Results 11 to 20 of about 2,849,098 (354)
Drug combination therapy for emerging viral diseases
Drug Discovery Today, 2021 Effective therapeutics to combat emerging viral infections are an unmet need. Historically, treatments for chronic viral infections with single drugs have not been successful, as exemplified by human immunodeficiency virus (HIV) and hepatitis C virus ...
Zeenat A. Shyr +3 more
semanticscholar +1 more source
Drug combination and repurposing for cancer therapy: the example of breast cancer
Heliyon, 2021 Cancer is a set of extremely complex diseases, which are increasingly prominent today, as it affects and kills millions of people worldwide, being the subject of intense study both in its pathophysiology and therapy. Especially in women, breast cancer is
A. Correia, F. Gärtner, N. Vale
semanticscholar +1 more source
MedComm – Biomaterials and Applications, 2023 Various nanocarriers have been explored to deliver drugs for combination therapy. However, most nanocarriers are composed of inert materials without contribution for improving the cancer therapeutic effect.
Jingqi Xin +3 more
doaj +1 more source
Advancement of science, 2021 Nanomedicines with photodynamic therapy and reactive oxygen species (ROS)‐triggered drug release capabilities are promising for cancer therapy. However, most of the nanomedicines based on ROS‐responsive nanocarriers still suffer from serious ROS ...
Sheng Wang +8 more
semanticscholar +1 more source
Combination Drug Therapy for the Management of Alzheimer’s Disease
International Journal of Molecular Sciences, 2020 Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Even though the number of AD patients is rapidly growing, there is no effective treatment for this neurodegenerative disorder.
M. Kabir +9 more
semanticscholar +1 more source
Drug Delivery, 2022 Conventional chemotherapy lacking target selectivity often leads to severe side effects, limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both selective drug release and efficient intracellular uptake at the target ...
Rajiv Bajracharya +11 more
semanticscholar +1 more source
Understanding and targeting resistance mechanisms in cancer
MedComm, 2023 Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can
Zi‐Ning Lei +6 more
doaj +1 more source
Tools to develop antibiotic combinations that target drug tolerance in Mycobacterium tuberculosis
Frontiers in Cellular and Infection Microbiology, 2023 Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed.
Talia Greenstein +5 more
doaj +1 more source
Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study [PDF]
Diabetes & Metabolism Journal, 2020 BackgroundThere is limited information regarding the optimal third-line therapy for managing type 2 diabetes mellitus (T2DM) that is inadequately controlled using dual combination therapy.
Jeong Mi Kim +12 more
doaj +1 more source
Metabolic Derangements with Anticonvulsants in Children with Generalised Tonic-clonic Epilepsy: A Cross-sectional Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Epilepsy is one of the most prevalent noncommunicable neurologic conditions, accounting for significant disability and mortality. The effects of Antiepileptic Drugs (AEDs) on total cholesterol, triglycerides, High-Density Lipoprotein ...
Jyoti Sharma +3 more
doaj +1 more source