Results 41 to 50 of about 7,797,679 (378)

Stability investigation of total parenteral nutrition admixture prepared in a hospital pharmacy [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. In the cases when nutrition of patients can not be orally nor enterally performed, parenteral nutrition is a method of the therapy that provides more successful and rapid recovery. In that way, hospitalization can be significantly shorter,
Mirković Dušica, Antunović Mirjana, Putić Vesna, Aleksić Dragana   +3 more
doaj   +1 more source

Stability of peptide drugs in the colon

European Journal of Pharmaceutical Sciences, 2015
This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and goserelin) in a model of the large intestine using mixed ...
Abdul Basit, Shinichiro Tajiri, Jie Wang, Vipul Yadav, Alice L Smart   +4 more
openaire   +3 more sources

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S, Chester, KA, Chudasama, V, Maruani, A, Miranda, E, Smith, ME   +5 more
core   +1 more source

Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease

Pharmaceutics, 2022
Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have been approved for treatment of ulcerative colitis with several other JAK inhibitors in late-stage clinical trials for inflammatory bowel disease (IBD).
Vipul Yadav, Aileen House, Silvia Matiz, Laura E. McCoubrey, Kimberly A. Bettano, Leena Bhave, Meiyao Wang, Peter Fan, Siqun Zhou, Janice D. Woodhouse, Eirini Poimenidou, Liu Dou, Abdul W. Basit, Lily Y. Moy, Robert Saklatvala, Laxminarayan G. Hegde, Hongshi Yu   +16 more
doaj   +1 more source

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. [PDF]

, 2011
Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
Ashley, Carlee E, Brinker, C Jeffrey, Brown, Page A, Carnes, Eric C, Carroll, Nick J, Carter, Mark B, Chackerian, Bryce, Dunphy, Darren R, Durfee, Paul N, Evans, Deborah G, Hanna, Tracey N, Jiang, Xingmao, Liu, Juewen, Padilla, David, Parikh, Atul N, Peabody, David S, Petsev, Dimiter N, Phillips, Brandy, Phillips, Genevieve K, Wharton, Walker, Willman, Cheryl L   +20 more
core   +2 more sources

An Approach to Drug Stability Studies and Shelf-life Determination

Archives of Current Research International, 2019
The main objective of carrying out stability studies of the drug product is to establish shelf life of drug during storage. Stability of drug is defined as “The capability of a particular formulation in a specific container/closed system, to remain ...
Ekta Tembhare, K. R. Gupta, M. Umekar
semanticscholar   +1 more source

Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Science Advances, 2020
Trisulfide bond enhances the stability and GSH sensitivity of doxorubicin dimeric prodrug nanoassemblies. Rational design of nanoparticulate drug delivery systems (nano-DDS) for efficient cancer therapy is still a challenge, restricted by poor drug ...
Yinxian Yang, Bingjun Sun, Shiyi Zuo, Ximu Li, Shuang Zhou, Lingxiao Li, C. Luo, Hongzhuo Liu, M. Cheng, Yongjun Wang, Shujun Wang, Zhonggui He, Jin Sun   +12 more
semanticscholar   +1 more source

Applying the methodology of Design of Experiments to stability studies: a Partial Least Squares approach for evaluation of drug stability

Drug Development and Industrial Pharmacy, 2018
The aim of the present research is to show that the methodology of Design of Experiments can be applied to stability data evaluation, as they can be seen as multi-factor and multi-level experimental designs.
N. Jordan, J. Zakrajšek, Simona Bohanec, R. Roškar, I. Grabnar   +4 more
semanticscholar   +1 more source

Ocular Drug Delivery: a Comprehensive Review

AAPS PharmSciTech, 2023
The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration is an interest of scientists for many decades. Their difficult mission is to
Sadek Ahmed, M. Amin, S. Sayed
semanticscholar   +1 more source

Challenges of Colistin Use in ICU and Therapeutic Drug Monitoring: A Literature Review

Antibiotics, 2023
The emerging resistance of Gram-negative bacteria is a growing problem worldwide. Together with the financial cost, limited efficacy, and local unavailability of newer antibiotics or their combinations, it has led to the reintroduction of colistin as a ...
Jitka Rychlíčková, Vendula Kubíčková, Pavel Suk, Karel Urbánek   +3 more
doaj   +1 more source