Results 181 to 190 of about 835,419 (313)

One-Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids. [PDF]

Adv Sci (Weinh)
Shin H, An Y, Lee JH, Kim JH, Prasad R, Kim KT, Kang HC, Sun W, Cho SW, Cho IJ.   +9 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Patient-derived organoids based on targeted biopsy of primary prostate cancer: development, identification, and drug screening. [PDF]

Ann Med
Qian J, Peng S, Gao J, Fu Y, Huang H, Wu C, Gan W, Qiu X, Guo H.   +8 more
europepmc   +1 more source

Employee Drug Screening [PDF]

AAOHN Journal, 1986
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Development of a liquid overlay-based three-dimensional cell culture panel for drug screening applications. [PDF]

Sci Rep
Depresle M, Daumar P, Goisnard A, Roux M, Aubel C, Penault-Llorca F, Mounetou E, Bamdad M.   +7 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Neurofibromatosis Type 1 and the Search for Effective Tumor Therapies Using High-Throughput Drug Screening. [PDF]

Curr Oncol
Bouley SJ, Housden BE, Walker JA.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Development and Application of a Pseudovirus-Based Assay for Modelling SARS-CoV-2 Spike Protein Mediated Drug Screening. [PDF]

Int J Mol Sci
Khasanov SA, Esaulkova IL, Volobueva AS, Slita AV, Kriger DV, Tentler D, Yarovaya OI, Sokolova AS, Gorshkov AN, Dolgova AS, Lavrentieva IN, Dedkov VG, Salakhutdinov NF, Zarubaev VV.   +13 more
europepmc   +1 more source