Results 11 to 20 of about 5,615,789 (315)
Scientific Reports, 2021 Proliferative diabetic retinopathy (PDR) is a sight-threatening diabetic complication in urgent need of new therapies. In this study we identify potential molecular mechanisms and target candidates in the pathogenesis of PDR fibrovascular tissue ...
Ani Korhonen +3 more
doaj +1 more source
Research and Clinical Landscape of Bispecific Antibodies for the Treatment of Solid Malignancies
Pharmaceuticals, 2021 Solid tumors adopt multiple mechanisms to grow, evade immune responses, and to withstand therapeutic approaches. A major breakthrough in the armamentarium of anti-cancer agents has been the introduction of monoclonal antibodies (mAbs), able to inhibit ...
Gabriele Antonarelli +5 more
doaj +1 more source
Whole-mount immunofluorescence staining of blood and lymphatic vessels in murine small intestine
STAR Protocols, 2023 Summary: The small intestine is an excellent model for studying changes in vasculature in response to different diseases or gene deletions. Here, we present a protocol for whole-mount immunofluorescence staining of blood and lymphatic vessels in the ...
Satu Paavonsalo +3 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2020 Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far.
Kathrin Gnoth +16 more
doaj +1 more source
Antibody–drug conjugates in solid tumors: a look into novel targets
Journal of Hematology & Oncology, 2021 Antibody–drug conjugates (ADCs) are a relatively new class of anticancer agents designed to merge the selectivity of monoclonal antibodies with cell killing properties of chemotherapy.
Carmen Criscitiello +2 more
doaj +1 more source
Biomolecules, 2022 Passive immunotherapy is a very promising approach for the treatment of Alzheimer’s disease (AD). Among the different antibodies under development, those targeting post-translationally modified Aβ peptides might combine efficient reduction in beta ...
Kathrin Gnoth +10 more
doaj +1 more source
International Journal of Molecular Sciences, 2023 The treatment of type 2 diabetes (T2D) necessitates a multifaceted approach that combines behavioral and pharmacological interventions to mitigate complications and sustain a high quality of life. Treatment encompasses the management of glucose levels, weight, cardiovascular risk factors, comorbidities, and associated complications through medication ...
Roni Weinberg Sibony +3 more
openaire +2 more sources
Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis
, 2023 The innovative development of nanomedicine has promised effective treatment options compared to the standard therapeutics for cancer therapy. However, the efficiency of EPR-targeted nanodrugs is not always pleasing as it is strongly prejudiced by the ...
Farzana Parveen +4 more
core +1 more source
Self-Initiation of Antiretroviral Therapy in the Developing World: the Involvement of Private Pharmacies in an HIV Program. [PDF]
, 2012 Self-initiation to antiretroviral treatment (ART) exposes the patient to the risk of drug toxicity, poor adherence to treatment, and escalates the development of drug resistance.
Buma, Deus +8 more
core +1 more source
Alzheimer’s Research & Therapy, 2023 Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain.
Susan Barendrecht +20 more
doaj +1 more source