Results 51 to 60 of about 1,721,925 (269)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source
The role of transcriptional regulators in metal ion homeostasis of Mycobacterium tuberculosis
Frontiers in Cellular and Infection MicrobiologyMetal ions are essential trace elements for all living organisms and play critical catalytic, structural, and allosteric roles in many enzymes and transcription factors.
Shuxian Wang +6 more
doaj +1 more source
KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D
eLife, 2019 Vascular endothelial growth factor-C (VEGF-C) acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system.
Sawan Kumar Jha +8 more
doaj +1 more source
Diabetes & Vascular Disease Research, 2020 Aims: The objective of this study was to explore the effects of epigallocatechin-3-gallate (EGCG) on type 2 diabetes mellitus (T2DM). Main methods: Male Sprague–Dawley rats were allocated into six groups.
Wenru Li +6 more
doaj +1 more source
DRUG THERAPY IN PYELITIS [PDF]
JAMA: The Journal of the American Medical Association, 1922 The present study is concerned with an attempt to determine the direct mode of action of several of the more commonly used drugs in the treatment of pyelitis. The action of the alkalis, of hexamethylenamin and of phenyl salicylate has been studied. First, it must be said that pyelitis, in most instances, is a self limited disease, which may disappear ...
openaire +2 more sources
Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel +15 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Roles of Lipolytic enzymes in Mycobacterium tuberculosis pathogenesis
Frontiers in MicrobiologyMycobacterium tuberculosis (Mtb) is a bacterial pathogen that can endure for long periods in an infected patient, without causing disease. There are a number of virulence factors that increase its ability to invade the host.
Hong Lin +7 more
doaj +1 more source
The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature
Pediatric Blood &Cancer, EarlyView.ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi +7 more
wiley +1 more source
BMC Pulmonary MedicineBackground Health-related quality of life (HRQoL) assessments and estimates of prognosis are needed for comprehensive care and planning of subsequent treatment in patients with idiopathic pulmonary fibrosis (IPF).
Tuuli Rautajoki +8 more
doaj +1 more source