Results 51 to 60 of about 2,849,098 (354)

Comparison of Single vs Combination Drug Therapy in Extensively Drug Resistant Salmonella typhi: An Observational Study from Pakistan

Infection and Drug Resistance, 2022
Sadia Ishaque,1,2 Beenish Syed,1,3 Sunil Kumar Dodani,4 Sana Anwar5 1Department of Medicine, Liaquat National Hospital, Karachi, Pakistan; 2Department of Infectious Disease Shaheed Mohtarma, Benazir Bhutto Institute of Trauma, Dow University of Health ...
Ishaque S, Syed B, Dodani SK, Anwar S
doaj  

Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis. [PDF]

, 2018
BACKGROUND: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently
Berman, J, Bicanic, T, Fisher, MC, Harrison, TS, Hope, W, Kivuyo, S, Kwon-Chung, J, Mfinanga, S, Molloy, SF, Needleman, L, Rhodes, J, Rugemalila, J, Segal, ES, Stone, NR   +13 more
core   +6 more sources

Combination Cancer Therapy and Reference Models for Assessing Drug Synergy in Glioblastoma

Current Oncology
Glioblastoma is currently an incurable disease despite the development of a wide variety of therapeutic approaches, from surgical methods to immunotherapy.
Semyon A. Sinyavskiy, Nelly S. Chmelyuk, Daria Yu. Travnikova, Vsevolod V. Belousov, Tatiana O. Abakumova   +4 more
doaj   +1 more source

Evaluation of the efficacy of Q-switched ruby laser combined with tranexamic acid for melasma and its effects on melanin metabolism

Pifu-xingbing zhenliaoxue zazhi, 2022
Objective To observe the efficacy of Q switch ruby laser combined with tranexamic acid for melasma and its effects on melanin metabolism. Methods A total of 60 patients with melasma were divided into three groups: Drug group (oral tranexamic acid 500 mg ...
Hua LI, Yiyu ZHAO, Yating HU, Yong HAO, Hui HAN   +4 more
doaj   +1 more source

Optimized Treatment Schedules for Chronic Myeloid Leukemia

, 2016
Over the past decade, several targeted therapies (e.g. imatinib, dasatinib, nilotinib) have been developed to treat Chronic Myeloid Leukemia (CML). Despite an initial response to therapy, drug resistance remains a problem for some CML patients.
Dingli, David, Foo, Jasmine, He, Qie, Leder, Kevin, Zhu, Junfeng   +4 more
core   +3 more sources

The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib

BMC Cancer, 2020
Background Chronic myeloid leukaemia is in principle a treatable malignancy but drug resistance is lowering survival. Recent drug discoveries have opened up new options for drug combinations, which is a concept used in other areas for preventing drug ...
H. Jonathan G. Lindström, Ran Friedman
doaj   +1 more source

Providing antiretroviral care in conflict settings. [PDF]

, 2009
There has been an historic expectation that delivering combination antiretroviral therapy (cART) to populations affected by violent conflict is untenable due to population movement and separation of drug supplies. There is now emerging evidence that cART
Eyawo, Oghenowede, Ford, Nathan, Mills, Edward J, Singh, Sonal   +3 more
core   +2 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Initial Pharmacological Strategies in People with Early Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-Analysis [PDF]

Diabetes & Metabolism Journal
Background Type 2 diabetes mellitus (T2DM) requires stringent glycemic control from an early stage to prevent complications. The most effective treatment regimen for early T2DM remains unclear.
Jong Han Choi, Bo Kyung Koo, Ye Seul Yang, Se Hee Min, Jong Suk Park, Sang Youl Rhee, Hyun Jung Kim, Min Kyong Moon   +7 more
doaj   +1 more source

Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform [PDF]

, 2018
Stimuli-responsive nanoparticles hold great promise for drug delivery to improve the safety and efficacy of cancer therapy. One of the most investigated stimuli-responsive strategies is to induce drug release by heating with laser, ultrasound, or ...
Agarwal, Pranay, He, Xiaoming, Liang, Yutong, Lu, Xiongbin, Tkaczuk, Katherine H. R., Wang, Hai, Xu, Jiangsheng, Zhao, Gang   +7 more
core   +1 more source