Results 21 to 30 of about 112,008 (305)

Caracterización del perfil de sensibilidad de un panel de líneas celulares para valoración de citotoxicidad in vitro.

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. La valoración de la citotoxicidad in vitro de líneas celulares derivadas de tumores humanos se emplea como bioensayo preliminar para el tamizaje de productos de origen natural con potencial actividad anticancerígena. Objetivo. Fortalecer el
Claudia Jhoana León, Sandra Milena Gómez, Sandra Johanna Morantes, Claudia Patricia Cordero, Fabio Ancízar Aristizábal   +4 more
doaj   +1 more source

Inhibition of histone deacetylase as a treatment for cardiac hypertrophy [PDF]

, 2005
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac ...
Bristow, Michael R., Long, Carlin, McKinsey, Timothy A., Olson, Eric N.   +3 more
core   +1 more source

Drug Repurposing Flubendazole to Suppress Tumorigenicity via PCSK9-dependent Inhibition and Potentiate Lenvatinib Therapy for Hepatocellular Carcinoma

International Journal on Biological Sciences, 2023
Hepatocellular carcinoma (HCC) is one of the most lethal malignant cancers across the world. It has a poor prognosis and lacks effective therapies, especially for patients with advanced-stage cancer, indicating an urgent need for new therapies and novel ...
Wenjiao Jin, Junming Yu, Yang Su, He-chun Lin, Teng-fei Liu, J. Chen, Chao Ge, F. Zhao, Qin Geng, Lin Mao, Shuqing Jiang, Ying Cui, Tao-yang Chen, G. Jiang, Jinjun Li, Chunxiao Miao, Xiuying Xiao, Hong Li   +17 more
semanticscholar   +1 more source

Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo [PDF]

, 2016
Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of ...
Berek, Jonathan S, Chung, Young Min, Hu, Mickey C-T, Ma, Jessica, Park, See-Hyoung, Yang, Qin   +5 more
core   +2 more sources

B-cell lymphoma extra-large (Bcl-xL) is a promising drug target in Merkel cell carcinoma.

British Journal of Dermatology, 2023
BACKGROUND Merkel cell carcinoma (MCC) is an aggressive skin tumor with neuroendocrine differentiation. Immunotherapies are very effective in the treatment of advanced stage MCC patients, but for patients whose tumor cannot be controlled by the immune ...
Kaiji Fan, Nalini Srinivas, Linda Kubat, Jan Gravemeyer, A. Sucker, D. Schadendorf, T. Gambichler, J. Becker   +7 more
semanticscholar   +1 more source

Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

MedComm, 2021
Colorectal cancer (CRC) is one of the most common malignancies currently. Despite advances in drug development, the survival and response rates in CRC patients are still poor.
Xiang‐Peng Tan, Yan He, Yun‐Na Huang, Can‐Can Zheng, Jun‐Qi Li, Qin‐Wen Liu, Ming‐Liang He, Bin Li, Wen‐Wen Xu   +8 more
doaj   +1 more source

Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors [PDF]

, 2017
[Cu(thp)4][PF6] (HydroCuP) is a phosphino copper(I) complex highly soluble and stable in physiological media that has been developed as a possible viable alternative to platinum-based drugs for anticancer therapy.
Ceresa, Cecilia, Esposito, Giovanni, Gandin, Valentina, Indraccolo, Stefano, Marzano, Cristina, Pellei, Maura, Porchia, Marina, Santini, Carlo, Tisato, Francesco   +8 more
core   +3 more sources

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis [PDF]

, 2013
Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity ...
Bailey H. H., Ballestrero A., Bellamy W. T., Betanzos-Lara S., Bozic I., Bushra Qamar, Carew J. S., Castonguay A., Chan J., Constantini P., Dai Y., Degterev A., Dindo D., Doroshow J. H., Dyke M. W. Van, Fagan V., Finnilä S., Frank J. E., Fu Y., Fu Y., Gaiddon C., Garbutcheon-Singh K. B., Hannon M. J., Hartinger C. G., Hileman E. A., Holbeck S., Huo H., Ian Hands-Portman, Isolda Romero-Canelón, Jessica M. Hearn, Jordan M. A., Jungwirth U., Kelland L., Kerr J. F., Kroemer G., Lazebnik Y. A., Liu Z., Liu Z., Liu Z., Lu J.-J., McKeage M. J., Millar A. W., Monneret C., Nagata S., Park G. Y., Paull K., Perchellet E. M., Peter J. Sadler, Petrelli A., Pittella F., Porteous C. M., Pracharova J., Purewal M., Rai S. S., Rixe O., Saraste A., Shoemaker R. H., Shoemaker R. H., Siddik Z., Sidler D., Tsutsui T., Türk D., Van den Bogert C., Zalacaín M., Zhang Y.-W., Zhe Liu, Zhou D.-F., Zhu Z.   +67 more
core   +1 more source

Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization

Molecules, 2018
Some fluoroquinazolinones (A–H) were designed, synthesized and biologically evaluated for their antitumor activity against the two cell lines, MCF-7 and MDA-MBA-231.
Mohamed F. Zayed, Heba S. Rateb, Sahar Ahmed, Osama A. Khaled, Sabrin R. M. Ibrahim   +4 more
doaj   +1 more source

A high-throughput drug combination screen identifies an anti-glioma synergism between TH588 and PI3K inhibitors

Cancer Cell International, 2020
Background Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor. More than half of GBMs contain mutation(s) of PTEN/PI3K/AKT, making inhibitors targeting the PI3K pathway very attractive for clinical investigation ...
Zhen Chen, Chao Chen, Tingting Zhou, Chao Duan, Qianqian Wang, Xiaohui Zhou, Xia Zhang, Fangrong Wu, Yunfen Hua, Fan Lin   +9 more
doaj   +1 more source