Results 101 to 110 of about 3,780,548 (370)
Scientific Reports, 2023 Despite recent relevant therapeutic progresses, chronic lymphocytic leukemia (CLL) remains an incurable disease. Selinexor, an oral inhibitor of the nuclear export protein XPO1, is active as single agent in different hematologic malignancies, including ...
Candida Vitale +13 more
doaj +1 more source
Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants [PDF]
, 2022 Denisa Bojková +7 more
openalex +3 more sources
The role of the Bmi1-GSK3β pathway in glioblastoma [PDF]
, 2010 Malignant gliomas remain one of the deadliest of all cancers despite maximal therapy. They present unique challenges to therapy with a median survival of 12 months.
Korur, Serdar
core +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
A chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells
Molecular Systems Biology, 2015 Small molecules often affect multiple targets, elicit off‐target effects, and induce genotype‐specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effects across a broad spectrum of phenotypes can identify ...
Marco Breinig +3 more
doaj +1 more source
Development of gradient diffusion strips to identify the potentiating effect of antimicrobial compounds against multidrug-resistant Klebsiella pneumoniae strains [PDF]
Клиническая микробиология и антимикробная химиотерапияObjective. The aim of the study was to develop gradient diffusion strips with substances capable of potentiating the action of antibiotics for the treatment of infections caused by multidrug-resistant strains of K. pneumoniae.
Likhachev I.V. +4 more
doaj +1 more source
Computational analyses of synergism in small molecular network motifs. [PDF]
PLoS Computational Biology, 2014 Cellular functions and responses to stimuli are controlled by complex regulatory networks that comprise a large diversity of molecular components and their interactions.
Yili Zhang +3 more
doaj +1 more source
Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis [PDF]
, 2010 Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing ...
Izumi, Yukitoshi +3 more
core +2 more sources
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Biomolecules, 2020 Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy ...
Diana Duarte, Nuno Vale
doaj +1 more source