Results 121 to 130 of about 2,849,098 (354)

Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]

, 2017
In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De, Mascellino, Maria Teresa, Oliva, Alessandra   +2 more
core   +1 more source

Combination therapy in combating cancer

OncoTarget, 2017
Combination therapy, a treatment modality that combines two or more therapeutic agents, is a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy compared to the mono-therapy approach because it targets key pathways in a
R. Mokhtari, Tina S. Homayouni, N. Baluch, Evgeniya Morgatskaya, Sushil Kumar, Bikul Das, H. Yeger   +6 more
semanticscholar   +1 more source

COMBINATION ANTIHYPERTENSION THERAPY: TRIPLE FIXED COMBINATION OF ANTIHYPERTENSIVE DRUGS

Russian Journal of Cardiology, 2017
The article presents modern view on the role of combination antihypertension therapy in treatment of arterial hypertension. The benefits of fixed combinations are shown, rational combinations described for three antihypertensive medications. The results of investigations provided witnessing the increase of efficacy of antihypertension therapy with ...
O. D. Ostroumova, V. V. Vikentiev, T. F. Guseva   +2 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Prescription Patterns of Antiseizure Medication in Adult Patients with Epilepsy in Kazakhstan (2021–2023)

Medical Sciences
Background/Objectives: Epilepsy is a major neurological disorder associated with significant comorbidity and treatment challenges. In low- and middle-income countries, access to newer antiseizure medications (ASMs) remains limited, and prescription ...
Dina Kalinina, Temirgali Aimyshev, Alimzhan Muxunov, Zhassulan Utebekov, Gaziz Kyrgyzbay, Darkhan Kimadiev, Guldana Zhumabaeva, Abduzhappar Gaipov, Antonio Sarria-Santamera   +8 more
doaj   +1 more source

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy [PDF]

, 2015
The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy.
Bahrami, B., Bakhshaei, P., Ghalamfarsa, G., Hojjat-Farsangi, M., Jadidi-Niaragh, F., Mohammadnia-Afrouzi, M., Sadreddini, S., Yazdani, Y., Yousefi, M.   +8 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Resistance to antibody–drug conjugates: A review

Acta Pharmaceutica Sinica B
Antibody–drug conjugates (ADCs) are antitumor drugs composed of monoclonal antibodies and cytotoxic payload covalently coupled by a linker. Currently, 15 ADCs have been clinically approved worldwide.
Sijia Li, Xinyu Zhao, Kai Fu, Shuangli Zhu, Can Pan, Chuan Yang, Fang Wang, Kenneth K.W. To, Liwu Fu   +8 more
doaj   +1 more source

A theoretical study of the response of vascular tumours to different types of chemotherapy [PDF]

, 2008
In this paper we formulate and explore a mathematical model to study continuous infusion of a vascular tumour with isolated and combined blood-borne chemotherapies.
Jasmina Panovska, Helen M. Byrne, Philip K. Maini, Casciari, Sutherland, Muthukkaruppan, Baptist-Trimbos, Cheng, Stoll, Rowinsky, Sherratt, Ward, Gatenby, Sherratt, Anderson, Byrne, Orme, Orme, Breward, Breward, Hahnfield, d’Onfrio, Panovska, Griffiths, De Angelis, Baxter, Sholley, O’Reilly, O’Reilly, West, Ward, Jackson, Arakelyn, Agur, Sinek, Zheng, Fister, Fister, Balding, Edelstein, Stokes, Press, Degregorio, Jackson, Dordel, Jackson, Laderoute, Pettet   +47 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source