Results 21 to 30 of about 5,615,789 (315)

Personalizing HIV therapy, mission impossible? [PDF]

, 2013
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source

Drug Therapy [PDF]

Hepatology, 2010
No abstract.
openaire   +3 more sources

Perillaldehyde improves cognitive function in vivo and in vitro by inhibiting neuronal damage via blocking TRPM2/NMDAR pathway

Chinese Medicine, 2021
Background Vascular cognitive dysfunction in patients with vascular dementia (VD) is a kind of severe cognitive dysfunction syndrome caused by cerebrovascular diseases.
Yue Qiu, Xian-jun Xue, Geng Liu, Miao-miao Shen, Chun-yan Chao, Jie Zhang, Ya-qi Guo, Qian-qian Niu, Ya-nan Yu, Yu-ting Song, Huan-huan Wang, Shuang-xi Wang, Yu-jing Chen, Lin-hua Jiang, Peng Li, Ya-ling Yin   +15 more
doaj   +1 more source

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background.
Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck   +5 more
doaj   +1 more source

Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]

, 2014
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Goltsov, Alexey, Stylianos Kyriakidis, Hilal Khalil, Simon P. Langdon, Harrison, David James, Langdon, Simon P., Bown, James L., Khalil, Hilal S., Simon Langdon, Tero Soininen, Khalil, Hilal S, Soininen, Tero, Alexey Goltsov, Huizhong Hu, David J. Harrison, Bown, James, David Harrison, Deeni, Yusuf, Harrison, David J, Kyriakidis, Stylianos, Hu, Huizhong, Deeni, Yusuf Y.; id_orcid, Yusuf Deeni, Hilal S. Khalil, Langdon, Simon P, James Bown, Harrison, David J.   +26 more
core   +1 more source

Recent advances in triple negative breast cancer: the immunotherapy era

BMC Medicine, 2019
Background Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer ...
Antonio Marra, Giulia Viale, Giuseppe Curigliano   +2 more
doaj   +1 more source

Drug Therapy Problems And Quality Of Life In Patients With Chronic Kidney Disease [RM262. M289 2008 f rb]. [PDF]

, 2008
Masalah-masalah terapi drug (DTP) merupakan suatu cabaran penting kepada pengamal penjagaan kesihatan, ianya juga mempengaruhi morbiditi, mortaliti dan kualiti kehidupan pesakit (QoL).
Mahmoud, Mansour Adam
core   +1 more source

Drug resistance with monitored adherence [PDF]

, 2013
Drug resistance can be defined as the failure of a drug to exert its expected effect on pharmacological biomarkers and is caused by pharmacogenetic, cellular or clinical factors.
Walter, Philipp Niklaus
core   +1 more source

AtriplaR/anti-TB Combination in TB/HIV Patients. Drug in Focus. [PDF]

, 2011
Co-administration of anti-tuberculosis and antiretroviral therapy is often inevitable in high-burden countries where tuberculosis is the most common opportunistic infection associated with HIV/AIDS. Concurrent use of rifampicin and several antiretroviral
Semvua Hadija H, Kibiki, Gibson S, Hadija H Semvua, Gibson S Kibiki, Semvua, Hadija H, Kibiki Gibson S   +5 more
core   +1 more source

Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats

Frontiers in Behavioral Neuroscience, 2021
Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and vascular injury in the brain. Puerarin (Pur) represents the major isoflavone glycoside of Radix Puerariae, with verified neuroprotective ...
Tiantian Zhu, Tiantian Zhu, Tiantian Zhu, Moli Zhu, Moli Zhu, Moli Zhu, Yue Qiu, Yue Qiu, Yue Qiu, Zeqing Wu, Zeqing Wu, Zeqing Wu, Ning Huang, Ning Huang, Ning Huang, Guangrui Wan, Guangrui Wan, Guangrui Wan, Jian Xu, Jian Xu, Jian Xu, Ping Song, Ping Song, Ping Song, Shuangxi Wang, Shuangxi Wang, Shuangxi Wang, Yaling Yin, Yaling Yin, Yaling Yin, Peng Li, Peng Li, Peng Li   +32 more
doaj   +1 more source