Results 61 to 70 of about 120,380 (317)

Assessing individual head and neck squamous cell carcinoma patient response to therapy through integration of functional and genomic data

Scientific Reports
Even though head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide, there are only two PD-1 targeted immunotherapies (pembrolizumab and nivolumab) and one tumor intrinsic EGFR targeted therapy (cetuximab) that are FDA ...
Daniel Bottomly, Chase Mathieson, Myles Vigoda, Sophia Jeng, Nathaniel Evans, Ashley Anderson, Aurora Blucher, Aletha Lesch, Christina Zheng, Ted Laderas, James Jacobs, Molly Kulesz-Martin, Shannon McWeeney   +12 more
doaj   +1 more source

Systematic screening of bryophytes for antitumor agents [PDF]

, 1992
References are made to cytotoxic and/or antitumor compounds that have been isolated - ansamitocin P-3 from Claopodium crispifolium (Hook.) Ren. & Card.
Cassady, John M., Kingston, David G. I., Spjut, Richard W.   +2 more
core  

Intravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study. [PDF]

, 2017
Purpose Many patients with high-risk non-muscle-invasive bladder cancer (NMIBC) are either refractory to bacillus Calmette-Guerin (BCG) treatment or may experience disease relapse.
Bivalacqua, Trinity J, Boorjian, Stephen A, Boyd, Alan, Canter, Daniel J, Dinney, Colin P N, Downs, Tracy M, Gomella, Leonard G, Gregory, Gillian, Grubb, Robert L, Inman, Brant A, Kamat, Ashish M, Karsh, Lawrence I, Krupski, Tracey L, Lerner, Seth P, Lotan, Yair, Milowsky, Matthew I, Ogan, Kenneth, Parker, Nigel R, Sawutz, David G, Shore, Neal D, Svatek, Robert S, Treasure, F Peter, Woods, Michael E, Yla-Herttuala, Seppo   +23 more
core   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Three-dimensional cell cultures as a new tool in drug discovery [PDF]

, 2016
Background and purpose: Producing of reliable information about pharmacological activity of new chemical entities is essential in early stages of drug discovery and development. There is a continuous need for improvement of existing in vitro technologies,
Dubravko Jelić, Ivo Zlatar, Karmen Brajša, Marija Trzun   +3 more
core   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics [PDF]

arXiv, 2020
The recent global pandemic of Coronavirus Disease 2019 (COVID-19) caused by the new coronavirus SARS-CoV-2 presents an urgent need for new therapeutic candidates. Many efforts have been devoted to screening existing drug libraries with the hope to repurpose approved drugs as potential treatments for COVID-19. However, the antiviral mechanisms of action
arxiv  

Bioguided Fraction and Isolation of the Antitumor Components from Phyllanthus niruri L.

BioMed Research International, 2016
Phyllanthus niruri L., a well-known medicinal plant, has been used as a folk antitumor remedy in the worldwide scale. However, the antitumor components in P. niruri have not been reported. In order to verify the antitumor components of P.
Zhizhong Zheng, Liang-hua Chen, Shaosong Liu, Yuan Deng, G. Zheng, Yue Gu, Y. Ming   +6 more
semanticscholar   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

A high-throughput assay for screening natural products that boost NK cell-mediated killing of cancer cells

Pharmaceutical Biology, 2020
Context Natural killer (NK) cells can eliminate malignant cells and play a vital role in immunosurveillance. Administration of natural compounds represents a promising approach for antitumor immunotherapy, which may enhance the NK cell activity via ...
Zihang Xu, Xiaowen Zhu, Lin Su, Chunpu Zou, Xiao Chen, Yifei Hou, Chenyuan Gong, Wanyi Ng, Zhongya Ni, Lixin Wang, Xuewei Yan, Yangzhuangzhuang Zhu, Xiaoning Jiao, Chao Yao, Shiguo Zhu   +14 more
doaj   +1 more source