Anthelmintic drug discovery: target identification, screening methods and the role of open science [PDF]
Beilstein Journal of Organic Chemistry, 2020 Helminths, including cestodes, nematodes and trematodes, are a huge global health burden, infecting hundreds of millions of people. In many cases, existing drugs such as benzimidazoles, diethylcarbamazine, ivermectin and praziquantel are insufficiently ...
Frederick A. Partridge +7 more
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Statistical Analysis of High Content Screening Data [PDF]
, 2009 High throughput screening experiments are typically used within the pharmaceutical industry for the identification and evaluation of candidate drugs. Using a high throughput screen with automated imaging platform allows a large number of compounds to be ...
Jacques, Richard
core +6 more sources
In vitro screening of selected medicinal plants against Schistosoma mansoni larvae [PDF]
, 2011 Schistosomiasis, caused by various members of the trematode flatworms (Schistosoma species) is the second most important parasitic disease next to malaria.
Tasdemir, Deniz +11 more
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Complementary approaches to target human respiratory syncytial virus using small molecule ligands [PDF]
, 2012 In the current project, situated at the interface of chemistry and virology, complementary drug discovery approaches (high-throughput screening and structurebased drug design) have been exploited in order to discover novel small molecule inhibitors of ...
Lardeau, Charles-Hugues Claude Jean
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Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays [PDF]
, 2015 Schistosomiasis is responsible for a tremendous public health burden, yet only a single drug, praziquantel, is available. New antischistosomal treatments should therefore be developed. The accuracy, speed and objectivity of in vitro drug screening depend
Gordana Panic +7 more
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Advances in the application of high-throughput microfluidic platforms in precise diagnosis and treatment of tumors [PDF]
精准医学杂志Although the treatment of malignant tumors has entered an era of comprehensive therapy integrating chemotherapy, targeted therapy, immunotherapy, and other modalities, there is still a significant gap from individualized precise treatment.
DOU Liliang, CHU Jiahui, LIU Lian
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Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening
Sensors, 2016 Microfluidics-based drug-screening systems have enabled efficient and high-throughput drug screening, but their routine uses in ordinary labs are limited due to the complexity involved in device fabrication and system setup.
Zhuofa Chen +6 more
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Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]
, 2010 BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D +7 more
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A fluorescence-based assay for Trichomonas vaginalis drug screening
Parasites & Vectors, 2023 Abstract Background The emergence and spread of drug resistance in Trichomonas vaginalis parasites has become an important concern in trichomoniasis treatment. Fast and reliable growth assessment is critical for validating in vitro drug susceptibility and high-throughput screening of newly developed drugs.
Qianqian Chen +5 more
openaire +3 more sources
Biomédica: revista del Instituto Nacional de Salud, 2006 Introducción. La valoración de la citotoxicidad in vitro de líneas celulares derivadas de tumores humanos se emplea como bioensayo preliminar para el tamizaje de productos de origen natural con potencial actividad anticancerígena. Objetivo. Fortalecer el
Claudia Jhoana León +4 more
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