Results 21 to 30 of about 3,507,735 (293)

Anticancer drug screening of natural products: In vitro cytotoxicity assays, techniques, and challenges

Asian Pacific Journal of Tropical Biomedicine, 2022
Natural products include several diverse compounds that have been found to be effective against cancer. Discovering anticancer compounds in nature is a multistep and complex process that requires pre-clinical and clinical studies.
Agustina Setiawati, Damiana Sapta Candrasari, F D. Erika Setyajati, Vincentia Krisnina Prasetyo, Dewi Setyaningsih, Yustina Sri Hartini   +5 more
doaj   +1 more source

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity. [PDF]

PLoS Neglected Tropical Diseases, 2015
Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arsenal of drugs available for treatment. The existing drugs have significant deficiencies so there is an urgent need for new and improved drugs. In the human
Andrea Nühs, Manu De Rycker, Sujatha Manthri, Eamon Comer, Christina A Scherer, Stuart L Schreiber, Jean-Robert Ioset, David W Gray   +7 more
doaj   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Gilbert, Ian H., Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E   +46 more
core   +2 more sources

Application of RNAi to Genomic Drug Target Validation in Schistosomes. [PDF]

, 2015
Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to the development of improved whole organism screens, the success of RNA interference (RNAi) in ...
Bickle, Quentin D, Bickle, Quentin D., Carruthers, Ian M, Gilbert, Ian H, Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Jérémy Besnard (741480), Hopkins, Andrew L, Gilbert, Ian H., Guidi, Alessandra, Quentin D. Bickle (146947), Ian H. Gilbert (146934), Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Ross A Paveley, Ian M Carruthers, Carruthers, Ian M., Jérémy Besnard, Quentin D Bickle, Paveley, Ross A, Besnard, Jérémy, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Hopkins, Andrew L., Andrew L Hopkins, Ian M. Carruthers (741479)   +29 more
core   +1 more source

Protein Reporter Bioassay Systems for the Phenotypic Screening of Candidate Drugs: A Mouse Platform for Anti-Aging Drug Screening

Sensors, 2012
Recent drug discovery efforts have utilized high throughput screening (HTS) of large chemical libraries to identify compounds that modify the activity of discrete molecular targets.
Isao Shimokawa, Ryoichi Mori, Tomoshi Tsuchiya, Takuya Chiba   +3 more
doaj   +1 more source

Role of in vitro two-dimensional (2D) and three-dimensional (3D) cell culture systems for ADME-Tox screening in drug discovery and development: a comprehensive review

ADMET and DMPK, 2022
Drug discovery and development have become a very time-consuming and expensive process. Preclinical animal models have become the gold standard for studying drug pharmacokinetic and toxicity parameters.
Venkatesh Chunduri, Srinivas Maddi
doaj   +1 more source

The role of the Interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident [PDF]

, 2011
In 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker.
Abubakar, Ibrahim, Nikolayevskyy, V, Elizabeth Davies, Abubakar, I, Flanagan, P, Paul Kelly, Davies Elizabeth, Abubakar Ibrahim, O'Connor, K, Vladislav Nikolayevskyy, Davies, E, Nikolayevskyy Vladislav, Bradshaw Louise, Flanagan, Peter, Davies, Elizabeth, Devine, M, Devine, Michael, Kevin O'Connor, Peter Flanagan, Drobniewski, F, Kelly Paul, Nikolayevskyy, Vladislav, Drobniewski, Francis, Ibrahim Abubakar, O'Connor Kevin, O'Connor, Kevin, Louise Bradshaw, Francis Drobniewski, Bradshaw, L, Bradshaw, Louise, Kelly, Paul, Michael Devine, Flanagan Peter, Devine Michael, Kelly, P, Drobniewski Francis   +35 more
core   +2 more sources

Luciferase complementation based-detection of G-protein-coupled receptor activity

BioTechniques, 2018
Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects.
Hideaki Yano, Ning Sheng Cai, Jonathan A Javitch, Sergi Ferré   +3 more
doaj   +1 more source

Ex Vivo Drug Screening Informed Targeted Therapy for Metastatic Parotid Squamous Cell Carcinoma

Frontiers in Oncology, 2021
The purpose of ex vivo drug screening in the context of precision oncology is to serve as a functional diagnostic method for therapy efficacy modeling directly on patient-derived tumor cells.
Noora Nykänen, Rami Mäkelä, Antti Arjonen, Ville Härmä, Ville Härmä, Laura Lewandowski, Eileen Snowden, Rainer Blaesius, Ismo Jantunen, Teijo Kuopio, Teijo Kuopio, Juha Kononen, Juha K. Rantala, Juha K. Rantala   +13 more
doaj   +1 more source

Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis. [PDF]

, 2011
The high burden of tuberculosis (TB) among patients accessing antiretroviral treatment (ART) services in resource-limited settings is a major cause of morbidity and mortality and is associated with nosocomial transmission risk.
Lawn, Stephen D, Robin Wood, Wood, Robin, Stephen D. Lawn   +3 more
core   +1 more source