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The potential synergistic effect of combining doxorubicin with vorinostat in urothelial carcinoma therapy. [PDF]

Heliyon
Shen CH, Wang SC, Lee KM, Liu HT, Huang SW, Wu JY, Liu YW.   +6 more
europepmc   +1 more source

Survey of probable synergism between melittin and ciprofloxacin, rifampicin, and chloramphenicol against multidrug-resistant Pseudomonas aeruginosa. [PDF]

Front Microbiol
Sedaghati M, Akbari R, Lotfollahi Hagghi L, Yousefi S, Mesbahi T, Delfi M.   +5 more
europepmc   +1 more source

Modulation of Autophagy by Oncosuppressor FAM46C and Its Implications for Cancer Therapy: An Intriguing Perspective. [PDF]

Biomolecules
Manfrini N.
europepmc   +1 more source

Case Report of Aerococcus urinae Tricuspid Valve Endocarditis, New York, USA. [PDF]

Emerg Infect Dis
Siam T, Stephen T, Munsiff S.
europepmc   +1 more source

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Drug synergism as a basis for rational neuroprotection

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022
Optimization of the choice of neuroprotective therapy regimens in patients with CVD, taking into account the synergism of drug interactions, is basic in real clinical practice. Unfortunately, in modern pharmacology there is no unified way to establish the synergistic spectrum of action of drugs, which would allow systematic investigation of the effects
M.V. Putilina, N.V. Teplova
openaire   +3 more sources

Teratogenic Risks of Drug Synergism

Nature, 1964
IT is well known that the effectiveness of teratogens, measured either in incidence or in severity of resulting malformations, is frequently modified, in a plus or minus direction, by unrelated external conditions. The mechanisms by which these modifying agencies operate are largely unknown.
Ellen M. Clark, Walter Landauer
openaire   +4 more sources

Informatics of Drug Synergism in Naturally Occurring Anticancer Agents [PDF]

Recent Patents on Anti-Cancer Drug Discovery, 2011
Cancer is a multi-factorial disease resulting in uncontrolled division of body cells, with difficult and complex suppression. The main treatment strategy for this disease depends on killing of tumor cells that usually exist in the proximity of normal body cells. During the course of treatment, the healthy cells should not be affected by the toxic doses
Ghavami, Ghazaleh, Kazemali, Mohammad R, Sardari, Soroush   +2 more
openaire   +4 more sources

Drug Synergism: Its Detection and Applications

The Journal of Pharmacology and Experimental Therapeutics, 2001
Two drugs that produce overtly similar effects will sometimes produce exaggerated or diminished effects when used concurrently. A quantitative assessment is necessary to distinguish these cases from simply additive action. This distinction is based on the classic pharmacologic definition of additivity that, briefly stated, means that each constituent ...
R. Tallarida
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The interaction index: a measure of drug synergism

Pain, 2002
Two drugs used in combination may produce enhanced or reduced effects. The degree of enhancement or reduction is measured from the interaction index (gamma), a quantity that indicates the changed potency of the combination. The index is therefore a quantitative marker for the drug combination and effect metric used.
R. Tallarida
openaire   +4 more sources