Results 41 to 50 of about 345,035 (349)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Consolidation of Organized Crime in the Orinoco Mining Arc (OMA): The Control of Illegal Mining, Human Trafficking, and Other Crimes

open access: yesJournal of Illicit Economies and Development, 2023
The Orinoco Mining Arc (OMA) is in the south of Venezuela, a region rich in minerals and natural resources with a particular social, economic, and security dynamic.
Sara Mariella Lambertini
doaj   +1 more source

Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]

open access: yes, 2020
© The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa   +3 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Disrupting Illicit Supply Networks: New Applications of Operations Research and Data Analytics to End Modern Slavery [PDF]

open access: yes, 2018
Report from a 2017 National Science Foundation workshop on promising research directions for applications of operations research and data analytics toward the disruption of illicit supply networks like human trafficking.
Busch-Armendariz, Noël   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

A Sociological Approach to Drug Use

open access: yesEIRP Proceedings, 2021
Lately, the illicit drug market in Romania has shown a continuous dynamics, registering an increase both in the availability of most types of drugs consumed and in the total amount of drugs confiscated, especially cocaine and cannabis. The availability
Angela-Mihaela Ene
doaj  

Border Security: A Comprehensive Review of the United States’ Approach to Southwest Border Policy [PDF]

open access: yes, 2015
This paper addresses the effect that the presence of a physical border wall on the southern United States-Mexico border has on deterring unauthorized immigration, illegal drug-trafficking, and countering narco-terrorism.
Pacheco, Nicholas M.
core   +2 more sources

Treading the fine white line: cocaine trafficking [PDF]

open access: yes, 2016
The illicit drug’s trade is a highly profitable business that grasps the interest of millions of people and equally affects millions of others. Cocaine is a highly addictive drug that plagues many countries.
McNicholl, S, O'Hagan, A
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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