Results 51 to 60 of about 8,084,609 (393)

The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes. [PDF]

, 2015
A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been developed to minimize the severe side effects of the poorly water-soluble anticancer drug paclitaxel (PTX) for clinical use.
Chen, R, Chen, YZ, Gao, F, Lou, KY, Wang, Y, Ye, YJ   +5 more
core   +2 more sources

Stability investigation of total parenteral nutrition admixture prepared in a hospital pharmacy [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. In the cases when nutrition of patients can not be orally nor enterally performed, parenteral nutrition is a method of the therapy that provides more successful and rapid recovery. In that way, hospitalization can be significantly shorter,
Mirković Dušica, Antunović Mirjana, Putić Vesna, Aleksić Dragana   +3 more
doaj   +1 more source

Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules [PDF]

, 2017
G-quadruplexes are nucleic acids structures stabilized by physiological concentration of potassium ions. Because low stability G-quadruplexes are hardly detectable by mass spectrometry, we optimized solvent conditions: isopropanol in a triethylamine ...
Scalabrin, Matteo, Palumbo, Manlio, Richter, Sara N.   +2 more
core   +1 more source

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds [PDF]

, 2010
RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Alibu, Vincent P., Barrett, Michael P., Gilbert, Ian H., Norval, Suzanne, Read, Kevin D., Ruda, Gian Filippo, Wong, Pui Ee   +6 more
core   +4 more sources

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

Molecules
The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses.
Iwona Rykowska, Ola Michałkiewicz, Iwona Nowak, Rafał Nowak   +3 more
doaj   +1 more source

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications
The Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understanding of the cellular
Róbert Zach, Michael Annis, Sandra M. Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Megan Meredith, Kay Osborn, Nisha Peter, William Pearce, Jessica Booth, Mohan Rajasekaran, Samantha Dias, Lily Coleman-Evans, William R. Foster, Jon A. Harper, Alex D. Herbert, Catherine Tighe, Tristan Reuillon, Ryan West, Oliver Busby, Kamila Burdova, Damien Crepin, Sergi Ortoll, Kulthida Vaeteewoottacharn, Donniphat Dejsuphong, John Spencer, Hitesh Patel, Darren Le Grand, Thomas A. Hunt, David M. Andrews, Hiroyuki Yamano, Pedro R. Cutillas, Antony W. Oliver, Simon E. Ward, Helfrid Hochegger   +34 more
doaj   +1 more source

The Effectiveness of Intravenous Admixture Training in a Private Hospital in Surabaya [PDF]

, 2012
In this hospital, the nurses face intravenous (iv) admixture problems in preparing and delivering iv injection and/or infusion to patients due to their limited background knowledge of drug stability and incompatibility.
Herawati, Fauna
core  

Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release [PDF]

, 2019
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed with potential therapeutic effects on inflammatory bowel diseases (IBD), such as ...
Benito Hernández, Elena María, Díaz Blanco, Manuel Jesús, Galbis Fuster, Elsa, Iglesias, N., Lucas Rodríguez, Ricardo, Paz Báñez, María Violante de   +5 more
core   +2 more sources

Control of protein stability by post-translational modifications

Nature Communications, 2023
Post-translational modifications (PTMs) can occur on specific amino acids localized within regulatory domains of target proteins, which control a protein’s stability.
Ji Min Lee, Henrik M. Hammarén, M. Savitski, S. H. Baek   +3 more
semanticscholar   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source