Results 11 to 20 of about 1,721,925 (269)
Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background.
Kathrin Tan +5 more
doaj +1 more source
Recent advances in triple negative breast cancer: the immunotherapy era
BMC Medicine, 2019 Background Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer ...
Antonio Marra +2 more
doaj +1 more source
Drug therapy in headache [PDF]
Clinical Medicine, 2015 All physicians will encounter patients with headaches. Primary headache disorders are common, and often disabling. This paper reviews the principles of drug therapy in headache in adults, focusing on the three commonest disorders presenting in both primary and secondary care: tension-type headache, migraine and cluster headache.
openaire +2 more sources
Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats
Frontiers in Behavioral Neuroscience, 2021 Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and vascular injury in the brain. Puerarin (Pur) represents the major isoflavone glycoside of Radix Puerariae, with verified neuroprotective ...
Tiantian Zhu +32 more
doaj +1 more source
Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections
Frontiers in Microbiology, 2023 Antimicrobial resistance is an increasing threat to human populations. The emergence of multidrug-resistant “superbugs” in mycobacterial infections has further complicated the processes of curing patients, thereby resulting in high morbidity and ...
Xudong Ouyang +14 more
doaj +1 more source
Comparative analysis of CDR3 length-dependent patterns in VHHs
Frontiers in ImmunologyIntroductionVHHs, or nanobodies, are distinguished by their compact size, high stability, and unique ability to selectively target specific epitopes. The CDR3 region in VHHs, which plays a crucial role in antigen binding, exhibits significant diversity ...
Lu Zhang +7 more
doaj +1 more source
BMJ OpenObjective Nintedanib is approved for the treatment of interstitial lung disease (ILD) with progressive pulmonary fibrosis (PPF). Real-life data on nintedanib treatment for this indication and on the combined use of antifibrotic and immunomodulatory drugs
Mari Ainola +5 more
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Enhancing TB Vaccine Efficacy: Current Progress on Vaccines, Adjuvants and Immunization Strategies
Vaccines, 2023 Tuberculosis (TB) remains a global infectious disease primarily transmitted via respiratory tract infection. Presently, vaccination stands as the primary method for TB prevention, predominantly reliant on the Bacillus Calmette–Guérin (BCG) vaccine ...
Hui Wang +6 more
doaj +1 more source
Communications BiologyObesity-induced changes in adipose vasculature are well documented, but systematic analyses in other tissues have not been as extensive. Here, we analyze the vessel-covered area and endothelial cell (EC) numbers in seven non-adipose organs (liver, heart,
Emmi Pakarinen +5 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source