Results 141 to 150 of about 835,419 (313)

Construction and application of pancreatic exocrine organoid and spheroid for drug screening and precision medicine. [PDF]

Front Cell Dev Biol
Tan X, Huang B, Yang X, Wang P, Hu L.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The applications of single-cell multiomics in drug screening. [PDF]

Pharm Sci Adv
Xue Q, Hu H, Wang R, Wu F, Xiong H.
europepmc   +1 more source

ATPS-28COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS [PDF]

, 2015
Natalie Grinshtein, Constanza Rioseco, David Uehling, Asma M. Aman, Artee Luchman, Donna L. Senger, Steve Robbins, G. Cairncross, Alessandro Datti, Jeffrey L. Wrana, Steve Jones, Marco A. Marra, Mike Moran, Rima Al‐awar, Samuel Weiss, David R. Kaplan   +15 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Predicted peptide scaffolds for drug screening in endometrial cancer organoids. [PDF]

Sci Rep
Zhang M, Wan Y, Li D.
europepmc   +1 more source

Organiod-on-chip systems for drug screening and disease modeling

Praveen Kumar Dasari, Harika Nandhikola, Lakshmi Rajaboina, Krishna Durga Peddini, Vishnu Vardhan Bellamkonda, Anil Gundepuri   +5 more
openalex   +1 more source

Network-based screening identifies sitagliptin as an antitumor drug targeting dendritic cells [PDF]

Ian-Ian Ng, Jiaqi Zhang, Tingzhong Tian, Peng Qi, Zheng Huang, Kaimin Xiao, Xiyue Yao, Lui Ng, Jianyang Zeng, Haidong Tang   +9 more
openalex   +1 more source

Commentary on Gelberg et al. 2015: Alcohol and other drug screening and brief intervention – evidence in crisis [PDF]

, 2015
Richard Saitz
openalex   +1 more source

Suppl. Table 1 from Adapting a Drug Screening Platform to Discover Associations of Molecular Targeted Radiosensitizers with Genomic Biomarkers

, 2023
Qi Liu, Meng Wang, Ashley M. Kern, Saman Khaled, Jing Han, Beow Y. Yeap, Theodore S. Hong, Jeff Settleman, Cyril H. Benes, Kathryn D. Held, Jason A. Efstathiou, Henning Willers   +11 more
openalex   +1 more source