Results 71 to 80 of about 1,512,902 (358)

Cascade-targeted delivery platform enhances antigen cross-presentation and STING activation for durable cellular immunity

Bioactive Materials
Achieving robust and durable cellular immunity remains a key challenge in the development of subunit vaccines, primarily due to inefficient antigen cross-presentation and inadequate immune activation.
Yuan Xue, Shuting Bai, Yating Wang, Jiaxing Feng, Kun Xiong, Xue Tang, Chunting He, Yanhua Xu, Hongling Yu, Tianyi Luo, Qing Lin, Xun Sun, Ling Zhang, Zhirong Zhang, Tao Gong   +14 more
doaj   +1 more source

Rhodium-Catalyzed Ortho-Vinylation of 2-Arylpyridines and Its Application in the Total Synthesis of Palmatine

Pharmaceutical Fronts, 2020
An efficient protocol by Rh-catalyzed direct C–H vinylation of 2-arylpyridines with a commercially available and air-stable potassium vinyl donor has been developed.
Shan Lv, Ruifang Nie, Lingmei Guo, Yang Zheng, Yanzhao Liu, Li Guo, Yong Wu   +6 more
doaj   +1 more source

AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases

Acta Pharmaceutica Sinica B, 2021
We herein describe AncPhore, a versatile tool for drug discovery, which is characterized by pharmacophore feature analysis and anchor pharmacophore (i.e., most important pharmacophore features) steered molecular fitting and virtual screening. Comparative
Qingqing Dai, Yuhang Yan, Xiangli Ning, Gen Li, Junlin Yu, Ji Deng, Lingling Yang, Guo-Bo Li   +7 more
doaj   +1 more source

Design of double-walled carbon nanotubes for biomedical applications [PDF]

, 2012
Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for
Coley, Helen M., Costa, Sara, Flahaut, Emmanuel, Heister, Elena, McFadden, Johnjoe, Neves, Vera, Silva, S. Ravi P., Soula, Brigitte, Tîlmaciu, Carmen   +8 more
core   +2 more sources

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]

, 2020
Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan, Hong, Jun-Hee, Hu, Sung, Kang, Byoung Heon, Kim, So Yeon, Lee, Ji-Eun, Nam, Dougu, Park, Hye-Kyung, Park, Jong Bae, Yoon, Nam Gu, Yoon, Sora   +10 more
core   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Developmental Disorders in Children Recently Diagnosed With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag, Long Vu, Ritika Miryala, Jeffrey M. Albert, Molly McVoy, Siran M. Koroukian   +5 more
wiley   +1 more source

Application of 7-azaisatins in enantioselective Morita–Baylis–Hillman reaction

Beilstein Journal of Organic Chemistry, 2016
7-Azaisatin and 7-azaoxindole skeletons are valuable building blocks in diverse biologically active substances. Here 7-azaisatins turned out to be more efficient electrophiles than the analogous isatins in the enantioselective Morita–Baylis–Hillman (MBH)
Qing He, Gu Zhan, Wei Du, Ying-Chun Chen
doaj   +1 more source

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting [PDF]

, 2000
PURPOSE: To prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting. METHODS: A glucose-palmitoyl glycol chitosan (PGC) conjugate was synthesised and glucose-PGC polymeric vesicles prepared by sonication of ...
Couet, W., Dufès, Christine, Gray, A.I., Olivier, J.C., Schätzlein, A.G., Tetley, L., Uchegbu, I.F., Watson, D.G.   +7 more
core   +1 more source