Results 81 to 90 of about 2,849,098 (354)

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source

Prospects for Combination Antiarrhythmic Drug Therapy in Cardiology: Is It Time for a Polypill?

Russian Open Medical Journal
In this article, we discuss the feasibility of combination antiarrhythmic drug therapy in the form of a polypill. In our opinion, this type of treatment is currently limited by various factors discussed in this article. Large-sample studies are needed to
Anatoly O. Rubanenko, Andrey A. Garanin, Anton R. Kiselev   +2 more
doaj   +1 more source

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice [PDF]

, 2012
The use of conventional cytotoxic agents at metronomic schedules, alone or in combination with targeted agents or immunotherapy, is being explored as a promising anticancer strategy.
Alaniz, Laura Daniela, Aquino, Jorge Benjamin, Atorrasagasti, María Catalina, Bayo Fina, Juan Miguel, Fiore, Esteban Juan, García, Mariana Gabriela, Malvicini, Mariana, Matar, Pablo, Mazzolini Rizzo, Guillermo Daniel, Piccioni, Flavia Valeria   +9 more
core   +1 more source

The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors

Journal of Hematology & Oncology
Antibody-drug conjugates (ADCs) represent an important class of cancer therapies that have revolutionized the treatment paradigm of solid tumors.
Qing Wei, Peijing Li, Teng Yang, Jiayu Zhu, Lu Sun, Ziwen Zhang, Lu Wang, Xuefei Tian, Jiahui Chen, Can Hu, Junli Xue, Letao Ma, T. Shimura, Jianmin Fang, Jieer Ying, Peng Guo, Xiangdong Cheng   +16 more
semanticscholar   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug. [PDF]

, 2016
Osteosarcoma occurs mostly in children and young adults, who are treated with multiple agents in combination with limb-salvage surgery. However, the overall 5-year survival rate for patients with recurrent or metastatic osteosarcoma is 20-30% which has ...
Chishima, Takashi, Dry, Sarah M, Eilber, Fritz C, Elliott, Irmina, Endo, Itaru, Federman, Noah, Hiroshima, Yukihiko, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Yunfeng, Matsuyama, Ryusei, Murakami, Takashi, Nelson, Scott D, Russell, Tara, Singh, Arun, Tanaka, Kuniya, Yanagawa, Jane, Zhang, Yong, Zhao, Ming   +20 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Toxic Epidermal Necrolysis after Pemetrexed and Cisplatin for Non-Small Cell Lung Cancer in a Patient with Sharp Syndrome [PDF]

, 2012
Background: Pemetrexed is an antifolate drug approved for maintenance and second-line therapy, and, in combination with cisplatin, for first-line treatment of advanced nonsquamous non-small cell lung cancer.
Aguiar D, Azukizawa H, Barlési F, Bastuji-Garin S, Belani CP, Bosch-Barrera J, Bracke A, Cohen MH, Cornelia Then, Daniel Müller, Del Pozzo-Magana BR, Fuld AD, Grader-Beck T, Harr T, Iung, Jobst C. von Einem, Kardaun SH, Lopes G, Martin Reincke, Michael J. Flaig, Mockenhaupt M, Rudolf M. Huber, Schneck J, Seiwert TY, Shih C, Tan SK, Tummino C, Vitiello M, Yun SJ   +28 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source