Results 261 to 270 of about 942,716 (313)
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Screening of drug candidates for their drug–drug interaction potential
Current Opinion in Chemical Biology, 2001Within the past year, additional papers have been published that focus on higher-throughput drug-interaction screening. Some papers have described enzyme assays that can be used to evaluate inhibition or induction of the human cytochrome P450s. At the same time, numerous investigators have developed computational (in silico) methods to predict ...
A D, Rodrigues, J H, Lin
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Computerized Drug-drug Interaction Screening System
American Journal of Health-System Pharmacy, 1978A pharmacy automated drug interaction screening (PADIS) system is described which detects possible drug interactions by screening patient medication profiles. The data base contains approximately 24,000 drug interaction combinations of drugs marketed in the U.S.
C W, Greenlaw, D D, Zellers
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Anticoccidial drugs: Screening methods
Experimental Parasitology, 1970Abstract A review of thirteen primary screens for anticoccidial activity utilizing Eimeria tenella as the screening organism in chicks reveals differences among the following: breeds of birds used, number and sex of birds used per compound; number of oocysts used for inoculation; time of oocyst administration; experimental diets; and criteria used ...
R F, Shumard, M E, Callender
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Pharmacogenetic screening and therapeutic drugs
Clinica Chimica Acta, 2002Pharmacogenetics is the science of the influence of heredity on pharmacological response.The cost of severe adverse drug reactions in individuals has been estimated in the US alone to be in excess of US$4 billion. It has been argued that in a significant proportion of cases, the efficacy and toxicity profiles of drug therapy would be substantially ...
Werner, Steimer, Julia M, Potter
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Biometrika, 1963
The problem of drug screening is to select from a large number of drugs those having some particular desirable biological effect. A sample of laboratory animals are treated with the drug and some measure of the effect on each animal is obtained. These experimental results lead to the decision to 'accept' or 'reject' the drug.
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The problem of drug screening is to select from a large number of drugs those having some particular desirable biological effect. A sample of laboratory animals are treated with the drug and some measure of the effect on each animal is obtained. These experimental results lead to the decision to 'accept' or 'reject' the drug.
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SCREENING FOR ALCOHOL AND DRUG ABUSE
Medical Clinics of North America, 1997The purpose of this article is to review screening for substance use disorders in health care settings. The epidemiology of alcohol and other drug abuse is briefly reviewed, followed by a discussion of the principles underlying whether or not screening is warranted. Different screening instruments and strategies are then described.
J B, Schorling, D, Buchsbaum
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Cancer-on-a-chip for Drug Screening
Current Pharmaceutical Design, 2019: The oncology pharmaceutical research spent a shocking amount of money on target validation and drug optimization in preclinical models because many oncology drugs fail during clinical trial phase III. One of the most important reasons for oncology drug failures in clinical trials may due to the poor predictive tool of existing preclinical models ...
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Urine drug screening in adolescents
Pediatric Clinics of North America, 2002The urine drug screen is an important tool in adolescent medicine. Several ethical, and numerous technical, issues are associated with the use of this tool. The nature and limitations of the specific tests of which the screen is composed must be known to the physician. Two-way communication with the laboratory, both before the test is ordered and after
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Drug screening in the athletic setting
Current Problems in Pediatrics, 1994Considerable energy and money are being spent on drug screening nationally, both in the workplace and the athletic arena. Many legal questions remain unanswered because there are so many different kinds of drug screening programs, and many of the issues have not been tested in court.
G L, Landry, P K, Kokotailo
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Screening of liver-targeted drugs
Expert Opinion on Drug Discovery, 2008Cancer is a genetic disease of somatic cells arising from accumulation of genetic changes, and inhibition of oncogenes and restoration of tumor suppressor genes will be of great benefit for cancer patients.Microarray technology provides a unique opportunity to identify new molecular targets, and many researchers have applied this technology in studies ...
Yutaka, Midorikawa +2 more
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