Results 51 to 60 of about 8,056,631 (393)

Biochemical Stability and Microbial Control of Reconstituted DaxibotulinumtoxinA-lanm for Injection

Toxins, 2023
DaxibotulinumtoxinA-lanm for injection (DAXI) is a unique US Food and Drug Administration-approved product comprising daxibotulinumtoxinA and a stabilizing excipient peptide (RTP004).
Kimberlee Ellis, Thai Thach, Conor J. Gallagher   +2 more
doaj   +1 more source

Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization [PDF]

, 2017
En route towards improved delivery systems for targeted chemotherapy, we propose a straightforward approach for the hydrophobic modification of the acrylamide N-(2-Hydroxyethyl) acrylamide (HEAm).
De Geest, Bruno, Hennink, Wim E, Kasmi, Sabah, Louage, Benoit, Nuhn, Lutz, Van Herck, Simon, van Steenbergen, Mies J, Verstraete, Glenn, Vervaet, Chris   +8 more
core   +1 more source

Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota

Pharmaceutics, 2021
Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher.
Laura E. McCoubrey, Stavriani Thomaidou, Moe Elbadawi, Simon Gaisford, Mine Orlu, Abdul W. Basit   +5 more
doaj   +1 more source

Long-Term Amorphous Drug Stability Predictions Using Easily Calculated, Predicted, and Measured Parameters.

Molecular Pharmaceutics, 2015
The purpose of this study was to develop a predictive model of the amorphous stability of drugs with particular relevance for poorly water-soluble compounds.
Katarzyna Nurzyńska, J. Booth, C. Roberts, J. McCabe, I. Dryden, P. Fischer   +5 more
semanticscholar   +1 more source

Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release [PDF]

, 2019
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed with potential therapeutic effects on inflammatory bowel diseases (IBD), such as ...
Benito Hernández, Elena María, Díaz Blanco, Manuel Jesús, Galbis Fuster, Elsa, Iglesias, N., Lucas Rodríguez, Ricardo, Paz Báñez, María Violante de   +5 more
core   +2 more sources

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications
The Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understanding of the cellular
Róbert Zach, Michael Annis, Sandra M. Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Megan Meredith, Kay Osborn, Nisha Peter, William Pearce, Jessica Booth, Mohan Rajasekaran, Samantha Dias, Lily Coleman-Evans, William R. Foster, Jon A. Harper, Alex D. Herbert, Catherine Tighe, Tristan Reuillon, Ryan West, Oliver Busby, Kamila Burdova, Damien Crepin, Sergi Ortoll, Kulthida Vaeteewoottacharn, Donniphat Dejsuphong, John Spencer, Hitesh Patel, Darren Le Grand, Thomas A. Hunt, David M. Andrews, Hiroyuki Yamano, Pedro R. Cutillas, Antony W. Oliver, Simon E. Ward, Helfrid Hochegger   +34 more
doaj   +1 more source

Control of protein stability by post-translational modifications

Nature Communications, 2023
Post-translational modifications (PTMs) can occur on specific amino acids localized within regulatory domains of target proteins, which control a protein’s stability.
Ji Min Lee, Henrik M. Hammarén, M. Savitski, S. H. Baek   +3 more
semanticscholar   +1 more source

Incidence and Outcome of Infants With Cancer in Canada: A Report From Cancer in Young People in Canada Database

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Infants with cancer are rare and face unique challenges. Our study aims to describe the incidence of infantile cancers in Canada and to compare treatment‐related mortality (TRM) and their outcomes with those of older children. Methods We conducted a retrospective cohort study using the Cancer in Young People in Canada database ...
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Sylvia Cheng, Lesleigh Abbott, Tony Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Donna L. Johnston, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +22 more
wiley   +1 more source

The Effectiveness of Intravenous Admixture Training in a Private Hospital in Surabaya [PDF]

, 2012
In this hospital, the nurses face intravenous (iv) admixture problems in preparing and delivering iv injection and/or infusion to patients due to their limited background knowledge of drug stability and incompatibility.
Herawati, Fauna
core  

Stability of Diluted Adenosine Solutions in Polyolefin Infusion Bags [PDF]

, 2013
Background Intravenous or intracoronary adenosine is used in the cardiac catherization lab to achieve maximal coronary blood flow and determine fractional flow reserve.
Almagambetova, Elise, Blais, Danielle M., Hutchinson, David, Zhao, Fang   +3 more
core   +2 more sources