Results 131 to 140 of about 835,419 (313)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Advances and Challenges in Drug Screening for Cancer Therapy: A Comprehensive Review. [PDF]

Bioengineering (Basel)
Motohashi S, Katsuta E, Ban D.
europepmc   +1 more source

DNA-Encoded Library Screening Identifies CDK2-Targeting Lead Compounds with Favorable Drug-like Properties for Anticancer Development

Liping Zhou, Yong Ju, Zhijuan Cao, Sheng Cai, Jiayuan Su, Jianzhong Lu   +5 more
openalex   +1 more source

Identification of Targetable Virulence Factor and Drug Screening For Bacterial Pneumonia

, 2015
Iosr Journals, Nikita Chordia Ravikant Yadav   +1 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Engineering Human 3D Cardiac Tissues for Predictive Functional Drug Screening. [PDF]

Pharmaceutics
Baruch ES, Rosner D, Riska E, Yadid M, Shapira A, Dvir T.   +5 more
europepmc   +1 more source

Thermal shift assay (TSA)-based drug screening strategy for rapid discovery of inhibitors against the Nsp13 helicase of SARS-CoV-2

Zoonoses, Animals and
openalex   +1 more source

Assessment of drugs against Cryptosporidium parvum using a simple in vitro screening method [PDF]

, 1999
A. Armson
openalex   +1 more source

In vitro functional models for human liver diseases and drug screening: beyond animal testing

, 2022
Alessia Paradiso, Marina Volpi, Chiara Rinoldi, Nehar Celikkin, Nicola Contessi Negrini, Muge Bilgen, Giorgio Dallera, Filippo Pierini, Marco Costantini, Wojciech Święszkowski, Silvia Farè   +10 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source