Results 21 to 30 of about 120,380 (317)

Ammonia-induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis [PDF]

ACS Applied Materials & Interfaces Manuscript ID: am-2021-004953.R2, 2021
Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective therapeutic solutions for those diseases. Here we reported the development of a novel and robust nano-structured calcium
arxiv   +1 more source

Leveraging Interactions in Microfluidic Droplets for Enhanced Biotechnology Screens [PDF]

Current Opinion in Biotechnology, August 2023, Volume 82, 102966, 2023
Microfluidic droplet screens serve as an innovative platform for high-throughput biotechnology, enabling significant advancements in discovery, product optimization, and analysis. This review sheds light on the emerging trend of interaction assays in microfluidic droplets, underscoring the unique suitability of droplets for these applications ...
arxiv   +1 more source

Design and Validation of Experimental Setup for Cell Spheroid Radiofrequency-Induced Heating

Sensors, 2023
While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment
Ioannis Androulakis, Riccardo Ferrero, Rogier van Oossanen, Alessandra Manzin, Antonia G. Denkova, Kristina Djanashvili, Robin Nadar, Gerard C. van Rhoon   +7 more
doaj   +1 more source

Discovery of a Novel Potent Antitumor Molecule, P19G1, by Erlotinib Derivative Libraries Synthesized by Modular Click-Chemistry

Technology in Cancer Research & Treatment, 2022
Objective: Traditional chemical synthesis methods are cumbersome and inefficient. In this study, a novel antitumor molecule, 4-(4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)phenyl sulfurofluoridate (P19G1), was ...
Qianfei Cui PhD, Peng Song PhD, Tiancheng Ma PhD, Zefeng Wang PhD, Xiaojing Lu MS, Yongjia Shi MS, Fang Zhang PhD, Guoqiang Lin PhD, Jiajia Dong PhD, Jiange Zhang PhD   +9 more
doaj   +1 more source

Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3,4,5,6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential antitumor activity in vitro.
L. Racané, M. Cindrić, Ivo Zlatar, T. Kezele, A. Milić, K. Brajša, M. Hranjec   +6 more
semanticscholar   +1 more source

Caracterización del perfil de sensibilidad de un panel de líneas celulares para valoración de citotoxicidad in vitro.

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. La valoración de la citotoxicidad in vitro de líneas celulares derivadas de tumores humanos se emplea como bioensayo preliminar para el tamizaje de productos de origen natural con potencial actividad anticancerígena. Objetivo. Fortalecer el
Claudia Jhoana León, Sandra Milena Gómez, Sandra Johanna Morantes, Claudia Patricia Cordero, Fabio Ancízar Aristizábal   +4 more
doaj   +1 more source

Antitumor activity of an anti-CD98 antibody. [PDF]

, 2015
CD98 is expressed on several tissue types and specifically upregulated on fast-cycling cells undergoing clonal expansion. Various solid (e.g., nonsmall cell lung carcinoma) as well as hematological malignancies (e.g., acute myeloid leukemia) overexpress ...
Cairns, Belinda, Cantor, Joseph M, Chinn, Lawrence, Duey, Dana, Ginsberg, Mark H, H van der Horst, Edward, Hayes, Gregory M, Levashova, Zoia, Lippincott, John, Tran, Hoang, Velilla, Timothy, Zachwieja, Joseph   +11 more
core   +1 more source

Virtual screening for inhibitors of the human TSLP:TSLPR interaction [PDF]

, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis.
AA Bogan, AC Braisted, AJ Souers, C Ghirelli, D Sun, DR Hall, G Neudert, G Pérez-Hernández, GM Gauvreau, HH Loeffler, J Corren, J Felix, J Yin, JM Wang, K Lindorff-Larsen, K Verstraete, K Verstraete, L Deng, LS Park, M Guillot-Delost, M Noti, M Piazza Di, MJ Abraham, NS Redhu, O Trott, P Buchwald, P Chames, RL Rich, S Demehri, S Doerr, S Ulrich, SD Levin, SF Ziegler, T Clackson   +33 more
core   +2 more sources

Strain prioritization and genome mining for enediyne natural products [PDF]

, 2016
The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen, Christoph Rader, Dong Yang, Filip Van Nieuwerburgh, Hindra, Huiming Ge, Ivana Crnovčičć, Jeffrey D. Rudolf, Jeremy R. Lohman, Li-Xing Zhao, Qihui Teng, Tingting Huang, Xiangcheng Zhu, Xiaohui Yan, Xiuling Li, Yannick Gansemans, Yanwen Duan, Yi Jiang, Yong Huang   +18 more
core   +5 more sources

Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

MedComm, 2021
Colorectal cancer (CRC) is one of the most common malignancies currently. Despite advances in drug development, the survival and response rates in CRC patients are still poor.
Xiang‐Peng Tan, Yan He, Yun‐Na Huang, Can‐Can Zheng, Jun‐Qi Li, Qin‐Wen Liu, Ming‐Liang He, Bin Li, Wen‐Wen Xu   +8 more
doaj   +1 more source