Results 91 to 100 of about 634,895 (315)
Drug design principles from electric field calculations: understanding SARS-CoV-2 main protease interaction with X77 non-covalent inhibitor [PDF]
arXiv, 2020 Fast and effective drug discovery processes rely on rational drug design to circumvent the tedious and expensive trial and error approach. However, accurate predictions of new remedies, which are often enzyme inhibitors, require a clear understanding of the nature and function of the key players governing the interaction between the drug candidate and ...
arxiv
Molecular Oncology, EarlyView.Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric +11 more
wiley +1 more source
Dual-trigger release of berberine chloride from the Gelatin/Perfluorohexane core-shell structure [PDF]
Background: The development of smart nanocarriers that enable controlled drug release in response to internal and external triggers is an emerging approach for targeted therapy. This study focused on designing pH-sensitive, ultrasound-responsive gelatin/perfluorohexane (PFH) nanodroplets loaded with berberine chloride as a model drug.
arxiv +1 more source
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source
Chemical Characterisations of Drug Stability
, 2001 The objective of the initial stages of this project was to develop a method for the separation of morphine sulphate and haloperidol using high performance liquid chromatography (HPLC). The HPLC methods were then validated. The validation parameters investigated were: accuracy, precision, linearity, specificity, system suitability, robustness, range ...
openaire +3 more sources
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Glycopeptide antibiotic drug stability in aqueous solution. [PDF]
AAPS Open, 2022 Jakaria SM, Budil DE, Murtagh J.
europepmc +1 more source
Molecular Dynamics Studies on HIV-1 Protease: Drug Resistance and Folding Pathways [PDF]
arXiv, 2001 Drug resistance to HIV-1 Protease involves accumulation of multiple mutations in the protein. Here we investigate the role of these mutations by using molecular dynamics simulations which exploit the influence of the native-state topology in the folding process.
arxiv
Technical Drug Studies: II. On The Stability of Spirit of Nitrous Ether* [PDF]
, 1916 Lyman F. Kebler +2 more
openalex +1 more source