Results 1 to 10 of about 1,680,438 (318)

Roles of Lipolytic enzymes in Mycobacterium tuberculosis pathogenesis

Frontiers in Microbiology
Mycobacterium tuberculosis (Mtb) is a bacterial pathogen that can endure for long periods in an infected patient, without causing disease. There are a number of virulence factors that increase its ability to invade the host.
Hong Lin, Jiayin Xing, Hui Wang, Shuxian Wang, Ren Fang, Xiaotian Li, Zhaoli Li, Ningning Song   +7 more
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Drug therapy for double-hit lymphoma

Drugs in Context, 2019
Double-hit lymphoma (DHL) is a rare type of aggressive B-cell lymphoma defined as a high-grade B-cell lymphoma (HGBCL) with the presence of MYC, BCL2 and/or BCL6 rearrangements.
Vania Phuoc , Jose Sandoval-Sus, Julio C Chavez   +2 more
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Health-related quality of life measured with K-BILD is associated with survival in patients with idiopathic pulmonary fibrosis

BMC Pulmonary Medicine
Background Health-related quality of life (HRQoL) assessments and estimates of prognosis are needed for comprehensive care and planning of subsequent treatment in patients with idiopathic pulmonary fibrosis (IPF).
Tuuli Rautajoki, Heidi A. Rantala, Eva Sutinen, Tiina Saarto, Kaisa Rajala, Ida Pesonen, Maria Hollmen, Marjukka Myllärniemi, Juho T. Lehto   +8 more
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Extracellular Vesicles as Tools for Crossing the Blood–Brain Barrier to Treat Lysosomal Storage Diseases

Life
Extracellular vesicles (EVs) are nanosized, membrane-bound structures that have emerged as promising tools for drug delivery, especially in the treatment of lysosomal storage disorders (LSDs) with central nervous system (CNS) involvement.
Giovanni Lerussi, Verónica Villagrasa-Araya, Marc Moltó-Abad, Mireia del Toro, Guillem Pintos-Morell, Joaquin Seras-Franzoso, Ibane Abasolo   +6 more
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Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

Molecules, 2020
Alzheimer’s disease (AD) and Parkinson’s disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide.
Janett Köppen, Anja Schulze, Lisa Machner, Michael Wermann, Rico Eichentopf, Max Guthardt, Angelika Hähnel, Jessica Klehm, Marie-Christin Kriegeskorte, Maike Hartlage-Rübsamen, Markus Morawski, Stephan von Hörsten, Hans-Ulrich Demuth, Steffen Roßner, Stephan Schilling   +14 more
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Development, validation and economic evaluation of a machine learning algorithm for predicting the probability of kidney damage in patients with hyperuricaemia: protocol for a retrospective study

BMJ Open
Introduction Accurate identification of the risk factors is essential for the effective prevention of hyperuricaemia (HUA)-related kidney damage. Previous studies have established the efficacy of machine learning (ML) methodologies in predicting kidney ...
Yong Yang, Bo Deng, Hao Shen, Xinyu Liu, Huan Chang, Zhengyao Hou, Guangjie Gao, Mengting Li, Linke Zou, Jinqi Li, Xingwei Wu   +10 more
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Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation

Scientific Reports, 2020
In clinical trials with early Alzheimer’s patients, administration of anti-amyloid antibodies reduced amyloid deposits, suggesting that immunotherapies may be promising disease-modifying interventions against Alzheimer’s disease (AD).
Thore Hettmann, Stephen D. Gillies, Martin Kleinschmidt, Anke Piechotta, Koki Makioka, Cynthia A. Lemere, Stephan Schilling, Jens-Ulrich Rahfeld, Inge Lues   +8 more
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BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription

Nature Communications
The persistence of HIV-1 in a latent state within long-lived immune cells remains a major barrier to a cure for HIV-1 infection. The “block-and-lock” strategy aims to silence the HIV-1 provirus permanently using latency promoting agents (LPAs).
Eline Pellaers, Julie Janssens, Lore Wils, Alexe Denis, Anayat Bhat, Siska Van Belle, Da Feng, Frauke Christ, Peng Zhan, Zeger Debyser   +9 more
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Combination Drug Therapy for Benign Prostatic Hyperplasia (BPH)

The Annals of African Surgery, 2010
Background: The incidence of benign prostatic hyperplasia peaks 80% in old age. Bothersome symptoms and progression to acute urinary retention and need for surgery are important concerns.
Oliech J.S.
doaj  

Characterization and efficacy against carbapenem-resistant Acinetobacter baumannii of a novel Friunavirus phage from sewage

Frontiers in Cellular and Infection Microbiology
Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a new threat in recent years, owing to its rapidly increasing resistance to antibiotics and new effective therapies are needed to combat this pathogen.
Zhitao Wang, Xue Yang, Hui Wang, Shuxian Wang, Ren Fang, Xiaotian Li, Jiayin Xing, Qianqian Wu, Zhaoli Li, Ningning Song   +9 more
doaj   +1 more source