Results 221 to 230 of about 942,716 (313)

Machine learning-based identification of key genes underlying sex differences in hepatocellular carcinoma and targeted drug screening. [PDF]

Biomed Rep
Wang Z, Ning J, Zhang H, Ruan Q, Zhao Y, Qu R, Lv C, Wu Y, Liu W, Yang X, Li Z, Liang Y, Zhang Y.   +12 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Patient-derived d-MMR/MSI phenotype urachal cancer organoids for personalized drug screening. [PDF]

Front Oncol
Zhang K, Li X, Zhang Z, Zhang N, Yao X, Liu R.   +5 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Human retinal organoid model of disease-relevant photoreceptor cell death amenable to drug screening. [PDF]

Cell Death Dis
Parween S, Saviola AJ, Howell AC, Varghese S, Galindo DC, Vergara MN.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Drug screening.

Journal of athletic training, 2010
openaire   +1 more source

Advances in high-throughput drug screening based on pharmacotranscriptomics. [PDF]

J Adv Res
Qiao L, Huo X, Huang W, Wang Z, Ren Y, Liu Y, Li Q, Zhang Y.   +7 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Human iPSC-Based in Vitro Cardiovascular Tissue Models for Drug Screening Applications. [PDF]

Curr Cardiol Rep
Anand S, Chen G, Khanna A, Huang NF.
europepmc   +1 more source