Results 41 to 50 of about 133,970 (253)

Consolidation of Organized Crime in the Orinoco Mining Arc (OMA): The Control of Illegal Mining, Human Trafficking, and Other Crimes

Journal of Illicit Economies and Development, 2023
The Orinoco Mining Arc (OMA) is in the south of Venezuela, a region rich in minerals and natural resources with a particular social, economic, and security dynamic.
Sara Mariella Lambertini
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Drug-Trafficking Economy and Its Dynamics in Latin America

Íconos, 2013
This article analyzes the behavior of drug-trafficking economy in Latin America during the last twelve years and its influence in the configuration of a new crime scenario in the region.
Daniel Pontón C.
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Preventing and combating drug trafficking

ACROSS
According to researchers, the dedication of a whole spectrum of customs representatives' activity emphasizes the importance of this type of intermediary services in the Republic of Moldova, but also in the states where international trade in goods is ...
Alexandru PARENIUC, Andrei NASTAS
doaj   +1 more source

Nuevas geografías del narcotráfico. La novela gallega sobre el tráfico de drogas

Confluenze, 2020
The drug trafficking fiction is expanding throughout a new geography. The almost recent appearance of Galician novels about cocaine trafficking in Northern Spain and the connections between the local capos with Colombian and Mexican cartels enriches the ...
Felipe Oliver
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

United Nations Office on Drugs and Crime's Efforts to Prevent the Distribution of Synthetic Drugs in Southeast Asia

Siyar Journal
This study describes UNODC's efforts to prevent the circulation of synthetic drugs in Southeast Asia. This study was conducted to determine what efforts UNODC, as an international organization, has made to address the high number of synthetic drug ...
Muhammad Rizki Dwi Nurdiansyah, Wahidah Zein Br Siregar   +1 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source