Results 41 to 50 of about 37,916 (265)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Estudo do efeito antiproliferativo e pró-apoptótico do látex de Croton celtidifolius Baill [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2011Apesar de todos os recursos existentes na atualidade para o tratamento do câncer uma diversidade ...
Biscaro, Fernanda
core  

The use of 3-D cultures for high-throughput screening: the multicellular spheroid model [PDF]

, 2004
Over the past few years, establishment and adaptation of cell-based assays for drug development and testing has become an important topic in high-throughput screening (HTS).
Leoni A. Kunz-Schughart, Ferdinand Hofstaedter, Ebner, Reinhard, Freyer, James P., Kunz-Schughart, Leoni A., Hofstaedter, Ferdinand, James P. Freyer, Reinhard Ebner   +7 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Avaliação da ação citotóxica e antitumoral de cucurbitacinas naturais e derivados semissintéticos [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.Mundialmente, o câncer de pulmão é um dos principais responsáveis pela alta taxa de mortalidade atribuída ...
Silva, Izabella Thaís da
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Efeito antitumoral e antiangiogênico dos extratos bruto e supercríticoo de Bidens pilosa Linné e Casearia sylvestris Swartz [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaO desenvolvimento de novas alternativas terapêuticas, como as que utilizam as plantas medicinais, tem despertado grande ...
Bücker, Nádia Cristina Falcão
core  

Mass Spectrometry of Nucleic Acid Noncovalent Complexes [PDF]

, 2021
International audienceNucleic acids have been among the first targets for antitumor drugs and antibiotics, and with the unveiling of new biological roles in regulation of gene expression, specific DNA and RNA structures have become very attractive ...
Valérie Gabelica, Ghosh, Anirban, Rosu, Frédéric, Benabou, Sanae, König, Alexander, Frédéric Rosu, Sanae Benabou, Debasmita Ghosh, Rosu, Frédéric Johanna R, Gabelica, Valérie, Eric Largy, Largy, Eric, Alexander König, Anirban Ghosh, Ghosh, Debasmita   +14 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

South African marine compounds as anticancer agents [PDF]

, 2006
Includes bibliographical references (leaves 149-163).Oesophageal cancer is the most common cause of cancer related deaths among black males in South Africa.
Whibley, Catherine Evelyn
core