Results 61 to 70 of about 37,916 (265)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Application and Progress of Organoid-on-a-chip Platforms 
in Lung Cancer Diagnosis and Therapy

Chinese Journal of Lung Cancer
Lung cancer remains one of the most prevalent and lethal malignancies worldwide. The advancement of its precise diagnosis and therapeutic development urgently requires in vitro models that can highly recapitulate the pathophysiological characteristics of
Wuyang YUN, Xiaoyun ZHANG, Li XIAO
doaj   +1 more source

The identification of potent dual-target monopolar spindle 1 (MPS1) and histone deacetylase 8 (HDAC8) inhibitors through pharmacophore modeling, molecular docking, molecular dynamics simulations, and biological evaluation

Frontiers in Pharmacology
BackgroundOverexpression of monopolar spindle 1 (MPS1) and histone deacetylase 8 (HDAC8) is associated with the proliferation of liver cancer cells, so simultaneous inhibition of both MPS1 and HDAC8 could offer a promising therapeutic approach for the ...
Huilian Hua, Lixia Guan, Bo Pan, Junyi Gao, Yifei Geng, Miao-Miao Niu, Zhiqin Li, Jindong Li   +7 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Study on the sensitivity of primary glioma cell to chemotherapeutic agents in vitro

Chinese Journal of Contemporary Neurology and Neurosurgery, 2010
Objective To study the sensitivity of primary human glioma cell to chemotherapeutic agents in vitro in order to provide an experimental basis for clinical chemotherapy of glioma.
Ning WANG, Wei WANG, Ri⁃xiao YANG, Mao⁃de WANG, Tuo WANG, Wei CHEN, Qi LI   +6 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Targeting of focal adhesion kinase enhances the immunogenic cell death of PEGylated liposome doxorubicin to optimize therapeutic responses of immune checkpoint blockade

Journal of Experimental & Clinical Cancer Research
Backgrounds Immune checkpoint blockade (ICB) is widely considered to exert long-term treatment benefits by activating antitumor immunity. However, many cancer patients show poor clinical responses to ICB due in part to the lack of an immunogenic niche ...
Baoyuan Zhang, Ning Li, Jiaming Gao, Yuxi Zhao, Jun Jiang, Shuang Xie, Cuiping Zhang, Qingyu Zhang, Leo Liu, Zaiqi Wang, Dongmei Ji, Lingying Wu, Ruibao Ren   +12 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Avaliação das atividades antioxidante, antiinflamatória e antitumoral do extrato bruto hidro-etanólico e frações de Bidens pilosa L. (Asteraceae) [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.
Kviecinski, Maicon Roberto
core  

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties [PDF]

, 2015
This work was supported by National Institute of Mental Health grants: P30 MH075673-06 to BSS, CR, NJH and JCM; R01 MH096636 and R01 MH077542 to NJH (http://projectreporter.nih.gov/reporter.​cfm); and The Johns Hopkins Brain Science Institute to BSS ...
Justin C. McArthur (66539), Bandaru, Veera Venkata Ratnam, Graeme W. Rogers (744791), Yoo, Seung-Wan, Seung-Wan Yoo (744790), McArthur, Justin C., Justin C McArthur, Veera Venkata Ratnam Bandaru (193990), Haughey, Norman J., Marigo Stathis, Graeme W Rogers, Figuera-Losada, Mariana, Veera Venkata Ratnam Bandaru, Stathis, Marigo, Norman J Haughey, Slusher, Barbara S., Barbara S Slusher, Barbara S. Slusher (634276), Joelle M Dorskind, Nicholas J Westwood, Seung-Wan Yoo, Norman J. Haughey (193998), Mariana Figuera-Losada (744786), Marigo Stathis (744787), Camilo Rojas (744792), Ajit G. Thomas (744789), Westwood, Nicholas James, Rojas, Camilo, Nicholas J. Westwood (254891), Thomas, Ajit G., Rogers, Graeme Wayne, Mariana Figuera-Losada, Joelle M. Dorskind (744788), Ajit G Thomas, Dorskind, Joelle M., Camilo Rojas   +35 more
core   +1 more source