Results 41 to 50 of about 8,084,609 (393)
Science Advances, 2020 Trisulfide bond enhances the stability and GSH sensitivity of doxorubicin dimeric prodrug nanoassemblies. Rational design of nanoparticulate drug delivery systems (nano-DDS) for efficient cancer therapy is still a challenge, restricted by poor drug ...
Yinxian Yang +12 more
semanticscholar +1 more source
Molecules, 2022 In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low ...
Giuseppina Ioele +6 more
doaj +1 more source
Stability of extemporaneously prepared ophthalmic solutions for mydriasis [PDF]
, 2018 Purpose Results of an evaluation of the physical and chemical stability of extemporaneously prepared adult and pediatric ophthalmic solutions containing combinations of phenylephrine, tropicamide, and cyclopentolate are reported.
Camp, Nicole A. +4 more
core +2 more sources
Drug stability testing and formulation strategies
Pharmaceutical development and technology (Print), 2018 Drug stability is a crucial quality attribute determining not only the efficacy of the drug products but also the safety of patients.
Zimei Wu
semanticscholar +1 more source
Molecular Dynamics Studies on HIV-1 Protease: Drug Resistance and Folding Pathways [PDF]
, 2001 Drug resistance to HIV-1 Protease involves accumulation of multiple mutations in the protein. Here we investigate the role of these mutations by using molecular dynamics simulations which exploit the influence of the native-state topology in the folding ...
Carloni, Paolo +3 more
core +2 more sources
Drug Development and Industrial Pharmacy, 2018 The aim of the present research is to show that the methodology of Design of Experiments can be applied to stability data evaluation, as they can be seen as multi-factor and multi-level experimental designs.
N. Jordan +4 more
semanticscholar +1 more source
Crystals, 2023 Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bending test ...
Aleksandr S. Dubok, Denis A. Rychkov
doaj +1 more source
Curcumin-loaded zeolite as anticancer drug carrier: Effect of curcumin adsorption on zeolite structure [PDF]
, 2020 In this work we used a combination of different techniques to investigate the adsorption properties of curcumin by zeolite type A for potential use as an anticancer drug carrier.
Ahali Abadeh, Z. +3 more
core +1 more source
EVALUATION OF THE STABILITY OF VIGABATRIN IN HOSPITALAR EXTEMPORANEOUS FORMULATIONS
Drug Analytical Research, 2019 The aim of this study was to analyze the chemical stability of the anticonvulsant vigabatrin extemporaneous formulation from tablets in storage conditions of different temperatures and types of packaging used.
Marcio Vinicius Ayres +4 more
doaj +1 more source
Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
Pharmaceutics, 2021 Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher.
Laura E. McCoubrey +5 more
doaj +1 more source