Results 1 to 10 of about 51,266 (223)
Drug therapies in dermatology [PDF]
Clinical Medicine, 2014 This article explores the current and emerging therapies for skin disease, with a particular focus on chronic plaque psoriasis and metastatic malignant melanoma. We discuss the current biological therapies used for psoriasis and those on the horizon, including small molecules and biosimilars.
Aslam, Arif, Griffiths, Christopher E M
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Drug-therapy networks and the predictions of novel drug targets [PDF]
Journal of Biology 2008, 7:20, 2008 Recently, a number of drug-therapy, disease, drug, and drug-target networks have been introduced. Here we suggest novel methods for network-based prediction of novel drug targets and for improvement of drug efficiency by analysing the effects of drugs on the robustness of cellular networks.
arxiv +1 more source
Medicine, 2012 It is important to monitor drug therapy because the effects of a particular drug regimen can vary significantly between individuals. Wherever possible, therapeutic effect should be monitored using a clinical endpoint (i.e. a measure that directly reflects how the patient feels, functions or survives).
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Mathematical Model of the Impact of Chemotherapy and Anti-Angiogenic Therapy on Drug Resistance in Glioma Growth [PDF]
arXiv, 2023 This research presents a mathematical model of glioma growth dynamics with drug resistance, capturing interactions among five cell populations: glial cells, sensitive glioma cells, resistant glioma cells, endothelial cells, and neuron cells, along with two therapy agent populations: chemotherapy and anti-angiogenic therapy.
arxiv
End-to-End $n$-ary Relation Extraction for Combination Drug Therapies [PDF]
arXiv, 2023 Combination drug therapies are treatment regimens that involve two or more drugs, administered more commonly for patients with cancer, HIV, malaria, or tuberculosis. Currently there are over 350K articles in PubMed that use the "combination drug therapy" MeSH heading with at least 10K articles published per year over the past two decades.
arxiv
European Journal of Clinical Pharmacology, 2011 Cancer chemotherapy was introduced at the same time as antibacterial chemotherapy but has not been nearly such a success. However, there is a growing optimism in oncology today due to the introduction of several more or less target-specific drugs as complements to the conventional cytotoxic drugs introduced half a century ago.
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Optimal personalized therapies in colon-cancer induced immune response using a Fokker-Planck framework [PDF]
arXiv, 2022 In this paper, a new stochastic framework to determine optimal combination therapies in colon cancer-induced immune response is presented. The dynamics of colon cancer is described through an It\"o stochastic process, whose probability density function evolution is governed by the Fokker-Planck equation.
arxiv
The Impact of Competition Between Cancer Cells and Healthy Cells on Optimal Drug Delivery [PDF]
, 2018 Cell competition is recognized to be instrumental to the dynamics and structure of the tumor-host interface in invasive cancers. In mild competition scenarios, the healthy tissue and cancer cells can coexist. When the competition is aggressive, competitive cells, the so called super-competitors, expand by killing other cells.
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DCcov: Repositioning of Drugs and Drug Combinations for SARS-CoV-2 Infected Lung through Constraint-Based Modelling [PDF]
, 2021 The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no effective antiviral drug except treatments for symptomatic therapy. Flux balance analysis is an efficient method to analyze metabolic networks. It allows optimizing for a metabolic function and thus e.g., predicting the growth rate of a specific cell or the production
arxiv +1 more source