Results 101 to 110 of about 6,853,200 (317)

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]

, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Speich Benjamin, Tritten Lucienne, Jennifer Keiser, Speich, B., Keiser Jennifer, Benjamin Speich, Adelfio Roberto, Keiser, J., Adelfio, R., Tritten, L., Silbereisen Angelika, Vargas Mireille, Angelika Silbereisen, Roberto Adelfio, Silbereisen, A., Vargas, M., Lucienne Tritten, Mireille Vargas   +17 more
core   +2 more sources

Fixed combination drug therapy as an opportunity to improve the efficacy and safety of the conventional back pain treatment

, 2021
According to statistics, 70–90% of the population suffer from back pain, however, despite the enormous efforts to find ways of improving the efficacy and safety of therapy for patients with dorsalgia, and the diversity of therapeutic options, numerous ...
Vitaly V. Kovalchuk
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Carbonic anhydrase XII inhibition overcomes P-glycoprotein-mediated drug resistance: a potential new combination therapy in cancer

, 2021
Intrinsic or acquired resistance to chemotherapy is a major hurdle in the treatment of cancer. One of the key mechanisms of resistance is the overexpression of the drug efflux transporter P-glycoprotein (Pgp). Pgp overexpression renders a large number of
Tonissen, Kathryn, Poulsen, Sally-Ann
core  

Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission [PDF]

, 2012
<p>Background: Artemisinin-based combination therapy (ACT) for treating malaria has activity against immature gametocytes. In theory, this property may complement the effect of terminating otherwise lengthy malaria infections and reducing the ...
Huho, B. J., Charlwood, J Derek, Kihonda, Japhet, Adriana Tami, Christian Lengeler, Huho, B.J., Huho Bernadette J, Heather M Ferguson, Smith, T., Tami, A., Lengeler Christian, Killeen, G. F., Abdulla, Salim M. K., Killeen, Gerard F., J Derek Charlwood, Lengeler, Christian, Aniset Kihonda, Smith, T. A., Salim MK Abdulla, Huho, Bernadette J., Kachur, S Patrick, Charlwood J Derek, Japhet Kihonda, Charlwood, J D, Charlwood, D.J., Smith, Thomas A, Thomas A Smith, Ferguson, Heather M, Killeen, G.F., Abdulla, S. M., Abdulla, S.K., Abdulla, Salim MK, Ferguson, H., Killeen Gerard F, Kihonda, A., Kachur, S.P., Huho, Bernadette J, Kihonda, J., Killeen, Gerry, Abdulla Salim MK, Kachur S Patrick, Smith, Thomas A., Killeen, Gerard F, Kihonda Japhet, Tami, Adriana, Kihonda Aniset, Gerard F Killeen, Tami Adriana, S Patrick Kachur, Charlwood, J. Derek, Lengeler, C., Ferguson, Heather M., Kachur, S. Patrick, Kihonda, Anisette, Ferguson Heather M, Abdulla, Salim M, Kihonda, Aniset, Ferguson, H. M., Charlwood, J. D., Kachur, S. P., Tami, Adriana; id_orcid, Smith Thomas A, Bernadette J Huho   +62 more
core   +2 more sources

Resistance to antibody–drug conjugates: A review

Acta Pharmaceutica Sinica B
Antibody–drug conjugates (ADCs) are antitumor drugs composed of monoclonal antibodies and cytotoxic payload covalently coupled by a linker. Currently, 15 ADCs have been clinically approved worldwide.
Sijia Li, Xinyu Zhao, Kai Fu, Shuangli Zhu, Can Pan, Chuan Yang, Fang Wang, Kenneth K.W. To, Liwu Fu   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration [PDF]

, 2005
Background The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate.Methods and ...
Wynhoven, B, Cane, P, Holguin, A, Pedro Cahn, Maria Belen Bouzas, Africa Holguin, Luis F Brigido, Sirivichayakul, S, Anne-Mieke Vandamme, Camacho, R, Efron, B, Koya Ariyoshi, Grossman, Z, Robert W Shafer, Shafer, RW, Bouzas, MB, Brian Wynhoven, Ricardo Camacho, Jonathan N Weber, Harrigan, PR, Ariyoshi, K, Ana Patricia Carvalho, Rosangela Rodrigues, Rudich, H, Candice Pillay, Soares, MA, Katzenstein, DA, Vandamme, AM, Clarke, J, Lynn Morris, Snoeck, J, Soriano, V, Rodrigues, R, Brigido, LF, Wataru Sugiura, Praphan Phanuphak, Kantor, R, Sugiura, W, John Clarke, Jonathan M Schapiro, Rami Kantor, David A Katzenstein, Carvalho, AP, P Richard Harrigan, Patricia Cane, Phanuphak, P, Brad Efron, Pillay, D, Pillay, C, Sunee Sirivichayakul, Joke Snoeck, Cahn, P, Hagit Rudich, Schapiro, JM, Morris, L, Zehava Grossman, Amilcar Tanuri, Tanuri, A, Weber, JN, Vincent Soriano, Deenan Pillay, Marcelo A Soares   +61 more
core   +2 more sources

Drug Therapy Problems And Quality Of Life In Patients With Chronic Kidney Disease [RM262. M289 2008 f rb]. [PDF]

, 2008
Masalah-masalah terapi drug (DTP) merupakan suatu cabaran penting kepada pengamal penjagaan kesihatan, ianya juga mempengaruhi morbiditi, mortaliti dan kualiti kehidupan pesakit (QoL).
Mahmoud, Mansour Adam
core   +1 more source

The rationale for recommending fixed-dose combination tablets for treatment of tuberculosis

Bulletin of the World Health Organization, 2001
There is considerable exigency to take all necessary steps to cure tuberculosis cases and prevent further emergence of drug-resistant tuberculosis. The most important of these steps is to ensure that the treatment, particularly of sputum smear-positive ...
Blomberg Bjørn, Spinaci Sergio, Fourie Bernard, Laing Richard   +3 more
doaj