Results 81 to 90 of about 6,853,200 (317)

Open-label comparative clinical study of chlorproguanil−dapsone fixed dose combination (Lapdap™) alone or with three different doses of artesunate for uncomplicated plasmodium falciparum malaria [PDF]

, 2008
The objective of this study was to determine the appropriate dose of artesunate for use in a fixed dose combination therapy with chlorproguanil−dapsone (CPG−DDS) for the treatment of uncomplicated falciparum ...
Peter A Winstanley, Nyirenda, Maggie, Kanjala, Maxwell K., Molyneux, Malcolm, Sam Dunyo, Stephan Duparc, Paula L Kirby, Winstanley Peter A., Kirby, Paula L., Blencowe, Hannah, Daniel G Wootton, Woessner, Mary, Thomas Kanyok, Stephen Ward, Opara, Hyginus, Molyneux Malcolm, Winstanley, Peter A, Wootton Daniel G., Maggie Nyirenda, Ward, Stephen, Dunyo, Sam, Giancarlo A Biagini, Kanjala, Maxwell K, Nyirenda Maggie, Kanyok Thomas, Maxwell K Kanjala, Opara Hyginus, Duparc, Stephan, Kanyok, Thomas, Queen Dube-Mbeye, Duparc Stephan, Malcolm Molyneux, Neate, Colin, Biagini, Giancarlo A, Biagini Giancarlo A., Ward Stephen, Kirby Paula L., Wootton, Daniel G., Wootton, Daniel G, Kirby, Paula L, Hannah Blencowe, Mary Woessner, Kanjala Maxwell K., Molyneux, Malcolm E., Biagini, Giancarlo A., Woessner Mary, Dube-Mbeye Queen, Colin Neate, Hyginus Opara, Neate Colin, Blencowe Hannah, Dunyo Sam, Winstanley, Peter, Dube-Mbeye, Queen, Ward, Steve, Biagini, Giancarlo; id_orcid, Winstanley, Peter A.   +56 more
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Epidemiological, clinical and evolutionary aspects of tuberculosis among elderly patients of a university hospital in Belém, Pará

Revista Brasileira de Geriatria e Gerontologia, 2017
Objective: To evaluate the epidemiological, clinical and evolutionary aspects of tuberculosis in elderly patients of a university hospital in Belém, Pará.
Emanuele Cordeiro Chaves, Irna Carla do Rosário Souza Carneiro, Maria Izabel Penha de Oliveira Santos, Nathália de Araújo Sarges, Eula Oliveira Santos das Neves   +4 more
doaj   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Safety of combination therapy of azilsartan medoxomil and amlodipine: a population-based cohort study [PDF]

Epidemiology and Health
OBJECTIVES This study investigated the safety of azilsartan and amlodipine combination therapy versus other angiotensin receptor blockers (ARBs) and amlodipine in patients with hypertension.
Hyesung Lee, Bin Hong, Chris Tzu-Ting Su, Sungho Bea, Han Eol Jeong, Kyungyeon Jung, Michael Chun-Yuan Cheng, Zoe Chi-Jui Chang, Edward Chia-Cheng Lai, Jongyoung Lee   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy [PDF]

, 2009
Background Change of first-line treatment of uncomplicated malaria to artemisinin-combination therapy (ACT) is widespread in Africa. To expand knowledge of safety profiles of ACT, pharmacovigilance activities are included in the implementation process of
Fogg Carole, Kodua Augustina, Asiimwe, Alex, Dodoo, A., Ofori Tenkorang, David Ofori-Adjei, Tenkorang Ofori, Edmund T Nartey, Ofori-Adjei David, Alex Asiimwe, Tenkorang, O., Alexander NO Dodoo, Nartey Edmund T, Nartey, E., Augustina Kodua, Asiimwe Alex, Carole Fogg, Kodua, A., Dodoo Alexander NO, Ofori-Adjei, D., Fogg, Carole   +20 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Emergence of prions selectively resistant to combination drug therapy.

PLoS Pathogens, 2020
Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc.
Cassandra M Burke, Kenneth M K Mark, Judit Kun, Kathryn S Beauchemin, Surachai Supattapone   +4 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients [PDF]

, 2013
Dr. Fred Stephen Sarfo, The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV ...
SARFO, FRED,STEPHEN
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