Results 11 to 20 of about 1,337,415 (292)
Understanding and targeting resistance mechanisms in cancer
MedComm, 2023 Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can
Zi‐Ning Lei +6 more
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Nanoparticles for Combination Drug Therapy [PDF]
ACS Nano, 2013 Nanoparticles have recently emerged as a promising class of carriers for the co-delivery of multiple drugs. Combination therapies of small-molecule drugs are common in clinical practice, and it is anticipated that packaging into single macromolecular carriers will enable drug release in precisely balanced ratios and rates and in selectively targeted ...
Liang Ma, Andrew M. Smith, Manish Kohli
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Tools to develop antibiotic combinations that target drug tolerance in Mycobacterium tuberculosis
Frontiers in Cellular and Infection Microbiology, 2023 Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed.
Talia Greenstein +5 more
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Drug Combinations in Breast Cancer Therapy [PDF]
Pharmaceutical Nanotechnology, 2019 Breast cancer therapy involves a multidisciplinary approach comprising surgery, radiotherapy, neoadjuvant and adjuvant therapy. Effective therapy of breast cancer requires maximum therapeutic efficacy, with minimal undesirable effects to ensure a good quality of life for patients.
Funmilola A. Fisusi, Emmanuel O. Akala
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Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]
, 2014 The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Bown, James L. +8 more
core +6 more sources
Open Journal of Psychiatry and Allied Sciences, 2016 Objective: To study the prescribing pattern of antipsychotic drugs in the outpatient department of psychiatry in Silchar Medical College and Hospital (SMCH) of Assam.
Pinaki Chakravarty +2 more
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Recent Advances in Curcumin-Based Combination Nanomedicines for Cancer Therapy
Journal of Functional Biomaterials, 2023 Standard cancer chemotherapeutics often produce significant adverse effects and eventually lose their effectiveness due to the emergence of resistance mechanisms.
Amir R. Afshari +3 more
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Machine learning approaches for drug combination therapies [PDF]
Briefings in Bioinformatics, 2021 AbstractDrug combination therapy is a promising strategy to treat complex diseases such as cancer and infectious diseases. However, current knowledge of drug combination therapies, especially in cancer patients, is limited because of adverse drug effects, toxicity and cell line heterogeneity. Screening new drug combinations requires substantial efforts
Betul Guvenc Paltun +7 more
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BMC Urology, 2021 Background Combination drug therapy for lower urinary tract symptoms (LUTS) is beneficial to selected patients and recommended by guidelines. Patterns of real-world LUTS drug use, especially combination drug therapy, have not been studied extensively ...
Mahmood Ali +6 more
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Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]
, 2015 Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric +14 more
core +2 more sources