Results 91 to 100 of about 6,853,200 (317)

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children. [PDF]

, 2013
BACKGROUND: Asthma is characterised by chronic inflammation of the airways and recurrent exacerbations with wheezing, chest tightness and cough. Treatment with inhaled steroids and bronchodilators often results in good control of symptoms, prevention of ...
Mindus, SM, Ferrara, G, Ferrara, G,, Kew, KM, Karner, C   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Clinical impact of double protease inhibitor boosting with Lopinavir/Ritonavir and Amprenavir as part of salvage antiretroviral therapy [PDF]

, 2003
Purpose: Double protease inhibitor (PI) boosting is being explored as a new strategy in salvage antiretroviral (ARV) therapy. However, if a negative drug interaction leads to decreased drug levels of either or both PIs, double PI boosting could lead to ...
Gough, K., Walmsley, S., Raboud, J., Tseng, A., Phillips, E., Rubin, G., Thompson, C., Abdurrahman, Z., Loutfy, M., Kovacs, C., Rachlis, A.   +10 more
core  

Antimalarial drug resistence and artemisinin based combination therapy : a bio-economic model for elucidating policy choices [PDF]

Antimalarial drug resistance is a major cause of the increasing burden due to P. falciparum malaria. Artemisinin-based combination therapies (ACTs) are now recognised to be the ideal choice for the first-line treatment of ...
Yeung, Shunmay
core   +1 more source

Combining in vivo and in vitro studies to elucidate the inhibitory effect of resveratrol on vorolanib metabolism

Frontiers in Pharmacology
IntroductionVorolanib is a new-generation multi-targeted kinase inhibitor (MTKI) whose drug-drug interaction (DDI) profile remains largely unexplored.
Dongxin Chen, Hailun Xia, Lu Cao, Haoxin Fu, Yan Chen, Shiqi Jiang, Runjuan Zhan, Runjuan Zhan   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria. [PDF]

, 2008
BACKGROUND: Adequate malaria diagnosis and treatment remain major difficulties in rural sub-Saharan Africa. These issues deserve renewed attention in the light of first-line treatment with expensive artemisinin-combination therapy (ACT) and changing ...
Bianca Mengerink, Mosha, F., Bousema, Teun, Arnold Ndaro, Shekalaghe Seif, Shekalaghe, Seif, Sauerwein Robert, Sauerwein, R.W., Gosling Roly, Seif Shekalaghe, Shekalaghe, S., Megiroo, Simon, Mwanziva Charles, Ndaro, A., Frank Mosha, Drakeley, Chris, Gosling, R., Mengerink, Bianca, Chris Drakeley, Teun Bousema, Mengerink, B., Robert Sauerwein, Megiroo Simon, Bousema, T., Mosha, Frank, Drakeley Chris, Mwanziva, C., Mengerink Bianca, Mwanziva, Charles, Megiroo, S., Bousema Teun, Ndaro Arnold, Gosling, Roly, Drakeley, C., Charles Mwanziva, Sauerwein, Robert, Mosha Frank, Simon Megiroo, Roly Gosling, Ndaro, Arnold   +39 more
core   +1 more source

Prescription Patterns of Antiseizure Medication in Adult Patients with Epilepsy in Kazakhstan (2021–2023)

Medical Sciences
Background/Objectives: Epilepsy is a major neurological disorder associated with significant comorbidity and treatment challenges. In low- and middle-income countries, access to newer antiseizure medications (ASMs) remains limited, and prescription ...
Dina Kalinina, Temirgali Aimyshev, Alimzhan Muxunov, Zhassulan Utebekov, Gaziz Kyrgyzbay, Darkhan Kimadiev, Guldana Zhumabaeva, Abduzhappar Gaipov, Antonio Sarria-Santamera   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source