Results 141 to 150 of about 1,468,006 (309)

Prevalence of Drug-Resistant HIV-1 Variants in Untreated Individuals in Europe: Implications for Clinical Management [PDF]

, 2017
BackgroundInfection with drug-resistant human immunodeficiency virus type 1 (HIV-1) can impair the response to combination therapy. Widespread transmission of drug-resistant variants has the disturbing potential of limiting future therapy options and ...
Angarano, Gioacchino, Balotta, Claudia, Boeri, Enzo, Boucher, Charles A., Camacho, Ricardo, Chaix, Maire-Laure, Costagliola, Dominique, De Luca, Andrea, de Mendoza, Carmen, Derdelinckx, Inge, Grossman, Zehava, Hamouda, Osamah, Hatzakis, Angelos, Hemmer, Robert, Hoepelman, Andy, Horban, Andrzej, Korn, Klaus, Kücherer, Claudia, Leitner, Thomas, Loveday, Clive, MacRae, Eilidh, Maljkovic, Irina, Meyer, Laurence, Nielsen, Claus, Op de Coul, Eline L., Ormaasen, Vidar, Paraskevis, Dimitris, Perrin, Luc, Puchhammer-Stöckl, Elisabeth, Ruiz, Lidia, Salminen, Mika, Schmit, Jean-Claude, Schneider, Francois, Schuurman, Rob, Soriano, Vincent, Stanczak, Grzegorz, Stanojevic, Maja, van de Vijver, David A., Van Laethem, Kristel, Vandamme, Anne-Mieke, Violin, Michela, Wensing, Annemarie M. J., Wilbe, Karin, Yerly, Sabine, Zazzi, Maurizio, Åsjö, Birgitta   +45 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Prescription Pattern and Potential Drug-Drug Interactions of Antihypertensive Drugs in a General Hospital, South Ethiopia

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2015
Purpose: Selection and use of anti-hypertensive agents are not usually compliant with international guidelines. A prescription based survey is the most effective method to assess and evaluate the prescribing pattern of physicians and dispensing practice ...
Fanta Gashe Fufa, Dereje Mirkano, Ramenjiredi Tipathi   +2 more
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Combination Drug Therapy [PDF]

, 2020
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil

Cadernos de Saúde Pública
We investigated the impact of multidrug therapy (MDT) on the epidemiological pattern of leprosy in Juiz de Fora, Brazil, from 1978 to 1995. Evaluation of 1,283 medical charts was performed according to the treatment regimen used in two different periods.
Luzivander S. Soares, Rodrigo de O. Moreira, Vanessa V. Vilela, Márcio J. M. Alves, Ana Flávia M. Pimentel, Ana Paula Ferreira, Henrique C. Teixeira   +6 more
doaj  

Optimizing drug combination and mechanism analysis based on risk pathway crosstalk in pan cancer

Scientific Data
Combination therapy can greatly improve the efficacy of cancer treatment, so identifying the most effective drug combination and interaction can accelerate the development of combination therapy.
Congxue Hu, Wanqi Mi, Feng Li, Lun Zhu, Qi Ou, Maohao Li, Tengyue Li, Yuheng Ma, Yunpeng Zhang, Yingqi Xu   +9 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source