Results 21 to 30 of about 1,680,438 (318)
Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background.
Kathrin Tan +5 more
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Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats
Frontiers in Behavioral Neuroscience, 2021 Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and vascular injury in the brain. Puerarin (Pur) represents the major isoflavone glycoside of Radix Puerariae, with verified neuroprotective ...
Tiantian Zhu +32 more
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Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections
Frontiers in Microbiology, 2023 Antimicrobial resistance is an increasing threat to human populations. The emergence of multidrug-resistant “superbugs” in mycobacterial infections has further complicated the processes of curing patients, thereby resulting in high morbidity and ...
Xudong Ouyang +14 more
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Recent advances in triple negative breast cancer: the immunotherapy era
BMC Medicine, 2019 Background Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer ...
Antonio Marra +2 more
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Antiobesity drug therapy [PDF]
Cleveland Clinic Journal of Medicine, 2021 To the Editor : The article by Mauer et al[1][1] in the August issue is an excellent and comprehensive review of antiobesity pharmacologic therapy. The authors twice mention the positive impact of antiobesity medications in reducing blood pressure.
openaire +2 more sources
Enhancing TB Vaccine Efficacy: Current Progress on Vaccines, Adjuvants and Immunization Strategies
Vaccines, 2023 Tuberculosis (TB) remains a global infectious disease primarily transmitted via respiratory tract infection. Presently, vaccination stands as the primary method for TB prevention, predominantly reliant on the Bacillus Calmette–Guérin (BCG) vaccine ...
Hui Wang +6 more
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The Nanotechnology-Based Approaches against Kirsten Rat Sarcoma-Mutated Cancers
Pharmaceutics, 2023 Kirsten rat sarcoma (KRAS) is a small GTPase which acts as a molecular switch to regulate several cell biological processes including cell survival, proliferation, and differentiation. Alterations in KRAS have been found in 25% of all human cancers, with
Fernanda Andrade +9 more
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Comparative analysis of CDR3 length-dependent patterns in VHHs
Frontiers in ImmunologyIntroductionVHHs, or nanobodies, are distinguished by their compact size, high stability, and unique ability to selectively target specific epitopes. The CDR3 region in VHHs, which plays a crucial role in antigen binding, exhibits significant diversity ...
Lu Zhang +7 more
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BMJ OpenObjective Nintedanib is approved for the treatment of interstitial lung disease (ILD) with progressive pulmonary fibrosis (PPF). Real-life data on nintedanib treatment for this indication and on the combined use of antifibrotic and immunomodulatory drugs
Mari Ainola +5 more
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