Results 41 to 50 of about 2,964,728 (312)

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A., Bakhshinyan, David, Berger-Becvar, Angelika, de Araujo, Elvin D., Deininger, Michael W., Fishel, Melissa L., Gawel, Justyna M., Geletu, Mulu, Grimard, Michelle L., Gunning, Patrick T., Heaton, William L., Konieczny, Stephen F., Luchman, H. Artee, O'Hare, Thomas, Raouf, Yasir, Shah, Fenil, Shouksmith, Andrew E., Singh, Sheila K., Venugopal, Chitra, Weiss, Samuel   +19 more
core   +3 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Life After Losing an Adult Child to a Drug Overdose: A Kawa Perspective [PDF]

, 2019
Background: Limited research is available to occupational therapy practitioners focusing on parents’ abilities to cope with the loss of an adult child to a drug overdose.
De Brun, Jessica Nicole, Javaherian-Dysinger, Heather, Kugel, Julie D, Weis, Aaron   +3 more
core   +2 more sources

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery [PDF]

, 2014
Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics.
Conway, Barbara R, Kakadia, Pratibha G.
core   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Prefusion-specific antibody-derived peptides trivalently presented on DNA-nanoscaffolds as an innovative strategy against RSV entry

Frontiers in Virology, 2022
Human respiratory syncytial virus (RSV) is the primary cause of acute lower respiratory tract infections in children and the elderly worldwide, for which neither a vaccine nor an effective therapy is approved.
Leila Issmail, Christin Möser, Christian Jäger, Basma Altattan, Daniel Ramsbeck, Martin Kleinschmidt, Mirko Buchholz, David Smith, David Smith, David Smith, Thomas Grunwald   +10 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Aptamer guided nanomedicines enable precision immune engineering

Discover Applied Sciences
Precision targeting of immune responses is crucial for the ongoing development of therapies for cancer, autoimmune, and infectious diseases. Aptamers, which are short, single-stranded oligonucleotides, are emerging as powerful immunomodulators in ...
Nowar Alsarayreh, Yousef Ijjeh, Hadeel AbuSaifan, Baida’a AlQuaissi, Nirmeen Elzogheir, Dana Alqudah, Sara Al-Mahamid, Somaya Ahmad, Hamdi Nsairat, Alaaldin M. Alkilany, Alqassem Abuarqoub, Mohammad IA Ahmad, Walhan Alshaer   +12 more
doaj   +1 more source

Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice

Ecotoxicology and Environmental Safety, 2021
The increased incidence of metabolic syndrome (MetS) has been demonstrated to be closely associated with external environments, such as unhealthy ambient light exposure.
Shiyao Zhang, Mengyi Xu, Ziyue Shen, Changrui Shang, Wenxiang Zhang, Siyu Chen, Chang Liu   +6 more
doaj   +1 more source