Results 91 to 100 of about 8,056,631 (393)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release [PDF]

, 2018
In this study, the encapsulation of curcumin (Cur) in “drug-in-cyclodextrin-in-liposomes (DCL)” by following the double-loading technique (DL) was proposed, giving rise to DCL–DL.
Fernández Romero, Ana María, González Rodríguez, María Luisa, Maestrelli, Francesca, Mura, Paola Angela, Rabasco Álvarez, Antonio María   +4 more
core   +2 more sources

Use of Micellar Liquid Chromatography to Determine Mebendazole in Dairy Products and Breeding Waste from Bovine Animals [PDF]

, 2020
Mebendazole is an anthelmintic drug used in cattle production. However, residues may occur in produced food and in excretions, jeopardizing population health.
Albiol Chiva, Jaume, Bose, Devasish, Durgbanshi, Abhilasha, Esteve-Romero, Josep, García Ferrer, Daniel, Mishra, Pooja, Pawar, Rajendra-Prasad, Peris Vicente, Juan   +7 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Compatibility and stability of hyoscine n-butyl bromide and furosemide admixtures for use in palliative care [PDF]

, 2015
In order to avoid separate injections, admixtures of drugs are frequently used in palliative care settings. There are different factors that can influence the compatibility and stability of the mixture: drug type, concentration, solvent, container ...
Bosch-Ojeda, Catalina, Espinosa Bosch, M, Sanchez-Rojas, Maria Fuensanta   +2 more
core  

Organizadores e cortadores de comprimidos: riscos e restrições ao uso Organizadores y cortadores de comprimidos: riesgos y restricciones del uso Pill organizers and pill cutters: risks and limitations

Revista de Saúde Pública, 2013
Com base em análise documental, foram discutidas e problematizadas as limitações associadas à utilização de organizadores e cortadores de comprimidos, como questão de saúde pública. Os organizadores destinados ao armazenamento e transporte de comprimidos
Caroline Ribeiro de Borja-Oliveira
doaj  

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability

Pharmaceutics, 2018
Many approaches have been developed over time to overcome the bioavailability limitations of poorly soluble drugs. With the advances in nanotechnology in recent decades, science and industry have been approaching this issue through the formulation of ...
M. Gigliobianco, Cristina Casadidio, R. Censi, P. Di Martino   +3 more
semanticscholar   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Drug–Phospholipid Co-Amorphous Formulations: The Role of Preparation Methods and Phospholipid Selection

Pharmaceutics
Background/Objectives: This study aims to broaden the knowledge on co-amorphous phospholipid systems (CAPSs) by exploring the formation of CAPSs with a broader range of poorly water-soluble drugs, celecoxib (CCX), furosemide (FUR), nilotinib (NIL), and ...
Keyoomars Khorami, Sam Darestani Farahani, Anette Müllertz, Thomas Rades   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source