 more source

Deciphering the scopolamine challenge rat model by preclinical functional MRI

open access: yesScientific Reports, 2021
During preclinical drug testing, the systemic administration of scopolamine (SCO), a cholinergic antagonist, is widely used. However, it suffers important limitations, like non-specific behavioural effects partly due to its peripheral side-effects ...
Gergely Somogyi   +5 more
doaj   +1 more source

UnCorrupt SMILES: a novel approach to de novo design

open access: yesJournal of Cheminformatics, 2023
Generative deep learning models have emerged as a powerful approach for de novo drug design as they aid researchers in finding new molecules with desired properties.
Linde Schoenmaker   +3 more
doaj   +1 more source

Prevalence and Characteristics of Antimicrobial-Resistant Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus from Retail Meat in Korea

open access: yesFood Science of Animal Resources, 2020
This study was to investigate the prevalence and characteristics of antimicrobial-resistant Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) from 4,264 retail meat samples including beef, pork, and chicken in Korea between 2013 and 2018 ...
Yong Hoon Kim   +4 more
doaj   +1 more source

Skin Sensitization Potential and Cellular ROS-Induced Cytotoxicity of Silica Nanoparticles

open access: yesNanomaterials, 2021
Nowadays, various industries using nanomaterials are growing rapidly, and in particular, as the commercialization and use of nanomaterials increase in the cosmetic field, the possibility of exposure of nanomaterials to the skin of product producers and ...
Sung-Hyun Kim   +7 more
doaj   +1 more source

Risk of aortic aneurysm and aortic dissection with the use of fluoroquinolones in Korea: a nested case–control study

open access: yesBMC Cardiovascular Disorders, 2022
Background Recent studies have raised concern about the association of fluoroquinolones with an increased risk of aortic aneurysm and aortic dissection. We aimed to evaluate such risk in a Korean population.
Nayeong Son   +4 more
doaj   +1 more source

Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles

open access: yesToxics, 2021
Zinc oxide nanoparticles (ZnO NPs) are used in various industries such as food additives, cosmetics, and biomedical applications. In this study, we evaluated lung damage over time by three types of ZnO NPs (L-serine, citrate, and pristine) following the ...
Ayoung Jung   +6 more
doaj   +1 more source

Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric Techniques

open access: yesApplied Sciences, 2023
Even though synthetic colorants can cause side effects such as allergies and pigmentation, they have not been sufficiently researched. Herein, high-performance liquid chromatography, liquid chromatography-tandem mass spectrometry, and liquid ...
Kyoung-Moon Han   +6 more
doaj   +1 more source

Systematic review of spontaneous reports of myocarditis and pericarditis in transplant recipients and immunocompromised patients following COVID-19 mRNA vaccination

open access: yesBMJ Open, 2022
Objectives To determine whether spontaneous reporting rates of myocarditis and pericarditis differed in immunocompromised patients compared with the whole population overall, and in terms of demographics, vaccine dose and time-to-onset.Design Systematic ...
Saad Shakir   +2 more
doaj   +1 more source

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