Results 51 to 60 of about 120,380 (317)

Scalable lipid droplet microarray fabrication, validation, and screening [PDF]

arXiv, 2022
High throughput screening of small molecules and natural products is costly, requiring significant amounts of time, reagents, and operating space. Although microarrays have proven effective in the miniaturization of screening for certain biochemical assays, such as nucleic acid hybridization or antibody binding, they are not widely used for drug ...
arxiv  

A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]

, 2020
The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi, Demuynck, Robin, Efimova, Iuliia, Krysko, Dmitri, Lin, Abraham   +4 more
core   +1 more source

Uso de teste de químio-sensibilidade para escolha da quimioterapia adjuvante no câncer gástrico avançado

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Introduzir e familiarizar em nosso meio o uso do teste de químio-sensibilidade MTT avaliando a ação de agentes quimioterápicos sobre células tumorais de 30 doentes com câncer gástrico avançado.
Wilson Shinjiro Matsuzaki, Francisco César Martins Rodrigues, Carlos Alberto Malheiros, Fares Rahal   +3 more
doaj   +1 more source

Novel cyanine dye as competitive ligand for probing the drug–nucleic acid interactions

Біофізичний вісник, 2020
Background: During the past decades, increasing attention has been given to elucidating the molecular details of interactions between the pharmacological agents and nucleic acids since the drug–DNA complexation may lead to impairment of DNA replication ...
O. Zhytniakivska, U. Tarabara, A. Kurutos, A. Zabrudska, K. Vus, V. Trusova, G. Gorbenko, T. Deligeorgiev   +7 more
doaj   +1 more source

Natural product diversity of actinobacteria in the Atacama Desert [PDF]

, 2018
Natural Product diversityPeer reviewedPublisher ...
Ebel, Rainer, Jaspars, Marcel, Rateb, Mostafa E.   +2 more
core   +3 more sources

A promising approach for the real-time quantification of cytosolic protein-protein interactions in living cells [PDF]

, 2020
In recent years, cell-based assays have been frequently used in molecular interaction analysis. Cell-based assays complement traditional biochemical and biophysical methods, as they allow for molecular interaction analysis, mode of action studies and even drug screening processes to be performed under physiologically relevant conditions.
arxiv   +1 more source

Small molecule induced reactivation of mutant p53 in cancer cells [PDF]

, 2013
The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams, Alan R. Fersht, Andreas C. Joerger, Boeckler, Brown, Bullock, Bullock, Chipuk, Chuckowree, Cook, Dearth, Di Como, Emsley, Endo, Foster, Gannon, Green, Hengartner, Irina S. Chuckowree, Jahangir Amin, Joerger, Joerger, Joerger, Joerger, John Spencer, Johnson, Kaar, Kabsch, Kojima, Kojima, Lambert, Lane, Legros, Leslie, Liu, Newhouse, Oda, Petitjean, Rainer Wilcken, Rippin, Speidel, Spencer, Spencer, Spencer, Spencer, Spencer, Taylor, Van Maerken, Vassilev, Villunger, Vousden, Walerych, Wang, Wattel, Wilcken, Wilcken, Wolter, Xiangrui Liu, Yu   +58 more
core   +2 more sources

A generative recommender system with GMM prior for cancer drug generation and sensitivity prediction [PDF]

arXiv, 2022
Recent emergence of high-throughput drug screening assays sparkled an intensive development of machine learning methods, including models for prediction of sensitivity of cancer cell lines to anti-cancer drugs, as well as methods for generation of potential drug candidates.
arxiv  

Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity

ACS Omega
MCL-1, an antiapoptotic member of the BCL-2 family, is dysregulated and overexpressed in various tumors. In tumors with MCL-1 overexpression, selective inhibitors of MCL-1 are expected to overcome the drug resistance caused by BCL-2 inhibitors currently ...
Qineng Gong, Chunpu Li, Haojie Wang, Jinrui Cao, Zuo Li, Mi Zhou, Yan Li, Yong Chu, Hong Liu, Renxiao Wang   +9 more
semanticscholar   +1 more source

NEW BUTYROLACTONE FROM A MARINE-DERIVED FUNGUS ASPERGILLUS SP [PDF]

, 2011
Indexación: Web of Science; ScieloFour compounds that belong to two structure types, namely dibenzylbutyrolactone and sesterterpenoids, were obtained from the extract of the strain Aspergillus sp. (2P-22), isolated from a marine sponge, Cliona chilensis.
ACEVEDO, LAURA, CHAMY, MARÍA CRISTINA, ORALLO, FRANCISCO, ROVIROSA, JUANA, SAN-MARTÍN, AURELIO, VACA, INMACULADA, VERGARA, KAREN, VIÑA, DOLORES   +7 more
core   +1 more source