Recent advances in screening of enzymes inhibitors based on capillary electrophoresis
Journal of Pharmaceutical Analysis, 2018 Capillary electrophoresis with many advantages plays an important role in pharmaceutical analysis and drug screening. This review gives an overview on the recent advances in the developments and applications of capillary electrophoresis in the field of ...
Mengxia Cheng, Zilin Chen
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Cheburator software for automatically calculating drug inhibitory concentrations from in vitro screening assays. [PDF]
PLoS ONE, 2014 In the process of new cancer drug development, as the first step of their assessment, their activities are usually studied in vitro against a panel of cancer cell lines.
Dmitry Nevozhay
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Primary and Secondary Drug Screening Assays for Friedreich Ataxia [PDF]
SLAS Discovery, 2012 Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardiodegenerative disorder for which there are no proven effective treatments. FRDA is caused by decreased expression and/or function of the protein frataxin. Frataxin chaperones iron in the mitochondrial matrix for the assembly of iron-sulfur clusters (ISCs), which are prosthetic groups ...
M Grazia, Cotticelli +13 more
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Novel network pharmacology methods for drug mechanism of action identification, pre-clinical drug screening and drug repositioning [PDF]
, 2011 The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Here we present two methodology innovations on network pharmacology modeling.
Jianghui Xiong
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Developing pharmacogenetic screening methods for an emergent country: Vietnam
World Allergy Organization Journal, 2019 Background: The finding of strong associations between certain human leukocyte antigen (HLA) genotypes and the development of severe cutaneous adverse drug reactions (SCARs), [for example, HLA-B*57:01 and abacavir (ABC), HLA-B*15:02 and carbamazepine ...
Dinh Van Nguyen +3 more
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Preclinical therapeutics ex ovo quail eggs as a biomimetic automation-ready xenograft platform
Scientific Reports, 2021 Preclinical cancer research ranges from in vitro studies that are inexpensive and not necessarily reflective of the tumor microenvironment to mouse studies that are better models but prohibitively expensive at scale. Chorioallantoic membrane (CAM) assays
Samuel V. Rasmussen +6 more
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Predicting Binding from Screening Assays with Transformer Network Embeddings [PDF]
, 2020 Cheminformatics aims to assist in chemistry applications that depend on molecular interactions, structural characteristics, and functional properties.
Paul, Morris +3 more
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Novel Doxorubicin Derivatives: Synthesis and Cytotoxicity Study in 2D and 3D in Vitro Models [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Multidrug resistance (MDR) of tumors to chemotherapeutics often leads to failure of cancer treatment. The aim of the study was to prepare novel MDR-overcoming chemotherapeutics based on doxorubicin (DOX) derivatives and to evaluate their ...
Roman Akasov +10 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations
Pediatric Blood &Cancer, EarlyView.ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan +18 more
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