Results 11 to 20 of about 120,380 (317)

In vitro anticancer studies of a small library of cyclic lipopeptides against the human cervix adenocarcinoma HeLa cells [PDF]

Journal of the Serbian Chemical Society
Various cyclic lipopeptides (CLPs, 23 compounds) were tested for their antitumor potential against human cervix adenocarcinoma HeLa cells. From the fast screening (tested concentrations: 0.01 and 10 μM) compound 10 ((12S,6S,10S,13S)-6-((R)-sec-butyl)-7 ...
Hmedat Ali N., Morejón Micjel C., Rivera Daniel G., Pantelić Nebojša Đ., Wessjohann Ludger A., Kaluđerović Goran N.   +5 more
doaj   +2 more sources

Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth

Cell Communication and Signaling
Background Epidermal growth factor receptor (EGFR) T790M mutation often occurs during long durational erlotinib treatment of non-small cell lung cancer (NSCLC) patients, leading to drug resistance and disease progression.
Rui Zhou, Ziqian Liu, Tongtong Wu, Xianwei Pan, Tongtong Li, Kaiting Miao, Yuru Li, Xiaohui Hu, Haigang Wu, Andrew M. Hemmings, Beier Jiang, Zhenzhen Zhang, Ning Liu   +12 more
doaj   +2 more sources

RESEARCH PROGRESS IN INDIVIDUALIZED DRUG SCREENING TECHNOLOGY FOR PATIENTS WITH TUMORS [PDF]

精准医学杂志, 2023
In China, the incidence of tumors is increasing year by year, with the number of patients with new tumors ranking first in the world. Currently, tumors are usually treated with surgery combined with radiotherapy, chemotherapy, targeted therapy, or ...
WU Xiao-xiao, LIU Meiyou, PENG Li, CHENG Lianghua, WANG Fan, WANG Jingwen, JIA Yanyan
doaj   +1 more source

Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To characterize the anatomy of the fruit and leaf and the presence of phytocompounds. To evaluate the antitumor and antimicrobial activity of ethanolic extract of Garcinia mangostana L.
Bruna Lais Almeida Cunha, Jerônimo Pereira de França, Andrea Aparecida de Fátima Souza Moraes, Alba Lucilvânia Fonseca Chaves, Silvana Gaiba, Renato Fontana, Celio Kersul do Sacramento, Lydia Masako Ferreira, Lucimar Pereira de França   +8 more
doaj   +1 more source

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1:a novel anticancer small-molecule [PDF]

, 2015
Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of ...
Bessa, Cláudia, Bisio, Alessandra, Fernandes, João, Gomes, Célia, Gomes, Sara, Gonçalves, Jorge, Inga, Alberto, Monteiro, Ângelo, Pereira, Clara, Pereira, Nuno A.L., Queiroz, Glória, Raimundo, Liliana, Reis, Flávio, Santos, Maria M.M., Saraiva, Lucília, Soares, Joana   +15 more
core   +8 more sources

Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening.

PLoS ONE, 2021
This work tries to help overcome the lack of relevant translational screening assays, as a limitation for the identification of novel analgesics for neuropathic pain.
Antón L Martínez, José Brea, Mateo Barro, Xavier Monroy, Manuel Merlos, Javier Burgueño, María Isabel Loza   +6 more
doaj   +1 more source

Identification of Kinase Targets for Enhancing the Antitumor Activity of Eribulin in Triple-Negative Breast Cell Lines

Biomedicines, 2023
Background: Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast cancer, and current treatments are only partially effective in disease control.
Xuemei Xie, Jangsoon Lee, J. Fuson, Huey Liu, T. Iwase, Kyuson Yun, Corina Margain, D. Tripathy, N. Ueno   +8 more
semanticscholar   +1 more source

Drug Repurposing Flubendazole to Suppress Tumorigenicity via PCSK9-dependent Inhibition and Potentiate Lenvatinib Therapy for Hepatocellular Carcinoma

International Journal on Biological Sciences, 2023
Hepatocellular carcinoma (HCC) is one of the most lethal malignant cancers across the world. It has a poor prognosis and lacks effective therapies, especially for patients with advanced-stage cancer, indicating an urgent need for new therapies and novel ...
Wenjiao Jin, Junming Yu, Yang Su, He-chun Lin, Teng-fei Liu, J. Chen, Chao Ge, F. Zhao, Qin Geng, Lin Mao, Shuqing Jiang, Ying Cui, Tao-yang Chen, G. Jiang, Jinjun Li, Chunxiao Miao, Xiuying Xiao, Hong Li   +17 more
semanticscholar   +1 more source

Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE:To evaluate the antitumor and antimicrobial activity of ethanolic extract of Morinda citrifolia L. fruit cultivated in southeastern Brazil.METHODS:Preparation ethanolic extract of the fruit of Morinda citrifoliaL.
Thamyris Candida, Jerônimo Pereira de França, Alba Lucilvânia Fonseca Chaves, Fernanda Andrade Rodrigues Lopes, Silvana Gaiba, Celio Kersul do Sacramento, Lydia Masako Ferreira, Lucimar Pereira de França   +7 more
doaj   +1 more source

Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells

Molecules, 2023
Imidazo[1,2-a]pyridines (IPs) have been studied regarding drug development. The objective of this work was to evaluate the antileukemic capacity of IP derivatives by screening their ability as a pro-oxidant.
Gabriella Teles Burkner, Dhébora Albuquerque Dias, Kamylla Fernanda Souza de Souza, Anna Júlia Papa de Araújo, Denise Caroline Luiz Soares Basilio, Fernanda Tondello Jacobsen, Ana Carolina Rabello de Moraes, Saulo Euclides Silva-Filho, Marcos Filipe de Oliveira Cavalcante, Cassio Augusto de Oliveira Moraes, Sumbal Saba, Maria Lígia Rodrigues Macedo, Edgar Julian Paredes-Gamero, Jamal Rafique, Eduardo Benedetti Parisotto   +14 more
doaj   +1 more source