Results 21 to 30 of about 66,892 (264)

Discovery of a Novel Potent Antitumor Molecule, P19G1, by Erlotinib Derivative Libraries Synthesized by Modular Click-Chemistry

Technology in Cancer Research & Treatment, 2022
Objective: Traditional chemical synthesis methods are cumbersome and inefficient. In this study, a novel antitumor molecule, 4-(4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)phenyl sulfurofluoridate (P19G1), was ...
Qianfei Cui PhD, Peng Song PhD, Tiancheng Ma PhD, Zefeng Wang PhD, Xiaojing Lu MS, Yongjia Shi MS, Fang Zhang PhD, Guoqiang Lin PhD, Jiajia Dong PhD, Jiange Zhang PhD   +9 more
doaj   +1 more source

Caracterización del perfil de sensibilidad de un panel de líneas celulares para valoración de citotoxicidad in vitro.

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. La valoración de la citotoxicidad in vitro de líneas celulares derivadas de tumores humanos se emplea como bioensayo preliminar para el tamizaje de productos de origen natural con potencial actividad anticancerígena. Objetivo. Fortalecer el
Claudia Jhoana León, Sandra Milena Gómez, Sandra Johanna Morantes, Claudia Patricia Cordero, Fabio Ancízar Aristizábal   +4 more
doaj   +1 more source

DIMP53-1:A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties [PDF]

, 2017
The transcription factor p53 plays a crucial role in cancer development and dissemination, and thus, p53-targeted therapies are among the most encouraging anticancer strategies.
Baeriswyl, Burgess, Cordani, Gomes, Graves, Hong, Lee, Li, Lion, Maeda, Pal, Pereira, Powell, Qin, Reed, Soares, Soares, Soares, Spano, Tan, Vassilev, Vasudev, Wade, Weidner   +23 more
core   +2 more sources

Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

MedComm, 2021
Colorectal cancer (CRC) is one of the most common malignancies currently. Despite advances in drug development, the survival and response rates in CRC patients are still poor.
Xiang‐Peng Tan, Yan He, Yun‐Na Huang, Can‐Can Zheng, Jun‐Qi Li, Qin‐Wen Liu, Ming‐Liang He, Bin Li, Wen‐Wen Xu   +8 more
doaj   +1 more source

Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

Cell Death and Disease, 2023
Pancreatic cancer is a highly aggressive cancer, and is primarily treated with gemcitabine, with increasing resistance. SIRT6 as a member of sirtuin family plays important roles in lifespan and diverse diseases, such as cancer, diabetes, inflammation and
Nannan Song, Xian Guan, Siqi Zhang, Yanqing Wang, Xuekai Wang, Zhongxia Lu, Daochen Chong, Jennifer Yiyang Wang, Rilei Yu, Wengong Yu, Tao Jiang, Yuchao Gu   +11 more
doaj   +1 more source

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. [PDF]

, 2015
Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types.
Baday, Yiressy C, Bao, Ju, Guibao, Cristina, Lee, Ho-Jin, Li, Lin, Miller, Ami, Wu, Dianqing, Wu, Jibo, Zhang, Chi, Zheng, Jie J   +9 more
core   +2 more sources

Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization

Molecules, 2018
Some fluoroquinazolinones (A–H) were designed, synthesized and biologically evaluated for their antitumor activity against the two cell lines, MCF-7 and MDA-MBA-231.
Mohamed F. Zayed, Heba S. Rateb, Sahar Ahmed, Osama A. Khaled, Sabrin R. M. Ibrahim   +4 more
doaj   +1 more source

A high-throughput drug combination screen identifies an anti-glioma synergism between TH588 and PI3K inhibitors

Cancer Cell International, 2020
Background Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor. More than half of GBMs contain mutation(s) of PTEN/PI3K/AKT, making inhibitors targeting the PI3K pathway very attractive for clinical investigation ...
Zhen Chen, Chao Chen, Tingting Zhou, Chao Duan, Qianqian Wang, Xiaohui Zhou, Xia Zhang, Fangrong Wu, Yunfen Hua, Fan Lin   +9 more
doaj   +1 more source

Strain prioritization and genome mining for enediyne natural products [PDF]

, 2016
The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen, Christoph Rader, Dong Yang, Filip Van Nieuwerburgh, Hindra, Huiming Ge, Ivana Crnovčičć, Jeffrey D. Rudolf, Jeremy R. Lohman, Li-Xing Zhao, Qihui Teng, Tingting Huang, Xiangcheng Zhu, Xiaohui Yan, Xiuling Li, Yannick Gansemans, Yanwen Duan, Yi Jiang, Yong Huang   +18 more
core   +2 more sources

CRISPR/Cas9 screening identifies a kinetochore‐microtubule dependent mechanism for Aurora‐A inhibitor resistance in breast cancer

Cancer Communications, 2021
Background Overexpression of Aurora‐A (AURKA) is a feature of breast cancer and associates with adverse prognosis. The selective Aurora‐A inhibitor alisertib (MLN8237) has recently demonstrated promising antitumor responses as a single agent in various ...
Ailin Chen, Shijun Wen, Fang Liu, Zijian Zhang, Meiling Liu, Yuanzhong Wu, Bin He, Min Yan, Tiebang Kang, Eric W‐F Lam, Zifeng Wang, Quentin Liu   +11 more
doaj   +1 more source