Results 11 to 20 of about 37,916 (265)

Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization [PDF]

Molecules, 2018
Some fluoroquinazolinones (A–H) were designed, synthesized and biologically evaluated for their antitumor activity against the two cell lines, MCF-7 and MDA-MBA-231.
Mohamed F. Zayed, Heba S. Rateb, Sahar Ahmed, Osama A. Khaled, Sabrin R. M. Ibrahim   +4 more
doaj   +2 more sources

Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening [PDF]

Frontiers in Physiology, 2017
Introduction: Cell-based assays using three-dimensional (3D) cell cultures may reflect the antitumor activity of compounds more accurately, since these models reproduce the tumor microenvironment better.Methods: Here, we report a comparative analysis of ...
Robson L. F. Amaral, Mariza Miranda, Priscyla D. Marcato, Kamilla Swiech   +3 more
doaj   +3 more sources

Repurposing the Antibacterial Activity of the Drug Teniposide Against Gram-Positive Bacteria [PDF]

Cellular Microbiology
Drug repurposing is sparking considerable interest due to reduced costs and development times. The current study details the screening of teniposide, an antitumor drug, for its antibacterial activity against both Gram-positive and Gram-negative strains ...
Federica Dell’Annunziata, Veronica Folliero, Roberta Della Marca, Francesca Palma, Giuseppina Sanna, Anna De Filippis, Pasquale Pagliano, Aldo Manzin, Gianluigi Franci, Massimiliano Galdiero   +9 more
doaj   +4 more sources

In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles [PDF]

, 2013
Nanoparticles with pH-sensitive behavior may enhance the success of chemotherapy in many cancers by efficient intracellular drug delivery. Here, we investigated the effect of a bioactive surfactant with pH-sensitive properties on the antitumor activity ...
Vinardell, M. Pilar, Vinardell Martínez-Hidalgo, Ma. Pilar, Mitjans, Montserrat, Mitjans Arnal, Montserrat, Infante, María Rosa, Pérez, Lourdes, Infante Martínez-Pardo, Ma. Rosa, Tavano, Lorena, Nogueira, Daniele R., Nogueira, Daniele Rubert, Pérez Muñoz, Lourdes   +10 more
core   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Mottram, JC, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Kita, K, Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Walker, RG, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Brown, E, Malone, K, Turner Nicholas J., Walkinshaw, MD, Blake, DG, Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Nowicki, MW, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Thomson, G, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Grant, KM, Blake, D.G., Malcolm D Walkinshaw, Turner, NJ, Thomson, G.   +59 more
core   +1 more source

Discovery of a Novel Potent Antitumor Molecule, P19G1, by Erlotinib Derivative Libraries Synthesized by Modular Click-Chemistry

Technology in Cancer Research & Treatment, 2022
Objective: Traditional chemical synthesis methods are cumbersome and inefficient. In this study, a novel antitumor molecule, 4-(4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)phenyl sulfurofluoridate (P19G1), was ...
Qianfei Cui PhD, Peng Song PhD, Tiancheng Ma PhD, Zefeng Wang PhD, Xiaojing Lu MS, Yongjia Shi MS, Fang Zhang PhD, Guoqiang Lin PhD, Jiajia Dong PhD, Jiange Zhang PhD   +9 more
doaj   +1 more source

DataSheet1_Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents.docx [PDF]

, 2022
Ligustrazine (TMP) is a natural pyrazine alkaloid extracted from the roots of Ligusticum Chuanxiong Hort, which has the potential as an antitumor agent.
Ning Zhang (23771), Tianjun Liu (1746298), Peipei Wei (6534719), Jiafu Hou (13146582), Jiawen Wang (350508), Fucheng Zhu (2313250), Ge Hong (2126827), Shitang Ma (13146579), Shijuan Liu (1802113), Baowei Lu (13146585)   +9 more
core   +1 more source

A rapid primary screening method for antitumor using the oomycete Pythium aphanidermatum. [PDF]

, 2018
Investigating bioactive components from microbial metabolites can provide potential source for drug discovery. There are a number of traditional antitumor compounds screening assays already described.
MELO, I. S. de, SANTOS, S. N.
core   +1 more source

Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

MedComm, 2021
Colorectal cancer (CRC) is one of the most common malignancies currently. Despite advances in drug development, the survival and response rates in CRC patients are still poor.
Xiang‐Peng Tan, Yan He, Yun‐Na Huang, Can‐Can Zheng, Jun‐Qi Li, Qin‐Wen Liu, Ming‐Liang He, Bin Li, Wen‐Wen Xu   +8 more
doaj   +1 more source

Radiosensitization in esophageal squamous cell carcinoma Effect of polo-like kinase 1 inhibition [PDF]

, 2017
Purpose This study examined the efficacy of polo-like kinase 1 (PLK1) inhibition on radiosensitivity in vitro and in vivo by a pharmacologic approach using the highly potent PLK1 inhibitor volasertib.
Chen, Jenny Ling-Yu;Chen, Jo-Pai;Huang, Yu-Sen;Tsai, Yuan-Chun;Tsai, Ming-Hsien;Jaw, Fu-Shan;Cheng, Jason Chia-Hsien;Kuo, Sung-Hsin;Shieh, Ming-Jium, 謝銘鈞;郭頌鑫;成佳憲;陳若白;黃昱森;趙福杉   +1 more
core   +1 more source