Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]
, 2017 An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant ...
Chmielowski, Bartosz +15 more
core +2 more sources
Multi Drug Therapy- Combination of Structural Inhibitors to Eradicate Leprosy
, 2015 : Being persistant infection, caused by Mycobacterium leprae, Leprosy is affecting about 50,000 annually. It affects Schwann cells (the glial cells of peripheral nervous system) and macrophages.
V. Kashyap, A. Pandey, S. Tripathi
semanticscholar +1 more source
Recent Advances in Curcumin-Based Combination Nanomedicines for Cancer Therapy
Journal of Functional Biomaterials, 2023 Standard cancer chemotherapeutics often produce significant adverse effects and eventually lose their effectiveness due to the emergence of resistance mechanisms.
Amir R. Afshari +3 more
doaj +1 more source
Role of gemcitabine in the treatment of advanced and metastatic breast cancer [PDF]
, 2003 Gemcitabine is an antimetabolite drug with proven antitumor activity and tolerability in metastatic breast cancer. In a total of nine studies, gemcitabine monotherapy has reached response rates of up to 37% in the first-line setting, 26% in the second ...
Heinemann, Volker
core +1 more source
Experimental Drugs and Combination Therapy
Immunobiology, 1994 The worldwide increase in tuberculosis, the additional problem of increasing multiple drug resistance (MDR) and the primary resistance of Mycobacterium avium requires new strategies in drug development and in therapy. The reason for development of MDR is manifold. One important factor is the change in cell wall construction which limits the penetration
J K, Seydel +2 more
openaire +2 more sources
Arterial anatomy and arteriographic diagnosis of arteriogenic impotence [PDF]
, 1988 One hundred twenty-six bilateral selective arteriographic examinations of the iliopudendal vascular tree were performed after comprehensive multidisciplinary evaluation in patients with chronic erectile dysfunction.
Bähren, Wolfgang +4 more
core +1 more source
Olmesartan-based monotherapy vs combination therapy in hypertension: A meta-analysis based on age and chronic kidney disease status. [PDF]
, 2017 Antihypertensive monotherapy is often insufficient to control blood pressure (BP). Several recent guidelines advocate for initial combination drug therapy in many patients. This meta-analysis of seven randomized, double-blind studies (N = 5888) evaluated
Bakris, George +3 more
core +1 more source
Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models. [PDF]
, 2017 Metastasis is a major cause of mortality for cancer patients and remains as the greatest challenge in cancer therapy. Driven by multiple factors, metastasis may not be controlled by the inhibition of single target.
DeVere White, Ralph W +11 more
core +1 more source
Combination therapy based on nano codelivery for overcoming cancer drug resistance
, 2020 Multidrug resistance (MDR) has long been a major obstacle in the treatment of malignant tumors. Combination therapy provides a viable and promising strategy to overcome MDR.
Hairui Wang, Yongzhuo Huang
semanticscholar +1 more source
Functionalized MoS2 nanosheet-capped periodic mesoporous organosilicas as a multifunctional platform for synergistic targeted chemo-photothermal therapy [PDF]
, 2018 The combination of different therapies into a single platform has attracted increasing attention as a potential synergistic tumor treatment. Herein, the fabrication of a novel folate targeted system for chemo-photothermal therapy by using thioether ...
Bremner, David H. +7 more
core +2 more sources