Results 241 to 250 of about 942,716 (313)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Microfluidic Perfusable Pathological Vasculature for Atherosclerosis Drug Screening. [PDF]

Research (Wash D C)
Liu J, Zhu M, Bai N, Huang N, Zhang W, Yang Z, Wang Y.   +6 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Individualized drug screening in cholangiocarcinoma using organoid models and patient-derived tumor xenograft. [PDF]

BMC Cancer
Han P, Zhu L, Tong W, Liu S, Xu Y, Wang L, Wang T, Zhao T, Miao Y, Chi H, Cui T, Wang Z, Yang L, Zhang Y.   +13 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

A vascularized 3D bioengineered lung tumor model for anticancer drug screening. [PDF]

Cancer Cell Int
Wang M, Ye Y, Yuan R, Zheng X, Li X, Han Y, Guo L, Lei T, Wang X.   +8 more
europepmc   +1 more source

Development, Expansion, and Histological Characterization of Patient-Derived Liver Organoids for Drug Screening and Disease Modeling. [PDF]

Bio Protoc
De Siervi S, Mantovani S, Oliviero B, Mondelli MU, Di Noia M, Soldani C, Franceschini B, De Luca F, Maestri M, Corallo S, Lolicato M, Cannito S, Turato C.   +12 more
europepmc   +1 more source

Bridging phenotype and function in bladder cancer using immuno-competent organoids and ex vivo drug screening. [PDF]

J Exp Clin Cancer Res
Frascolla C, Mastroianni R, Macedo-Silva C, De Menna M, Orlandi G, Covino DA, Minoli M, Radic M, La Manna F, Pulito C, Vaccarella S, Goeman F, Ciuffreda L, Allegretti M, Seiler R, Kiss B, De Pascale V, Runci F, Calabrò F, Vinik Y, Lev S, Strano S, Fanciulli M, Arteni BAM, Di Martino S, Russo A, Donzelli S, Kruithof-de Julio M, Blandino G, Simone G.   +29 more
europepmc   +1 more source

An iPSC-derived model for drug screening in cerebral small vessel disease. [PDF]

J Cereb Blood Flow Metab
Granata A, Al-Thani M, Goodwin-Trotman M, Smith DM, Van Agtmael T, Markus HS.   +5 more
europepmc   +1 more source