Results 201 to 210 of about 942,716 (313)

Analysis of postmortem dermal extracts is an efficient illicit drug screening method supporting forensic medicine. [PDF]

Sci Rep
Wasinger D, Stolz K, Wolf M, Gmeiner G, Bileck A, Hagn G, Meier-Menches SM, Kanz F, Gerner C.   +8 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

A compatible gravity-driven organoid perfusion (GDOP) platform for drug screening with sensitivity and toxicity process evaluation. [PDF]

Commun Biol
Wang S, Zhang X, Ma H, Lu L, Jiang H, Bai Y, Chang X, Wang J, Yang T, Luo G.   +9 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Personalized Drug Screening and Risk Assessment in Patient-Derived Gastroenteropancreatic Neuroendocrine Neoplasms.

J Clin Endocrinol Metab
Auernhammer CJ, Wang K, Maccio U, Knösel T, Hungbauer MP, Schilbach K, Maurer J, Peischer L, Reul A, Kuzmenko E, Luca E, Hamati J, Vetter D, Oberholzer J, Fritsch R, Pacak K, Grossman AB, Beuschlein F, Reincke M, Hantel C, Zitzmann K, Nölting S.   +21 more
europepmc   +1 more source

AI-integrated microfluidics for drug screening: From single cell to organ-on-a-chip. [PDF]

Acta Pharm Sin B
Yin H, Li Z, Shen Z, Wang S, Du N, Cheng S, Zhou J, Li Y, Jia Y, Li Y.   +9 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Engineering Human 3D Cardiac Tissues for Predictive Functional Drug Screening. [PDF]

Pharmaceutics
Baruch ES, Rosner D, Riska E, Yadid M, Shapira A, Dvir T.   +5 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A ZIF-8-modified electrochemical biosensor for sensitive Aβ aggregation monitoring and Alzheimer's disease drug screening. [PDF]

RSC Adv
Chien SC, Chien YC, Wang HJ, Chen JC.
europepmc   +1 more source